Phospholipid transfer protein

Phospholipid transfer protein
Properties of human protein
Mass / length primary structure	476 amino acids
Isoforms	2
Identifier
Gene name	PLTP
External IDs	OMIM : 172425 ; UniProt : P55058 ;
Transporter classification
TCDB	1.C.40.1.4
designation	BPI / LBP family
Occurrence
Homology family	BPI / LBP
Parent taxon	Vertebrates

The phospholipid transfer protein (PLTP) is a protein in vertebrate blood that catalyzes the passive diffusion of lipids from LDL and liposomes out into HDL particles . It is a pore-forming protein , it is indispensable in reverse cholesterol transport . In humans, PLTP is expressed in a variety of tissue types and released into the blood plasma. According to the latest studies, PLTP also appears to be an essential component of the disease process of atherosclerosis and is therefore a very promising target for the pharmaceutical industry .

The larger the HDL particle, the lower the PLTP activity. Also, vitamin E is transported particle LDL of PLTP in HDL and. PLTP also appears to be important for preventing endotoxin shock by distributing lipopolysaccharides in the blood onto lipoprotein particles and thus neutralizing them.

Individual evidence

↑ UniProt P55058
↑ TCDB : 1.C.40
↑ Samyn H, Moerland M, van Gent T, et al. : Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study . In: J. Lipid Res . 49, No. 12, December 2008, pp. 2504-12. doi : 10.1194 / jlr.M800080-JLR200 . PMID 18711210 .
↑ Cheung MC, Wolfbauer G, Deguchi H, Fernández JA, Griffin JH, Albers JJ: Human plasma phospholipid transfer protein specific activity is correlated with HDL size: implications for lipoprotein physiology . In: Biochim. Biophys. Acta . 1791, No. 3, March 2009, pp. 206-11. doi : 10.1016 / j.bbalip.2008.12.010 . PMID 19162221 .
↑ Hacquebard M, Vandenbranden M, Malaisse WJ, Ruysschaert JM, Deckelbaum RJ, Carpentier YA: Vitamin E transfer from lipid emulsions to plasma lipoproteins: mediation by multiple mechanisms . In: Lipids . 43, No. 7, July 2008, pp. 663-71. doi : 10.1007 / s11745-008-3184-3 . PMID 18509690 .
↑ Gautier T, Klein A, Deckert V, et al. : Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in mice . In: J. Biol. Chem. . 283, No. 27, July 2008, pp. 18702-10. doi : 10.1074 / jbc.M802802200 . PMID 18458077 .

Web links

D'Eustachio / Jassal / reactome: Spherical HDL binds membrane-associated free cholesterol and phospholipids

[1] UniProt P55058

[2] TCDB : 1.C.40

[3] Samyn H, Moerland M, van Gent T, et al. : Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study . In: J. Lipid Res . 49, No. 12, December 2008, pp. 2504-12. doi : 10.1194 / jlr.M800080-JLR200 . PMID 18711210 .

[4] Cheung MC, Wolfbauer G, Deguchi H, Fernández JA, Griffin JH, Albers JJ: Human plasma phospholipid transfer protein specific activity is correlated with HDL size: implications for lipoprotein physiology . In: Biochim. Biophys. Acta . 1791, No. 3, March 2009, pp. 206-11. doi : 10.1016 / j.bbalip.2008.12.010 . PMID 19162221 .

[5] Hacquebard M, Vandenbranden M, Malaisse WJ, Ruysschaert JM, Deckelbaum RJ, Carpentier YA: Vitamin E transfer from lipid emulsions to plasma lipoproteins: mediation by multiple mechanisms . In: Lipids . 43, No. 7, July 2008, pp. 663-71. doi : 10.1007 / s11745-008-3184-3 . PMID 18509690 .

[6] Gautier T, Klein A, Deckert V, et al. : Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in mice . In: J. Biol. Chem. . 283, No. 27, July 2008, pp. 18702-10. doi : 10.1074 / jbc.M802802200 . PMID 18458077 .