Serine Protein Kinase ATM
| Serine Protein Kinase ATM | ||
|---|---|---|
| other names |
ATM Serine / Threonine Kinase; Ataxia Telangiectasia Mutated; AT Mutated; EC 2.7.11.1; TEL1; AT1; ATA; Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C, And D); TEL1, Telomere Maintenance 1, homolog; Serine protein kinase ATM; Homolog (S. cerevisiae); Telomere Maintenance 1; AT Mutated; TELO1; ATDC; ATE; ATC; ATD |
|
| Properties of human protein | ||
| Mass / length primary structure | 3056 amino acids, 350687 Da | |
| Secondary to quaternary structure | Dimer / tetramer (inactive), monomer (active) | |
| Identifier | ||
| Gene name | ATM | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.7.11.1 , protein kinase | |
| Response type | Phosphorylation | |
| Substrate | (Ser / Thr) protein + ATP | |
| Products | Phospho (Ser / Thr) protein + ADP | |
| Occurrence | ||
| Parent taxon | Animals, mushrooms | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 472 | 11920 |
| UniProt | Q13315 | Q62388 |
| PubMed search | 472 |
11920
|
The serine protein kinase ATM is an enzyme in the nucleus of animal and fungal cells. It acts as a sensor for DNA damage, especially double-strand breaks . In the event of damage from UV radiation , ATM can be activated indirectly via ATR ( Ataxia telangiectasia and Rad3-related protein ).
ATM initiates signal cascades for the production of DNA repair proteins . If severely damaged, it can stop the cell cycle and cause cell death . In humans, ATM is expressed in many tissue types and has additional functions in allele exclusion of B-cell maturation and possibly in vesicle transport . Mutations in the ATM - gene responsible for ataxia telangiectasia and contribute to the risk of several types of leukemia , breast cancer and lung cancer .
The term ATM is the abbreviation of Ataxia Telangiectasia Mutated .
One inhibitor of ATM kinase is caffeine .
literature
- Tichý A, Vávrová J, Pejchal J, Rezácová M: Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response . In: Acta Medica (Hradec Králové) . 53, No. 1, 2010, pp. 13-7. PMID 20608227 .
- Pandita TK: ATM function and telomere stability . In: Oncogene . 21, No. 4, January 2002, pp. 611-8. doi : 10.1038 / sj.onc.1205060 . PMID 11850786 .
- Czornak K, Chughtai S, Chrzanowska KH: Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair . In: J. Appl. Genet. . 49, No. 4, 2008, pp. 383-96. PMID 19029686 .
Individual evidence
- ↑ Orthologist at eggNOG
- ↑ UniProt Q13315
- ↑ Mandriota SJ, Buser R, Lesne L, et al. : Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells . In: Journal of Biological Chemistry . 285, No. 17, April 2010, pp. 13092-106. doi : 10.1074 / jbc.M109.078360 . PMID 20177072 .
- ↑ Lo YL, Hsiao CF, Jou YS, et al. : ATM polymorphisms and risk of lung cancer among never smokers . In: Lung Cancer . 69, No. 2, August 2010, pp. 148-54. doi : 10.1016 / j.lungcan.2009.11.007 . PMID 20004998 .
- ↑ Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT: Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin . In: Cancer Res . 58, No. 19, October 1998, pp. 4375-82. PMID 9766667 .
- ↑ Stiff T, Walker SA, Cerosaletti K, et al. : ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling . In: EMBO J. . 25, No. 24, December 2006, pp. 5775-82. doi : 10.1038 / sj.emboj.7601446 . PMID 17124492 . PMC 1698893 (free full text).
- ↑ Blasina A, Price BD, Turenne GA, McGowan CH: Caffeine Inhibits the checkpoint kinase ATM . In: Curr. Biol . 9, No. 19, October 1999, pp. 1135-8. PMID 10531013 .
Web links
- Matthews L: ATM mediated response to DNA double-strand break. In: reactome.org. EBI, November 18, 2003, accessed October 16, 2010 .
- Hoffmann, I, Khanna, K, O'Connell, M, Walworth, N, Yen, TJ: Cell Cycle Checkpoints. In: reactome.org. EBI, January 1, 2005, accessed October 16, 2010 .