Ruth Ley

from Wikipedia, the free encyclopedia

Ruth E. Ley (* 1970 ) is a British developmental biologist and microbiologist . She investigates the interaction of the host and the microbiome in mammals, the influence of the environment, the genetic disposition and the host's immune system and, conversely, the effect on the health of the host and the development of the microbiome in young children.

Life

Ley grew up as the daughter of an engineer in Surrey, Paris and Palo Alto. She graduated from the University of California, Berkeley , with a bachelor's degree in integrative biology in 1992, worked in national parks in Hawaii, and received her PhD in 2001 from the University of Colorado at Boulder on microbiology in extreme soils. In her dissertation she showed that soil bacteria were also active in high alpine locations in the Rocky Mountains, even in winter. She then studied salt bacteria with Norman Pace in Mexico on a scholarship in astrobiology from NASA and the National Research Council . At the Washington School of Medicine in Seattle, she turned to the human microbiome from 2004 with Jeffrey Gordon , and Gordon's group found a link between the microbiome and obesity in mice. If the intestinal bacteria of ordinary mice were transferred to mice living in a sterile environment without a microbiome, they gained weight, which was even more pronounced in the case of intestinal microbes from overweight mice. Soon afterwards, Ley was also able to demonstrate a difference in the intestinal flora of overweight and normal weight people (overweight people had relatively more Firmicutes compared to Bacteroides , but were similar to that of normal weight people if they lost weight). In 2008 she became an Assistant Professor at Cornell University and in 2013 an Associate Professor. Since 2016 she has been director at the Max Planck Institute for Developmental Biology in Tübingen.

In 2018 she received the Ernst Jung Prize . She received the New Innovation Award from the Director of the National Institutes of Health , received Beckman and Hartwell Research Fellowships, and was a Packard Fellow. In 2013 she received the International Society for Microbial Ecology Young Investigator Award. In 2019 Ley was elected to the European Molecular Biology Organization . In 2020 Ruth Ley was accepted as a member of the National Academy of Sciences Leopoldina in the Microbiology and Immunology Section .

She is married to the Dutch bio-engineer Lars Angenent .

Fonts (selection)

  • with F. Bäckhed, J. Gordon a. a .: Obesity alters gut microbial ecology, Proceedings of the National Academy of Sciences of the USA, Volume 102, 2005, pp. 11070-11075
  • with F. Bäckhed, J. Gordon a. a .: Host-bacterial mutualism in the human intestine, Science, Volume 307, 2005, pp. 1915-1920
  • with PJ Turnbaugh, MA Mahowald, V. Magrini, ER Mardis, J. Gordon: An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, Volume 444, 2006, p. 1027
  • with DA Peterson, J. Gordon: Ecological and evolutionary forces shaping microbial diversity in the human intestine, Cell, volume 124, 2006, pp. 837-848
  • with PJ Turnbaugh, S. Klein, J. Gordon: Microbial ecology: human gut microbes associated with obesity, Nature, Volume 444, 2006, p. 1022
  • with PJ Turnbaugh a. a .: The human microbiome project, Nature, Volume 449, 2007, p. 804
  • with PJ Turnbaugh a. a .: A core gut microbiome in obese and lean twins, Nature, Volume 457, 2009, p. 480
  • with M. Hamady u. a .: Evolution of mammals and their gut microbes, Science, Volume 320, 2008, pp. 1647-1651
  • with L. Wen u. a .: Innate immunity and intestinal microbiota in the development of Type 1 diabetes, Nature, Volume 455, 2008, p. 1109
  • with M. Vijay-Kumar a. a .: Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5, Science, Volume 328, 2010, pp. 228-231
  • with A. Spor, O. Koren: Unraveling the effects of environment and host genotype on the gut microbiome. Nature Reviews Microbiology, Volume 9, 2011, pp. 279-290.
  • with J. Walter: The human gut microbiome: ecology and recent evolutionary changes. Annual Reviews of Microbiology, Volume 65, 2011, pp. 411-429.
  • with C. Huttenhower a. a .: Structure, function and diversity of the healthy human microbiome, Nature, Volume 486, 2012, p. 207

literature

  • Cornelia Stolze, Exploring the Microbial Cosmos, Max Planck Research 2/2017

Web links

personal data
SURNAME Ley, Ruth
ALTERNATIVE NAMES Ley, Ruth E.
BRIEF DESCRIPTION British microbiologist
DATE OF BIRTH 1970