Promyelocyte

Promyelocyte (middle, slightly right) in a bone marrow smear

The promyelocyte is a precursor cell of granulocytopoiesis , i.e. the formation of the granulocytes belonging to the white blood cells . The round to egg-shaped promyelocyte is 15 to 25 µm in size, making it the largest cell in granulocytopoiesis and the second largest cell in the bone marrow after the megakaryocyte . It arises from the myeloblast and has a lower core-plasma ratio than its predecessor. The cytoplasm is somewhat more basophilic than the myeloblast and contains azurophilic granules , which are mainly found in the Golgi zone on the cell nucleus and functionally represent lysosomes . The oval cell nucleus shows a one-sided indentation, a fine network drawing and clear nucleus bodies . Promyelocytes make up about 3% of the cells in the bone marrow. They further differentiate into myelocytes .

literature

↑ ^a ^b Barbara J. Bain and Dieter Huhn: Roche Basic Course in Hematological Morphology . Georg Thieme, Stuttgart 2007, ISBN 978-3-89412-299-7 , p. 96-97 .
^ Renate Lüllmann-Rauch and Friedrich Paulsen: Pocket textbook histology . 4th edition. Georg Thieme, Stuttgart 2012, ISBN 978-3-13-151664-0 , p. 302- .
↑ Axel M. Gressner and Torsten Arndt: Encyclopedia of Medical Laboratory Diagnostics . 2nd Edition. Springer, Berlin 2013, ISBN 978-3-642-12921-6 , pp. 1117 .

[Bain-1] Barbara J. Bain and Dieter Huhn: Roche Basic Course in Hematological Morphology . Georg Thieme, Stuttgart 2007, ISBN 978-3-89412-299-7 , p. 96-97 .

[2] Renate Lüllmann-Rauch and Friedrich Paulsen: Pocket textbook histology . 4th edition. Georg Thieme, Stuttgart 2012, ISBN 978-3-13-151664-0 , p. 302- .

[3] Axel M. Gressner and Torsten Arndt: Encyclopedia of Medical Laboratory Diagnostics . 2nd Edition. Springer, Berlin 2013, ISBN 978-3-642-12921-6 , pp. 1117 .