Prostaglandin A 1

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Structural formula
Structural formula of prostaglandin A1
General
Surname Prostaglandin A 1
other names
  • (13 E , 15 S ) -15-Hydroxy-9-oxoprosta-10,13-dien-1-acid
  • PGA 1
Molecular formula C 20 H 32 O 4
External identifiers / databases
CAS number 14152-28-4
EC number 682-017-9
ECHA InfoCard 100.207.131
PubChem 5281912
Wikidata Q27098093
properties
Molar mass 336.47 g mol −1
safety instructions
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Prostaglandin A 1 is a chemical compound from the group of prostaglandins . Prostaglandin A 1 occurs naturally in animals. It is a metabolite in the arachidonic acid - metabolism . PGA 1 induced by H and N- Ras the MAPK signaling pathway to apoptosis . PGA1 inhibits the replication of the hepatitis C virus .

As a cyclopentone prostaglandin, PGA1 partially forms a Michael adduct with free thiol groups .

Individual evidence

  1. ↑ a b Data sheet Prostaglandin A 1 , United States Pharmacopeia (USP) Reference Standard from Sigma-Aldrich , accessed on October 10, 2016 ( PDF ).
  2. ↑ B. Anta, A. Pérez-Rodríguez, J. Castro, CA García-Domínguez, S. Ibiza, N. Martínez, LM Durá, S. Hernández, T. Gragera, D. Peña-Jiménez, M. Yunta, N Zarich, P. Crespo, JM Serrador, E. Santos, A. Muñoz, JL Oliva, JM Rojas-Cabañeros: PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes. In: Cell death & disease. Volume 7, number 7, July 2016, p. E2311, doi : 10.1038 / cddis.2016.219 , PMID 27468687 , PMC 4973357 (free full text).
  3. ↑ A. Tsukimoto, R. Sugiyama, M. Abe, H. Nishitsuji, Y. Shimizu, K. Shimotohno, G. Kawai, H. Takaku: A new role for PGA1 in inhibiting hepatitis C virus-IRES-mediated translation by targeting viral translation factors. In: Antiviral research. Volume 117, May 2015, pp. 1-9, doi : 10.1016 / j.antiviral.2015.01.013 , PMID 25666760 .
  4. ↑ S. Gharbi, B. Garzón, J. Gayarre, J. Timms, D. Pérez-Sala: Study of protein targets for covalent modification by the antitumoral and anti-inflammatory prostaglandin PGA1: focus on vimentin. In: Journal of mass spectrometry: JMS. Volume 42, Number 11, November 2007, pp. 1474-1484, doi : 10.1002 / jms.1291 , PMID 17960581 .