Peter Gottfried Kremsner

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Peter Gottfried Kremsner (born May 16, 1961 in Wiener Neustadt ) is an Austrian infectiologist and tropical medicine specialist .

Career

Kremsner grew up in Sigleß , Austria. He studied medicine at the University of Vienna and received his doctorate in medicine in 1985. He began his academic career as a doctor at the Institute for Specific Prophylaxis and Tropical Medicine at the University of Vienna.

In 1987 he went to Brazil to work for the Superintendencia de Campanhas de Saude Publica in Rio Branco.

From 1988 to 1996 he was group leader at the Institute for Tropical Medicine in Berlin . In 1990 he received his habilitation in tropical medicine and specific prophylaxis at the University of Vienna and in 1992 he completed his habilitation in tropical medicine and parasitology at the Humboldt University in Berlin .

In 1992 he took over the research direction at the Albert Schweitzer Hospital and founded the medical research center in Lambaréné , Gabon , now the Center de Recherches Médicales de Lambaréné (CERMEL), and made it one of the leading research and training centers in Africa.

In 1996 Kremsner was appointed professor for human parasitology at the University of Tübingen . Since 2008 he has been Professor of Tropical Medicine, Travel Medicine and Parasitology at the University of Tübingen and Medical Director of Department VII of the Medical Clinic and the Institute for Tropical Medicine. In 2014 he was appointed CEO of the Comprehensive Infectious Disease Center Tübingen (CIDiC) at the University Hospital Tübingen .

Kremsner is married to the lawyer Inge Thomforde. You have three children. He is a dual Austrian-Gabonese citizen.

research

Kremsner carried out numerous studies on infectious diseases and is the author of 600 scientific publications. Since the 1990s he has been the most cited scientist in the field of parasitology in Germany and malaria in Europe (EU27). He is considered a respected scientist and virus expert who classified and assessed the risk of infection and the course of disease during the Covid 19 pandemic .

Kremsner was the head of studies for key studies on the development of atovaquone / proguanil , artesunate / amodiaquine , artesunate / pyronaridine and parenteral artesunate for malaria therapy and prophylaxis. He and his team also developed a simplified method for assessing the severity of malaria. With this method, the course of the disease can be better predicted and the malaria therapy can be adjusted using the so-called “Lambaréné score”. The “Lambaréné Score” is based on the clinical parameters coma and heavy breathing and does not depend on laboratory tests. This score was developed from data from a study led by Kremsner on 26,000 children with severe malaria. He was also involved in the phase 3 trial of the malaria vaccine, RTS, S / AS01 as a member of the lead study committee and as coordinator of the clinical trials in Lambaréné. Since 2011 he has been working with his team on the development of other malaria vaccines, in particular PfSPZ-based vaccines in cooperation with the company Sanaria Inc. A study of a PfSPZ vaccine carried out by his team in Tübingen showed 100 percent protection, which the WHO guidelines for worldwide use of 75% even surpasses. Kremsner and his teams in Tübingen and Lambaréné also developed a controlled human malaria infection model. Using this model can significantly reduce the time it takes to develop malaria vaccines and drugs clinically.

Awards

  • Karl Hermann Spitzy Prize, 1990
  • Fellow of the Royal College of Physicians, London, 2003
  • Grand Prix of the Gabonese National Center for Scientific and Technical Research (CENAREST), 2010
  • Charles C. Shepard Science Award, 2015
  • Adjunct Professor at the Medical University of Vienna, 2016
  • International Honorary Fellow of the American Society of Tropical Medicine and Hygiene, 2017
  • Memento Prize for Neglected Diseases, 2017
  • Honorary Professor, Hanoi, Vietnam, 2018
  • L'Ordre National du Merite Gabonais au Grade de Chevalier, Gabon, 2018

Selected publications

  • Lell B, Mordmüller B, Dejon Agobe JC, Honkpehedji J, Zinsou J, Mengue JB, Loembe MM, Adegnika AA, Held J, Lalremruata A, Nguyen TT, Esen M, Kc N, Ruben AJ, Chakravarty S, Lee Sim BK, Billingsley PF, James ER, Richie TL, Hoffman SL, Kremsner PG: Impact of Sickle Cell Trait and Naturally Acquired Immunity on Uncomplicated Malaria after Controlled Human Malaria Infection in Adults in Gabon . In: The American Journal of Tropical Medicine and Hygiene . 98, No. 2, February 2018, pp. 508-515. doi : 10.4269 / ajtmh.17-0343 . PMID 29260650 .
  • Mordmüller B, Surat G, Lagler H, Chakravarty S, Ishizuka AS, Lalremruata A, Gmeiner M, Campo JJ, Esen M, Ruben AJ, Held J, Calle CL, Mengue JB, Gebru T, Ibáñez J, Sulyok M, James ER , Billingsley PF, Natasha KC, Manoj A, Murshedkar T, Gunasekera A, Eappen AG, Li T, Stafford RE, Li M, Felgner PL, Seder RA, Richie TL, Sim BK, Hoffman SL, Kremsner PG: Sterile protection against human malaria by chemoattenuated PfSPZ vaccine . In: Nature . 542, No. 7642, February 2017, pp. 445-449. doi : 10.1038 / nature21060 . PMID 28199305 .
  • Kremsner PG, Adegnika AA, Hounkpatin AB, Zinsou JF, Taylor TE, Chimalizeni Y, Liomba A, Kombila M, Bouyou-Akotet MK, Mawili Mboumba DP, Agbenyega T, Ansong D, Sylverken J, Ogutu BR, Otieno GA, Wangwe A , Bojang KA, Okomo U, Sanya-Isijola F, Newton CR, Njuguna P, Kazungu M, Kerb R, Geditz M, Schwab M, Velavan TP, Nguetse C, Köhler C, Issifou S, Bolte S, Engleitner T, Mordmüller B. , Krishna S: Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial . In: PLoS Medicine . 13, No. 1, January 2016, p. E1001938. doi : 10.1371 / journal.pmed.1001938 . PMID 26757276 . PMC 4710539 (free full text).
  • Efficacy and safety of RTS, S / AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomized, controlled trial . In: Lancet (London, England) . 386, No. 9988, July 2015, pp. 31-45. doi : 10.1016 / S0140-6736 (15) 60721-8 . PMID 25913272 . PMC 5626001 (free full text).
  • Mordmüller B, Supan C, Sim KL, Gómez-Pérez GP, Ospina Salazar CL, Held J, Bolte S, Esen M, Tschan S, Joanny F, Lamsfus Calle C, Löhr SJ, Lalremruata A, Gunasekera A, James ER, Billingsley PF, Richman A, Chakravarty S, Legarda A, Muñoz J, Antonijoan RM, Ballester MR, Hoffman SL, Alonso PL, Kremsner PG: Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centers . In: Malaria Journal . March 14, 2015, p. 117. doi : 10.1186 / s12936-015-0628-0 . PMID 25889522 . PMC 4371633 (free full text).
  • Lell B, Luckner D, Ndjavé M, Scott T, Kremsner PG: Randomized placebo-controlled study of atovaquone plus proguanil for malaria prophylaxis in children . In: Lancet (London, England) . 351, No. 9104, March 1998, pp. 709-13. doi : 10.1016 / S0140-6736 (97) 09222-2 . PMID 9504515 .

Individual evidence

  1. ^ Peter Kremsner: Expert in tropical medicine . November 28, 2013.
  2. ↑ cermel.org/board of directors .
  3. ↑ a b Institute for Tropical Medicine (Medical Clinic, Department VII) (PDF; 110.23 kB)
  4. ↑ Schwarzwälder Bote, Oberndorf, Germany: Rosenfeld: Profession leads him all over the world - Zollernalb - Black Forest Bote .
  5. ^ Peter G. Kremsner - Google Scholar Citations .
  6. ↑ Laborjournal: Laborjournal online: Ranking .
  7. ^ SWR1 BW, SWR1 BW: Prof. Peter Kremsner. Retrieved May 12, 2020 .
  8. ↑ Helbok R, Kendjo E, Issifou S, Lackner P, Newton CR, Kombila M, Agbenyega T, Bojang K, Dietz K, Schmutzhard E, Kremsner PG: The Lambaréné Organ Dysfunction Score (LODS) is a simple clinical predictor of fatal malaria in African children . In: The Journal of Infectious Diseases . 200, No. 12, December 2009, pp. 1834-41. doi : 10.1086 / 648409 . PMID 19911989 .
  9. ↑ Efficacy and safety of RTS, S / AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomized, controlled trial . In: Lancet . 386, No. 9988, July 2015, pp. 31-45. doi : 10.1016 / S0140-6736 (15) 60721-8 . PMID 25913272 . PMC 5626001 (free full text).
  10. ↑ Deutsche Welle (www.dw.com): Kremsner: New malaria vaccine is '100 percent protective' - DW - February 16, 2017 .
  11. ↑ New process allows tailor-made malaria research - University of Tübingen .
  12. ↑ Antibiotics Monitor - 4/5/05 - Anniversary Issue Part 1 .
  13. ↑ Gabon: Le professeur Peter Kremsner et le docteur Edgar Brice Ngoungou décrochent les 100,000,000 du Prix CENAREST 2010 - allAfrica.com
  14. ^ DZIF: Professor Peter Kremsner has been nominated as Honorary International Fellow .
  15. ↑ Memento Prize 2017: Award for commitment against neglected diseases .
  16. ^ Vietnamese - German center of medical research launched in Hanoi .
personal data
SURNAME Kremsner, Peter Gottfried
BRIEF DESCRIPTION Austrian infectiologist and tropical medicine specialist
DATE OF BIRTH May 16, 1961
PLACE OF BIRTH Wiener Neustadt