Peter H. Seeburg

from Wikipedia, the free encyclopedia

Peter H. Seeburg (born August 21, 1944 in Querfurt ; † August 22, 2016 ) was a German neurobiologist and biochemist .

Peter Seeburg (1993)

Life

Seeburg studied chemistry and biochemistry. After receiving his doctorate from the University of Tübingen in 1974, he began postdoctoral training three years later at the University of California, San Francisco . His main research interests were the characterization of receptors and ligand-gated ion channels .

In 1978 he became a research associate at Genentech in San Francisco and in 1985 became a senior scientist there. Here he was instrumental in the development of Protropin , the first drug marketed by Genentec. Protropin is somatotropin ( human growth hormone ) produced synthetically in E. coli using genetic engineering methods . There was a legal dispute between UCSF and Genentech about the origin of the DNA used for expression . From 1986 to 1996 he was a professor at the ZMBH at Heidelberg University . The focus was on the functional analysis of glutamate receptors and in particular the importance of RNA editing for their function. Since 1996 he has been Director and Scientific Member in the Department of Molecular Neurobiology at the Max Planck Institute for Medical Research . In particular, with the help of transgenic mice and knockout mice, he made significant contributions to the function of glutamate receptors for learning and memory.

In 1999, Seeburg was warned by Hubert Markl , the president of his employer at the time, the Max Planck Society, for scientific misconduct because the indication of the origin of a DNA sample was incorrectly stated in a publication from 1979. The background to this was a patent dispute between the University of California and the Genentech company over the patent for the genetic engineering of somatropin. Seeburg first worked at the University of California and moved from there to Genentech.

Seeburg had been a member of EMBO since 1989 . In 2007 he was awarded the Belgian International Research Prize InBev-Baillet Latour Health Prize .

honors and awards

Web links

Individual evidence

  1. ^ Obituary notice Peter H. Seeburg (Max Planck Institute for Medical Research Heidelberg) , FAZ , August 2, 2016
  2. ^ Obituary notice Peter H. Seeburg (Max Planck Society) , FAZ , August 2, 2016
  3. ^ Obituary by Peter H. Seeburg (Chica and Heinz Schaller Foundation) , August 29, 2016
  4. ↑ Wisden, W. (2016) A tribute to Peter H Seeburg (1944-2016): a founding father of molecular neurobiology. Front. Mol. Neurosci. 9: 133. doi : 10.3389 / fnmol.2016.00133
  5. ^ Sprengel, R., Freudenberg, F. (2016). A tribute to Peter H. Seeburg (8.21.1944–8.22.2016). Neurobiol Learn Mem 136, A1 – A2
  6. ↑ DV Goeddel, HL Heyneker, T. Hozumi, R. Arentzen, K. Itakura, DG Yansura, MJ Ross, G. Miozzari, R. Crea, PH Seeburg: Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone . In: Nature. Volume 281, Number 5732, October 1979, pp. 544-548, PMID 386136 .
  7. ^ R. Dalton: Charges fly in $ 1bn hormone patent battle. In: Nature. Volume 399, number 6734, May 1999, p. 289, doi : 10.1038 / 20492 , PMID 10360558 .
  8. ^ PH Seeburg: A-to-I editing: new and old sites, functions and speculations. In: Neuron. Volume 35, Number 1, July 2002, pp. 17-20, PMID 12123604 (review).
  9. ↑ DM Bannerman, R. Sprengel, DJ Sanderson, SB McHugh, JN Rawlins, H. Monyer, PH Seeburg: Hippocampal synaptic plasticity, spatial memory and anxiety. In: Nature reviews. Neuroscience. Volume 15, number 3, March 2014, pp. 181-192, doi : 10.1038 / nrn3677 , PMID 24552786 .
  10. ↑ Michael Hagmann: Scientific Misconduct - Researcher Rebuked for 20-Year-Old Misdeed , in: Science, December 17, 1999, Vol 286, page 2249
  11. ↑ Committee accuses genetic researchers of wrongdoing - Max Planck Society criticizes institute director - in: Berliner Zeitung December 15, 1999, accessed November 15, 2016
personal data
SURNAME Seeburg, Peter H.
ALTERNATIVE NAMES Seeburg, Horst-Peter (full name)
BRIEF DESCRIPTION German neurobiologist and biochemist
DATE OF BIRTH August 21, 1944
PLACE OF BIRTH Querfurt
DATE OF DEATH 22nd August 2016