Seed-and-Soil Theory

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The seed-and-soil theory (from English seed = 'seed' and soil = 'arable soil') is a theory from the field of oncology . The seed-and-soil theory provides an explanatory model for the metastasis (settlement) of tumor cells of a primary tumor in certain organs .

description

The seed-and-soil theory states that tumor cells ( seed ) that have settled are distributed over the vascular system , but can only develop into metastases where the tumor cells find particularly favorable conditions ( soil ).

To this day, the seed-and-soil theory of metastasis is largely valid; especially for bone metastases .

History

The English surgeon Stephen Paget proposed the seed-and-soil theory in 1889. He observed in a large number of breast cancers that these disproportionately often lead to bone metastases. He concluded that the target organ - in the example of breast cancer, the skeletal system - plays an essential active role in metastasis. However, Paget explicitly attributed the idea for this theory to Ernst Fuchs .

Individual evidence

  1. ↑ B. Bartling: Tumorigenesis of non-small cell lung cancer: from genetic regulation to tumor-stroma interaction. (PDF; 132 kB) Habilitation thesis, Medical Faculty of the Martin Luther University Halle-Wittenberg, 2009
  2. ↑ G. Layer: Skeletal Metastases. In: J. Freyschmidt, A. Stäbler: Handbuch diagnostic radiology. Springer, 2005, ISBN 978-3-540-26388-3 , pp. 327-338, doi : 10.1007 / 3-540-26388-8_11 .
  3. ^ LA Liotta, EC Kohn: The microenvironment of the tumor-host interface. In: Nature Volume 411, number 6835, May 2001, ISSN  0028-0836 , pp. 375-379, doi: 10.1038 / 35077241 , PMID 11357145 . (Review).
  4. ^ IJ Fidler: Critical determinants of metastasis. In: Seminars in Cancer Biology Volume 12, Number 2, April 2002, ISSN  1044-579X , pp. 89-96, doi: 10.1006 / scbi.2001.0416 , PMID 12027580 . (Review).
  5. ^ Y. Zhang, B. Ma, Q. Fan: Mechanisms of breast cancer bone metastasis. In: Cancer Letters Volume 292, Number 1, June 2010, ISSN  1872-7980 , pp. 1-7, doi: 10.1016 / j.canlet.2009.11.003 , PMID 20006425 . (Review).
  6. ^ S. Paget: The distribution of secondary growths in cancer of the breast. 1889. In: Cancer Metastasis Reviews Volume 8, Number 2, August 1989, ISSN  0167-7659 , pp. 98-101, PMID 2673568 .
  7. ^ S. Paget: The distribution of secondary growths in cancer of the breast. In: The Lancet 1, 1889, pp. 571-573, doi: 10.1016 / S0140-6736 (00) 49915-0 .
  8. ↑ E. Fuchs: The sarcoma of the uveal tract. Graefe's Arch Ophthalmol, XII, Vienna, 1882.
  9. ^ S. Majumder: Stem Cells and Cancer. P. 171 ( limited preview in Google Book search).