Proton Potassium Pump

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Proton Potassium Pump
Properties of human protein
Mass / length primary structure 1325 = 1034 + 291 amino acids
Secondary to quaternary structure multipass membrane protein
Gene name ATP4
External IDs
Transporter classification
TCDB 3.A.3.1.2
designation P-ATPase
Enzyme classification
EC, category hydrolase
Response type hydrolysis
Substrate ATP + H 2 O + H + inside + K + outside
Products ADP + phosphate + H + outside + K + inside

The proton potassium pump or H + / K + -ATPase is an enzyme in the parietal cells in the stomach that transports protons out of the cells and simultaneously transports potassium ions into the cell. Here is ATP consumed, so it is a so-called membrane-bound ATPase . If the cell also transports negative chloride ions to the same side, they form hydrochloric acid (HCl) with the protons there . The hydrochloric acid required to kill germs and prepare the nutrients for digestion is produced in the stomach.

The transport equation is:


Proton potassium pump inhibitors are known as proton pump inhibitors .

Individual evidence

  1. 3.A.3 The P-type ATPase (P-ATPase) Superfamily. In: TCDB. Saier Lab Bioinformatics, accessed September 8, 2010 .
  2. UniProt P20648