Basophilia
As basophilia is generally a coloring property of cells , respectively, cell organelles with acidic referred substances or groups of substances. In cytological and histological examinations, these can easily be stained with basic dyes such as methylene blue , hematoxylin , cresyl violet , toluidine blue or thionine blue, violet or metachromatically . See in particular under histology section staining histology .
As basophilia is special and in clinical everyday language also shortens an increase in the number of basophils (short: basophils ) in the blood called. Basophilia in hematology is a form of leukocytosis , which is an increase in the number of white blood cells .
Basophilia in hematology
Basophil granulocytes are produced in the bone marrow and have the same precursor cells as mast cells . They only circulate in the blood for a few minutes and then migrate to the tissues, where they remain for several weeks.
Basophilia is often associated with eosinophilia . Basophilia is caused by allergies and hypersensitivity reactions. In addition, parasitoses often lead to basophilia ( heartworm disease , other diseases caused by roundworms , infestation with ticks or flea allergies ). A hyperlipoproteinemia , which is a metabolic or endocrine disorder with an increase in blood lipids , may also be connected to a basophilia. Basophilic leukemia is a very rare tumor disease . In chronic myeloid leukemia , there is also an increase in the number of basophils.
Basopenia
Basopenia is a decrease in the number of basophils in the blood. It is difficult to prove, since the basophil number is already relatively small physiologically. The main cause is increased glucocorticoid levels, either endogenously caused ( stress ) or through administration as a drug.
See also
Individual evidence
- ↑ a b basophilia . In: Norbert Boss (Ed.): Roche Lexicon Medicine . 2nd Edition. Hoffmann-La Roche AG and Urban & Schwarzenberg, Munich 1987, ISBN 3-541-13191-8 , p. 168, cf. also 5th edition 2003
