Prochlorperazine

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Structural formula
Structure of prochlorperazine
General
Non-proprietary name Prochlorperazine
other names

2-chloro-10- [3- (4-methyl-1-piperazinyl) propyl] -10 H -phenothiazine

Molecular formula C 20 H 24 ClN 3 S
External identifiers / databases
CAS number
  • 58-38-8
  • 84-02-6 (hydrogen maleate )
PubChem 4917
DrugBank DB00433
Wikidata Q2359690
Drug information
ATC code

N05 AB04

properties
Molar mass 373.943 g · mol -1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Prochlorperazine is a dopamine receptor - antagonist from the group of phenothiazines , predominantly nausea and vomiting (as antiemetic ) and migraine , rarer than antipsychotic is used.

Indications

Prochlorperazine is used as an anti-emetic to treat nausea and vomiting , as a neuroleptic to treat schizophrenia and anxiety disorders, and to treat migraines .

Side effects and interactions

For example, the drug must not be used at the same time as astemizole , cisapride and terfenadine .

Trade names

Monopreparations : Compazine (USA)

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ^ RJ Gralla et al .: Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines . In: Journal of Clinical Oncology . 17, No. 9, September 1999, pp. 2971-2994. PMID 10561376 .
  3. ^ JF Casey, JJ Lasky, CJ Klett, LE Hollister: Treatment of schizophrenic reactions with phenothiazine derivatives. A comparative study of chlorpromazine, triflupromazine, mepazine, prochlorperazine, perphenazine, and phenobarbital . In: American Journal of Psychiatry . 117, August 1960, pp. 97-105. doi : 10.1176 / ajp.117.2.97 . PMID 13808146 .
  4. ^ HC Siow, WB Young, SD Silberstein: Neuroleptics in headache . In: Headache . 45, No. 4, April 2005, pp. 358-71. doi : 10.1111 / j.1526-4610.2005.05074.x . PMID 15836574 .