Queuin
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General | ||||||||||||||||
Surname | Queuin | |||||||||||||||
other names |
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Molecular formula | C 12 H 15 N 5 O 3 | |||||||||||||||
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properties | ||||||||||||||||
Molar mass | 277.28 g mol −1 | |||||||||||||||
Physical state |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Queuin is a heterocyclic organic compound . It is a derivative of the nucleobase guanine . The N 7 atom of guanine is replaced by a C 7 atom and thus forms 7-deazaguanosine , to which a cyclopentene ring has been attached via an aminomethyl group . It occurs as a component of the nucleoside queuosine (Q) in the tRNA .
literature
- Walter R. Farkas: Queuine, The Q-Containing tRNAs and the Enzymes Responsible for Their Formation ; Nucleosides, Nucleotides and Nucleic Acids , 1983 , 2 (1), pp. 1-20 ( doi : 10.1080 / 07328318308078845 ).
- Hiroshi Akimoto, Eiko Imamiya, Takenori Hitaka, Hiroaki Nomura, Susumu Nishimura: Synthesis of Queuine, the Base of Naturally Occurring Hypermodified Nucleoside (Queuosine), and Its Analogues ; J. Chem. Soc., Perkin Trans. 1 , 1988 , pp. 1637-1644 ( doi : 10.1039 / P19880001637 ).
- Charles J. Barnett, Lana M. Grubb: Total Synthesis of Q-Base (Queuine) ; Tetrahedron , 2000 , 56 (47), pp. 9221-9225 ( doi : 10.1016 / S0040-4020 (00) 00895-4 ).
- Florian Klepper: Synthesis of the natural tRNA nucleoside modifications queuosine and archaeosine , dissertation, Munich 2007 ( PDF ; 5.1 MB), pp. 25–28.
- Allen F. Brooks, George A. Garcia, HD Hollis Showalter: A Short, Concise Synthesis of Queuine ; Tetrahedron Letters , 2010 , 51 (32), pp. 4163-4165 ( doi : 10.1016 / j.tetlet.2010.06.008 ; PDF ).
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
Web links
- Entry for Queuine in the Human Metabolome Database (HMDB) , accessed June 12, 2019.