Pterines

According to a proposal by Wolfgang Pfleiderer, natural substances in which the basic structure of the 2-amino-4-oxo-3,4-dihydropteridine, called pterine , appears under the name pterine . Hydrogenated compounds are also included in this group of compounds, e.g. B. 7,8-dihydropterins or 5,6,7,8-tetrahydropterins. Pterins can be classified as a subgroup of pteridines .

Structural formula of pterins, 7,8-dihydropterins and 5,6,7,8-tetrahydropterins: The substituents R ⁶ and R ⁷ can be hydrogen, O-substituted alkyl radicals or oxygen (HO or O =).

Pterins are widespread among living things, where they perform important biological functions. Biogenetically, they arise from the purine nucleotide guanosine triphosphate in several, sometimes complicated, reaction steps. For examples, see the articles Biopterin , Leukopterin , Neopterin , Sepiapterin , Xanthopterin and Folic Acid .

literature

• Wolfgang Pfleiderer, Recent Developments in Pteridine Chemistry, Angew. Chem. 75, 993-1014 (1963), doi : 10.1002 / anie.19630752102 .
• Irmgard Ziegler, Pterine: Pigments, cofactors and signal compounds in cellular interaction, Naturwissenschaften 74, 563-572 (1987), doi : 10.1007 / BF00368513 .

Web links

Wikibooks: Biochemistry and Pathobiochemistry: Biopterin Metabolism  - Learning and Teaching Materials