Pleconaril

Structural formula
General
Non-proprietary name	Pleconaril
other names	3- {3,5-Dimethyl-4- [3- (3-methyl-1,2-oxazol-5-yl) propoxy] phenyl} -5- (trifluoromethyl) -1,2,4-oxadiazole ( IUPAC )
Molecular formula	C 18 H 18 F 3 N 3 O 3
External identifiers / databases
EC number	683-423-9
ECHA InfoCard	100.208.947
PubChem	1684
ChemSpider	1621
DrugBank	DB05105
Wikidata	Q770293
Drug information
ATC code	J05 AX06
Drug class	Antiviral
properties
Molar mass	381.35 g mol −1
Physical state	firmly
Melting point	61-62 ° C
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances danger
H and P phrases	H: 301-413
	P: ?
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Pleconaril is a drug that is used as a virostat . It is an orally administered capsid blocker of the third generation. No commercial preparations are currently available.

pharmacology

Rhinovirus capsid protein VP1 (in green) with pleconaril

Pleconaril interacts with the capsid protein VP1 of rhinoviruses and enteroviruses . Here it competes with the pocket factor and occupies the hydrophobic pocket in its place. This leads to a conformational change in the virus capsid. As a result, the binding to cellular receptors and the uncoating of the rhino and enteroviruses is prevented.

literature

Ma, Nafziger, Rhodes, Liu, Bertino: Drug metabolism and the disposition: the biological fate of chemicals . 2006; 34 (5); 783-785.
Diana, Rudewicz, Pevear, Nitz, Aldoos, et al .: J. Med. Chem. 1995; 38; 1355-1371.

Individual evidence

^ The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 1299, ISBN 978-0-911910-00-1 .
↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . What is shown is a labeling of 1,2,4-oxadiazole, 3- [3,5-dimethyl-4- [3- (3-methyl-5-isoxazolyl) propoxy] phenyl] -5- ( which is derived from a self-classification by the distributor trifluoromethyl) - in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on January 13, 2020.

↑ ABDA database (as of December 5, 2009).

[MerckIndex-1] The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 1299, ISBN 978-0-911910-00-1 .

[2] Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . What is shown is a labeling of 1,2,4-oxadiazole, 3- [3,5-dimethyl-4- [3- (3-methyl-5-isoxazolyl) propoxy] phenyl] -5- ( which is derived from a self-classification by the distributor trifluoromethyl) - in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on January 13, 2020.

[3] ABDA database (as of December 5, 2009).