Pickardt Syndrome
| Classification according to ICD-10 | |
|---|---|
| E23 | Underactive and other pituitary disorders Conditions listed regardless of whether the pituitary or hypothalamus disorder is in the pituitary gland. |
| E23.0 | Hypopituitarism - Isolated deficiency of thyrotropin |
| ICD-10 online (WHO version 2019) | |
The pickardt syndrome (also Pickardt-Fahlbusch syndrome) is a tertiary hypothyroidism , that is, an underactive thyroid gland , which by interruption of the portal vasculature between the hypothalamus and pituitary is limited.
Other endocrine dysfunctions that can be associated with Pickardt syndrome are suprasellar deficits such as secondary hypogonadism and functional hyperprolactinemia .
Common causes of Pickardt-Fahlbusch syndrome are bleeding , tumors , heart attacks or a traumatic brain injury .
A congenital variant of Pickardt-Fahlbusch syndrome is called Pituitary stalk interruption syndrome (PSIS) . It is equipped with mutations of genes HESX1 and LHX4 associated, but accounts for less than 5% of cases.
literature
- CR Pickardt , F. Erhardt, R. Fahlbusch , PC Scriba: Portal Vessels Occlusion. A Cause for Pituitary Insufficiency in Patients with Pituitary Tumors. In: European Journal of Clinical Investigation. (1973); 3, p. 262. PDF
- R. Reynaud, F. Albarel, A. Saveanu, N. Kaffel, F. Castinetti, P. Lecomte, R. Brauner, G. Simonin, J. Gaudart, E. Carmona, A. Enjalbert, A. Barlier, T. Brue: Pituitary Stalk Interruption Syndrome in 83 patients: novel HESX1 mutation and severe hormonal prognosis in malformative forms. In: Eur J Endocrinol. 2011 Apr; 164 (4), pp. 457-465. PMID 21270112 .
