Amodiaquine

Structural formula
General
Non-proprietary name	Amodiaquine
other names	4 - [(7-chloroquinolin-4-yl) amino] -2- (diethylaminomethyl) phenol ( IUPAC ); Amidoquine;
Molecular formula	C 20 H 22 ClN 3 O
External identifiers / databases
EC number	201-669-3
ECHA InfoCard	100.001.518
PubChem	2165
ChemSpider	2080
DrugBank	DB00613
Wikidata	Q239569
Drug information
ATC code	P01 BA06
Drug class	Antiprotozoic
properties
Molar mass	355.86 g · mol -1
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Dihydrochloride dihydrates;	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Amodiaquine is a drug for the treatment of by Plasmodium falciparum induced malaria which chemically and pharmacologically to the chloroquine similar.

Pharmacological properties

Amodiaquine is similar in structure and mode of action to chloroquine and at least as effective, but has a longer plasma half-life than chloroquine. Amodiaquine is also effective against many chloroquine-resistant plasmodia.

Amodiaquine is also available from the FDA preferred substrate for the marker reaction of cytochrome P450 -2C8 in the in vitro - metabolism .

Preparations and Uses

Amodiaquine has been used in monotherapy for a long time, especially in Africa, but lately mainly in fixed combination with other active ingredients such as artesunate ( combination preparation) for the treatment of malaria. The artesunate-amodiaquine combination preparation ASAQ was developed in collaboration between the Drugs for Neglected Diseases Initiative (DNDi) and sanofi-aventis and approved in several African countries. Older amodiaquine monopreparations such as Camoquin have since been withdrawn from the market in various European countries and the USA because of serious side effects. At lower doses, such as those used in combination therapy, severe side effects were less pronounced.

The main focus for the application of artesunate amodiaquine is the treatment of the uncomplicated malaria tropica , especially with plasmodia, which are resistant to other drugs like chloroquine .

Individual evidence

↑ Amodiaquin dihydrochloride dihydrate data sheet from Sigma-Aldrich , accessed on May 15, 2017 ( PDF ).

↑ on the ASAQ registration on DNDi.org ( memento of July 23, 2007 in the Internet Archive ).

^ Abstract to ASAQ ( Memento of September 30, 2007 in the Internet Archive ) by Doctors Without Borders .

[Sigma-1] Amodiaquin dihydrochloride dihydrate data sheet from Sigma-Aldrich , accessed on May 15, 2017 ( PDF ).

[2] the ASAQ registration on DNDi.org ( memento of July 23, 2007 in the Internet Archive ).

[3] Abstract to ASAQ ( Memento of September 30, 2007 in the Internet Archive ) by Doctors Without Borders .