Proflavine

Structural formula
General
Surname	Proflavine
other names	3,6-diaminoacridine
Molecular formula	C 13 H 11 N 3
Brief description	yellow solid
External identifiers / databases
EC number	202-172-4
ECHA InfoCard	100.001.976
PubChem	7099
ChemSpider	6832
DrugBank	DB01123
Wikidata	Q420454
properties
Molar mass	210.25 g mol −1
Physical state	firmly
Melting point	284-286 ° C ; 270 ° C (hydrochloride);
pK s value	9.7
solubility	readily soluble in ethanol and water: 500 g · l −1 ; insoluble in benzene and ether;
safety instructions
GHS labeling of hazardous substances Hemisulfate salt hydrate Caution
H and P phrases	H: 315-319-335
	P: 261-305 + 351 + 338
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Proflavine is an aromatic heterocyclic compound. At room temperature it is a brown-green powder. The structure of proflavine is based on an acridine backbone. Proflavin is sold as chloride or hemisulfate and is used as an antiseptic and disinfectant .

properties

The melting point of proflavine is 285 ° C. It is readily soluble in water because the heterocyclic nitrogen atom is protonated in aqueous solution. This means that the proflavine is ionic. It shows yellow fluorescence in aqueous solution . The absorption maximum of proflavine is in aqueous solution and at a pH of 7 at 450 nm.

When introduced into the organism, proflavine acts as an intercalator in the DNA and is therefore potentially mutagenic.

swell

Silke Korn, Michael W. Tausch: Laboratory Simulation for Coupled Cycles of Photosynthesis and Respiration. In: Journal of Chemical Education. Vol. 78 no. September 9 , 2001; doi : 10.1021 / ed078p1238 .

Individual evidence

↑ ^a ^b ^c ^d ^e Entry on Proflavine in the Hazardous Substances Data Bank , accessed on July 29, 2012.
↑ Data sheet 3,6-Diaminoacridine hydrochloride, Dye content 95% from Sigma-Aldrich , accessed on July 12, 2012 ( PDF ).
↑ ^a ^b Data sheet Proflavine hemisulfate salt hydrate, powder at Sigma-Aldrich , accessed on July 12, 2012 ( PDF ).
↑ ( page no longer available , search in web archives )@1@ 2

[hsdb-1] Entry on Proflavine in the Hazardous Substances Data Bank , accessed on July 29, 2012.

[SigmaHCL-2] Data sheet 3,6-Diaminoacridine hydrochloride, Dye content 95% from Sigma-Aldrich , accessed on July 12, 2012 ( PDF ).

[Sigma-3] Data sheet Proflavine hemisulfate salt hydrate, powder at Sigma-Aldrich , accessed on July 12, 2012 ( PDF ).

[4] ( page no longer available , search in web archives )@1@ 2