Proton Potassium Pump

Proton Potassium Pump
Properties of human protein
Mass / length primary structure	1325 = 1034 + 291 amino acids
Secondary to quaternary structure	multipass membrane protein
Identifier
Gene name	ATP4
External IDs	OMIM :  137216 UniProt :  P20648 CAS number : 9000-83-3
Transporter classification
TCDB	3.A.3.1.2
designation	P-ATPase
Enzyme classification
EC, category	3.6.3.10 ,  hydrolase
Response type	hydrolysis
Substrate	ATP + H 2 O + H + inside + K + outside
Products	ADP + phosphate + H + outside + K + inside

The proton potassium pump or H ⁺ / K ⁺ -ATPase is an enzyme in the parietal cells in the stomach that transports protons out of the cells and simultaneously transports potassium ions into the cell. Here is ATP consumed, so it is a so-called membrane-bound ATPase . If the cell also transports negative chloride ions to the same side, they form hydrochloric acid (HCl) with the protons there . The hydrochloric acid required to kill germs and prepare the nutrients for digestion is produced in the stomach.

The transport equation is: ${\displaystyle \mathrm {ATP+H_{2}O+H_{in}^{+}+K_{out}^{+}\longrightarrow ADP+P_{i}+H_{out}^{+}+K_{in}^{+}} }$

Inhibitors

Proton potassium pump inhibitors are known as proton pump inhibitors .

Individual evidence

1. ↑ 3.A.3 The P-type ATPase (P-ATPase) Superfamily. In: TCDB. Saier Lab Bioinformatics, accessed September 8, 2010 . 
2. ↑ UniProt P20648