Proton Potassium Pump
Proton Potassium Pump | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 1325 = 1034 + 291 amino acids | |
Secondary to quaternary structure | multipass membrane protein | |
Identifier | ||
Gene name | ATP4 | |
External IDs |
|
|
Transporter classification | ||
TCDB | 3.A.3.1.2 | |
designation | P-ATPase | |
Enzyme classification | ||
EC, category | 3.6.3.10 , hydrolase | |
Response type | hydrolysis | |
Substrate | ATP + H 2 O + H + inside + K + outside | |
Products | ADP + phosphate + H + outside + K + inside |
The proton potassium pump or H + / K + -ATPase is an enzyme in the parietal cells in the stomach that transports protons out of the cells and simultaneously transports potassium ions into the cell. Here is ATP consumed, so it is a so-called membrane-bound ATPase . If the cell also transports negative chloride ions to the same side, they form hydrochloric acid (HCl) with the protons there . The hydrochloric acid required to kill germs and prepare the nutrients for digestion is produced in the stomach.
The transport equation is:
Inhibitors
Proton potassium pump inhibitors are known as proton pump inhibitors .
Individual evidence
- ↑ 3.A.3 The P-type ATPase (P-ATPase) Superfamily. In: TCDB. Saier Lab Bioinformatics, accessed September 8, 2010 .
- ↑ UniProt P20648