Stephen G. Young

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Stephen G. Young (* 1952 ) is an American medical doctor (originally a cardiologist ).

Life

Young received his bachelor's degrees in the history of science and philosophy of science from Princeton University in 1974 and his M.D. in medicine from Washington University in 1978 . From 1983 to 1985 he was a cardiologist at the Veterans Administration Medical Center in San Diego and from 1984/85 an instructor and from 1986 assistant professor at the University of California, San Diego . In 1987 he became Assistant Professor, 1990 Associate Professor and 1996 Professor of Medicine at the University of California, San Francisco . He was there at the Cardiovascular Research Institute (of which he became Associate Director in 2004) and from 1993 to 2004 director of research in cardiology at San Francisco General Hospital. Since 2004 he has been Professor of Medicine at the University of California, Los Angeles (UCLA), (David Geffen School of Medicine).

Young pioneered the development and use of knockout mouse technology to study physiological and biochemical processes and related diseases such as cancer, atherosclerosis , hypertriglyceridemia, and progeria . The latter disease is caused by errors in the normal post-translational modification of a component of the cell nucleus wall ( lamin ) by a cholesterol compound, as Young showed in the mouse model. A drug originally developed for cancer therapy was able to relieve progeria symptoms in the mouse model.

With scientists in Gothenburg (Sahlgrenska Academy) he found new starting points for cancer therapy (e.g. lung cancer) by showing in a mouse model with special knockout mouse lines that the failure of certain enzymes that are necessary for the conversion of certain endogenous proteins into a tumor inducing form are necessary, suppressed the development of tumors in the mouse model.

His laboratory produced numerous knockout mouse variants that were used in laboratories around the world.

In 2010 he received the Ernst Jung Prize and in 2016 he was elected to the National Academy of Sciences . He is an honorary doctorate from the University of Gothenburg .

Web links

Individual evidence

  1. ↑ Fong, Frost, Meta, Quiao, Coffinier, Yang, Young: A Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria . In :, Science , Volume 311, 2006, p. 1621
  2. ↑ Potential new target for cancer treatment - suppressed enzyme GGtase1, which is used for the cancer-causing modification of CAAX proteins. University of Gothenburg, May 7, 2007, accessed June 29, 2017 .
  3. ↑ Liu, Sjögren, Karlsson, Ibrahim, Andersson, Oloffson, Wahlström, Dahlin, Yu, Chen, Yang, Young, Bergö: Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer . In: Proc. Nat. Acad. Sci. , Volume 107, 2010, p. 6471, PMID 20308544
personal data
SURNAME Young, Stephen G.
BRIEF DESCRIPTION American medic
DATE OF BIRTH 1952