Pittsburgh Compound B
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| Surname | Pittsburgh compound B | ||||||||||||
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2- (4 '- [ 11 C] methylaminophenyl) -6-hydroxybenzothiazole |
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| Molecular formula | C 14 H 12 N 2 OS | ||||||||||||
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| Molar mass | 256.32 g mol −1 | ||||||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||
Pittsburgh Compound B (PiB) is a radiopharmaceutical that can be used as a radioactive analogue of thioflavin T in positron emission tomography to image beta-amyloid plaques in nerve tissue . Because of this feature, Pittsburgh compound B can be used in investigations into Alzheimer's disease . The compound was developed by researchers from the University of Pittsburgh in collaboration with Uppsala University , the Karolinska Institute and Huddinge University.
Extraction and presentation
PiB can be prepared from 2- (4'-aminophenyl) -6-hydroxybenzothiazole by [ 11 C] methylation with methyl triflate , which is converted, purified and reformulated by solid phase extraction in a high-performance liquid chromatography loop (HPLC loop) .
Web links
- Pittsburgh compound B at sciencedirect.com
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- Jump up ↑ William E. Klunk, Henry Engler, Agneta Nordberg, Yanming Wang, Gunnar Blomqvist, Daniel P. Holt, Mats Bergström, Irina Savitcheva, Guo-Feng Huang, Sergio Estrada, Birgitta Ausén, Manik L. Debnath, Julien Barletta, Julie C Price, Johan Sandell, Brian J. Lopresti, Anders Wall, Pernilla Koivisto, Gunnar Antoni, Chester A. Mathis, Bengt Långström: Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. In: Annals of Neurology. 55, 2004, p. 306, doi : 10.1002 / ana.20009 .
- ↑ Ian Diner, Jeromy Dooyema, Marla Gearing, Lary C. Walker, Nicholas T. Seyfried: Generation of Clickable Pittsburgh Compound B for the detection and capture of β-amyloid in Alzheimer's Disease Brain. In: Bioconjugate Chemistry. 28, 2017, p. 2627, doi : 10.1021 / acs.bioconjchem.7b00500 .
- ^ Decision Resources Inc: The SAGE Handbook of Healthcare . SAGE, 2008, ISBN 978-1-84787-700-0 , pp. 660 ( limited preview in Google Book search).
- ^ IEEE Conference Publication: Synthesis optimization of pittsburgh compound B by the captive solvent method - IEEE Conference Publication , access date : January 23, 2018.