Remoxipride

Structural formula
General
Non-proprietary name	Remoxipride
other names	( S ) -3-bromo- N - (1-ethyl-2-pyrrolidinylmethyl) -2,6-dimethoxybenzamide ( IUPAC )
Molecular formula	C 16 H 23 BrN 2 O 3 (remoxiprid) ; C 16 H 23 BrN 2 O 3 (remoxiprid hydrochloride monohydrate) ;
External identifiers / databases
PubChem	54477
ChemSpider	49195
DrugBank	DB00409
Wikidata	Q1169059
Drug information
ATC code	N05 AL04
Drug class	Atypical neuroleptic
properties
Molar mass	371.27 g · mol -1 (remoxipride) ; 425.75 g · mol -1 (remoxipride · hydrochloride · monohydrate) ;
Physical state	firmly
Melting point	173 ° C
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Remoxiprid is an atypical neuroleptic that was used in psychiatry in the early 1990s . From the chemical structure it is a benzamide .

history

Remoxiprid was approved for the treatment of schizophrenic psychoses from 1991 to the end of 1993 . The trade name of the original preparation was Roxiam ; the daily dose was 150–450 mg (max. 600 mg) in the form of oral capsules, and a solution for injection was also available.

Withdrawal from the market

At the end of 1993, ROXIAM was taken off the market worldwide by the manufacturer when the regulatory approval for Remoxiprid threatened to be revoked. The cause was fatal cases of aplastic anemia , damage to blood formation in the bone marrow caused by remoxipride ( risk 1 in 2000). The risk-benefit ratio of this low-potency neuroleptic was therefore clearly negative.

Individual evidence

^ The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 1401, ISBN 978-0-911910-00-1 .
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[MerckIndex-1] The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 1401, ISBN 978-0-911910-00-1 .

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.