Stephan Grabbe

from Wikipedia, the free encyclopedia
Stephan Grabbe

Stephan Grabbe (born July 7, 1961 in Herford ) is a German physician, university professor for dermatology , venereology and allergology , director of the dermatology clinic and polyclinic of the university medicine department at Johannes Gutenberg University Mainz . He is known for his work in the fields of the biology of antigen presentation , in particular the function of dendritic cells , the structure, kinetics and dynamics of cell-cell interaction during antigen presentation and immunotherapy , especially of malignant melanoma .

Life

Grabbe began studying medicine at the University of Münster in 1980. In 1982 he also enrolled there for philosophy, for which he completed his basic studies in 1984. In 1987 he was licensed as a doctor and in the same year received his doctorate in medicine with summa cum laude . During his studies, he completed a two-semester course at the University of Wales , College of Medicine in Cardiff, Great Britain (DAAD scholarship). In 1988 he completed the American State Examination in Medicine (FMGEMS). 1989-92 he worked as a Postdoctoral Research Fellow at the Department of Dermatology, Wellman Laboratories of Photomedicine, & MGH-Harvard Cutaneous Biology Research Center at Harvard Medical School , Boston. From 1992 to 1994 he was a research assistant at the Center for Dermatology at the University of Münster, where in 1994 he took over the management of his own working group to establish a research laboratory for dermatological immunology and tumor immunology. In 1996 Grabbe completed his habilitation in Münster and received the Venia legendi . In the same year he became a senior physician and took over the management of the phlebological outpatient clinic / ulcer consultation with the personal clinical focus: general dermatology, photodermatology, immunodermatology, allergology, phlebology and chronic wounds. 1998–99 was a Grabbe Heisenberg fellow of the German Research Foundation and a visiting scientist at the Skin Disease Research Center, Brigham and Womens' Hospital, Harvard University , Boston. In 2000 he received the call to a C3 professor for dermatology and dermatological oncology of the University of Münster. 2003-07 Grabbe had a C4 professorship at the Chair of Dermatology, Venereology and Allergology at the University of Duisburg-Essen , combined with the position as director of the Clinic and Polyclinic for Dermatology, Venereology and Allergology. In 2007 he switched to a W3 professorship, chair of dermatology, venereology and allergology at Johannes Gutenberg University Mainz. He specializes in general dermatology, dermato-onocology, immunodermatology, phlebology and chronic wounds. Grabbe has been head of the "Natural Science and Medical Research Center" (NMFZ) at Johannes Gutenberg University Mainz since 2009, since 2010 Deputy Spokesman for the "Research Center Immunology" (FZI) at Johannes Gutenberg University Mainz, and since 2010 board member of the "Center for Thrombosis Research and Hemostaseology" "(CTH) of the Johannes Gutenberg University Mainz, since 2011 Deputy Spokesman of the" University Tumor Center "(UCT) of the University Medical Center Mainz and was a member of the Senate of the Johannes Gutenberg University Mainz from 2008 to 2011.

Grabbe's current areas of activity include management: management of the university dermatology clinic, clinical care: activity as a dermatologist with a focus on dermato-oncology, clinical research: management of clinical studies on the immunotherapy of skin tumors, therapy of inflammatory skin diseases, basic research: management of a research laboratory for immunodermatology and tumor -Immunology, teaching: lectures and internships in the fields of dermatology and immunology for medical students.

Scientific contribution

Grabbe was able to prove for the first time that dendritic cells (“dendritic cells”, DC) of the skin are of crucial importance for the generation of tumor immune responses. He was one of the first scientists to use DC in the treatment of advanced melanoma in patients. The immunotherapy of melanoma has also been a focus of scientific work for many years, both in the laboratory and in the clinical testing of new treatment methods in patients. Together with other scientists, he demonstrated that DCs in the skin are in close contact with nerve cells and that their function can be influenced by them. He also showed that DC have a special type of physical interaction with T cells (“immunological synapse”), which differs significantly from the way in which, for example, B cells interact with T cells. Integrins and selectins are of great importance for this interaction, but also for the function of DC in general and for the migration of cells from the blood into tissue.

In addition to the analysis of the function of dendritic cells, Grabbe also deals scientifically with the fundamentals of the development of allergies and autoimmune diseases in the skin. Here he was able to show, for example, that contact allergens, in addition to their property of activating the immune system in an allergen-specific manner, must also have the ability to non-specific activation of inflammatory processes in order to be able to act as an allergen at all.

Research projects

As Director of the Dermatology Clinic at Mainz University Medical Center, Grabbe heads a basic scientific research laboratory with around 50 employees, whose main focus is on research into the immunological basis of skin diseases , but also the function of the immune system in general. There is particular expertise in the areas of dendritic cells / antigen presentation and regulatory T cells . The clinic also operates a clinical research center in which more than 50 clinical studies are carried out annually in the field of all relevant skin diseases and skin tumors. The dermatology clinic raises third-party funding of around 3 million euros annually. Scientists at the clinic are involved in three special research areas funded by the German Research Foundation (SFB1066, SFB TR156, SFB TR128) and two internal university research focal points, the "Research Center Immunology" and the "Center for Thrombosis Research and Haemostaseology".

Grabbe has been deputy head of the Collaborative Research Center SFB 1066 "Nanodimensional Therapeutics for Tumor Therapy" at Johannes Gutenberg University since 2013 and, since 2015, deputy head of the Collaborative Research Center SFB TR156 "The skin as sensor and effector organ orchestrating local and systemic immune reactions" at the Universities of Heidelberg, Mainz and Tübingen.

Membership in international scientific associations

Grabbe is a member of more than 10 medical-scientific societies, u. a. since 2009 member of the board of the "Arbeitsgemeinschaft Dermatologische Onkologie" (ADO), member of the editorial board of several national and international journals and reviewer for a number of scientific journals and research funding organizations.

Publications

Grabbe has published more than 400 specialist articles in medical journals. The total “impact points” of the published work are approx. 200 as first author, approx. 150 as last author, approx. 450 as co-author. Total “citations” (ResearchGate) amount to approx. 10,000.

ResearchGate publication list

Web links

Individual evidence

  1. ↑ S. Grabbe CV
  2. ↑ S. Grabbe, S. Brūvers, RL Gallo, TL Knisely, R. Nazareno, RD Gran Stone: tumor antigen presentation by murine epidermal cells. In: J Immunol. 146, 1991, pp. 2656-2661.
  3. ↑ FO Nestle, p Alijagic, M. Gilliet, Y. Sun, R. Dummer, G. Castle, D. Damage village: Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. In: Nat. Med. 4, 1998, pp. 328-332.
  4. ↑ D. Schadendorf, S. Ugurel, B. Schuler-Thurner, FO Nestle, A. Enk, EB Bröcker, S. Grabbe, W. Rittgen, L. Edler, A. Sucker, C. Zimpfer -rechner, T. Berger , J. Kamarashev, G. Burg, H. Jonuleit, A. Tüttenberg, JC Becker, P. Keikavoussi, E. Kämpgen, G. Schuler, DC study group of the DeCOG: Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG. In: Ann Oncol. 17, 2006, pp. 563-570.
  5. ^ J. Hosoi, GF Murphy, CL Egan, EA Lerner, S. Grabbe, A. Asahina, RD Granstein: Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. In: Nature. 363, 1993, pp. 159-163.
  6. ↑ M. Gunzer, C. Weishaupt, A. Hillmer, Y. Basoglu, P. Friedl, KE Dittmar, W. Kolanus, G. Varga, S. Grabbe: A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo. In: Blood. 104, 2004, pp. 2801-2809.
  7. ^ S. Balkow, S. Heinz, P. Schmidbauer, W. Kolanus, B. Holzmann, S. Grabbe, M. Laschinger: LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming. In: Blood. 116, 2010, pp. 1885-1894.
  8. ↑ S. Varga, S. Balkow, MK Wild, A. Stadtbaeumer, M. Krummen, T. Rothoeft, T. Higuchi, S. Beissert, K. Wethmar, K. Scharffetter-Kochanek, D. Vestweber, S. Grabbe: Active MAC-1 (CD11b / CD18) on DCs inhibits full T-cell activation. In: Blood. 109, 2007, pp. 661-669.
  9. ↑ GG Pendl, C. Robert, M. Steinert, R. Thanos, R. Eytner, E. Borges, MK Wild, JB Lowe, RC Fuhlbrigge, TS Kupper, D. Vestweber, S. Grabbe: Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selection glycoprotein ligand 1. In: Blood. 99, 2002, pp. 946-956.
  10. Jump up ↑ S. Grabbe, M. Steinert, K. Mahnke, A. Schwarzt, TA Luger, T. Schwarz: Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. In: J Clin Invest. 98, 1996, pp. 1158-1164.
  11. ↑ K. Loser , A. Mehling, S. Loeser, J. Apelt, A. Kuhn, S. Grabbe, T. Schwarz, JM Penninger, S. Beissert: Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. In: Nat. Med. 12, 2006, pp. 1372-1379.
  12. ^ ResearchGate citations
personal data
SURNAME Grabbe, Stephan
BRIEF DESCRIPTION German internist and laboratory doctor
DATE OF BIRTH July 7, 1961
PLACE OF BIRTH Herford