Propiverine

Structural formula
General
Non-proprietary name	Propiverine
other names	(1-methyl-4-piperidyl) -diphenylpropoxyacetate
Molecular formula	C 23 H 29 NO 3
External identifiers / databases
PubChem	4942
ChemSpider	4773
DrugBank	DB12278
Wikidata	Q904321
Drug information
ATC code	G04 BD06
Drug class	Anticholinergics , antispasmodics
properties
Molar mass	367.49 g · mol -1
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Propiverine is a drug that is used as an anticholinergic and antispasmodic .

use

Propiverine belongs to the group of neurotropic-musculotropic antispasmodics. It is therefore used in urology for (urge) incontinence and increased micturition frequency (excessively frequent emptying of the urinary bladder ).

Mode of action

Propiverine has a dual effect:

an anticholinergic effect, d. H. a competitive inhibitory effect on the acetylcholine-mediated transmission of excitation at the muscarinic receptor , such as atropine (neurotropic effect) and
A direct antispasmodic effect on the smooth muscles, comparable to papaverine , which comes about by inhibiting the calcium influx through the L-type calcium channels in the muscle cells of the smooth muscles (musculotropic effect).

Pharmacokinetics

Due to its long half-life of 14 to 20 hours compared to the other neurotropic-musculotropic antispasmodics, twice daily intake is sufficient.

Side effects

Use can lead to tiredness, gastrointestinal disorders, dry mouth, drop in blood pressure with symptoms of dizziness and, in the case of high doses, a decrease in sweat gland secretion (heat build-up, reddening of the skin).

Trade names

Monopreparations

Mictonetten (DE, CZ, SK), Mictonorm (DE, CZ, SK, BE, GR, IT, TR), Mictonorm Uno (DE), Detrunorm (UK, SI, HR), Detrunorm XL (GB, IE, HR)

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ ABDA database (as of August 5, 2008) of DIMDI.
↑ Deutsches Ärzteblatt 1998; 95 (20): Urinary incontinence: Propiverine is well tolerated . Here online .

[NV-1] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[DIMDI-2] ABDA database (as of August 5, 2008) of DIMDI.

[3] Deutsches Ärzteblatt 1998; 95 (20): Urinary incontinence: Propiverine is well tolerated . Here online .