Stephen Paget

Stephen Paget FRCS (born July 17, 1855 in London , † May 8, 1926 in Limpsfield , Surrey ) was an English surgeon and oncologist .

Life

Paget was the son of the surgeon and pathologist James Paget and his wife Lydia nee. North. His brother was John Rahere Paget .

Stephen Paget was best known for his article The Distribution Of Secondary Growths In Cancer Of The Breast , published in The Lancet in 1889 . On the basis of this article, he is awarded the so-called seed-and-soil theory . Paget had found in a large number of breast cancers that these disproportionately often lead to bone metastases . It concluded that the target organ plays an essential active role in metastasis. In his hypothesis , Paget suspected that metastasis in the affected organ occurs when the matching tumor cell ( seed ) has a particularly high affinity for the environment ( soil ) surrounding the affected organ . However, he explicitly attributed the idea for this theory to Ernst Fuchs .

On September 17, 1885, Paget married Eleanor Mary Burd (1854-1933). The couple had two daughters.

literature

D. Ribatti, G. Mangialardi, A. Vacca: Stephen Paget and the 'seed and soil' theory of metastatic dissemination. In: Clinical and experimental medicine Volume 6, Number 4, December 2006, pp. 145-149, ISSN 1591-8890 . doi: 10.1007 / s10238-006-0117-4 . PMID 17191105 .

Web links

Stephen Paget's family tree

Individual evidence

^ S. Paget: The distribution of secondary growths in cancer of the breast. 1889. In: Cancer Metastasis Reviews Volume 8, Number 2, August 1989, pp. 98-101, ISSN 0167-7659 . PMID 2673568 .
^ S. Paget: The distribution of secondary growths in cancer of the breast. In: The Lancet 1, 1889, pp. 571-573. doi: 10.1016 / S0140-6736 (00) 49915-0
↑ G. Layer: Skeletal Metastases. In: J. Freyschmidt, A. Stäbler: Handbuch diagnostic radiology. Verlag Springer, 2005, pp. 327–338, ISBN 978-3-540-26388-3 doi : 10.1007 / 3-540-26388-8_11
↑ E. Fuchs: The sarcoma of the uveal tract. Graefe's Arch Ophthalmol, XII, Vienna, 1882.
^ S. Majumder: Stem Cells and Cancer. P. 171 ( limited preview in Google Book search).

personal data
SURNAME	Paget, Stephen
BRIEF DESCRIPTION	British surgeon and oncologist
DATE OF BIRTH	July 17, 1855
PLACE OF BIRTH	London
DATE OF DEATH	May 8, 1926
Place of death	Limpsfield , Surrey

[PMID2673568-1] S. Paget: The distribution of secondary growths in cancer of the breast. 1889. In: Cancer Metastasis Reviews Volume 8, Number 2, August 1989, pp. 98-101, ISSN 0167-7659 . PMID 2673568 .

[2] S. Paget: The distribution of secondary growths in cancer of the breast. In: The Lancet 1, 1889, pp. 571-573. doi: 10.1016 / S0140-6736 (00) 49915-0

[3] G. Layer: Skeletal Metastases. In: J. Freyschmidt, A. Stäbler: Handbuch diagnostic radiology. Verlag Springer, 2005, pp. 327–338, ISBN 978-3-540-26388-3 doi : 10.1007 / 3-540-26388-8_11

[4] E. Fuchs: The sarcoma of the uveal tract. Graefe's Arch Ophthalmol, XII, Vienna, 1882.

[5] S. Majumder: Stem Cells and Cancer. P. 171 ( limited preview in Google Book search).