Pleconaril
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Non-proprietary name | Pleconaril | |||||||||||||||||||||
other names |
3- {3,5-Dimethyl-4- [3- (3-methyl-1,2-oxazol-5-yl) propoxy] phenyl} -5- (trifluoromethyl) -1,2,4-oxadiazole ( IUPAC ) |
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Molecular formula | C 18 H 18 F 3 N 3 O 3 | |||||||||||||||||||||
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Drug information | ||||||||||||||||||||||
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properties | ||||||||||||||||||||||
Molar mass | 381.35 g mol −1 | |||||||||||||||||||||
Physical state |
firmly |
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Melting point |
61-62 ° C |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Pleconaril is a drug that is used as a virostat . It is an orally administered capsid blocker of the third generation. No commercial preparations are currently available.
pharmacology
Pleconaril interacts with the capsid protein VP1 of rhinoviruses and enteroviruses . Here it competes with the pocket factor and occupies the hydrophobic pocket in its place. This leads to a conformational change in the virus capsid. As a result, the binding to cellular receptors and the uncoating of the rhino and enteroviruses is prevented.
literature
- Ma, Nafziger, Rhodes, Liu, Bertino: Drug metabolism and the disposition: the biological fate of chemicals . 2006; 34 (5); 783-785.
- Diana, Rudewicz, Pevear, Nitz, Aldoos, et al .: J. Med. Chem. 1995; 38; 1355-1371.
Individual evidence
- ^ The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 1299, ISBN 978-0-911910-00-1 .
- ↑ harmonized classification for this substance . What is shown is a labeling of 1,2,4-oxadiazole, 3- [3,5-dimethyl-4- [3- (3-methyl-5-isoxazolyl) propoxy] phenyl] -5- ( which is derived from a self-classification by the distributor trifluoromethyl) - in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on January 13, 2020. There is not yet a
- ↑ ABDA database (as of December 5, 2009).