Strep thorn nose
| Streptococcus DNAse | ||
|---|---|---|
| Mass / length primary structure | 303/384 amino acids | |
| Identifier | ||
| Gene name (s) | sdc; sda | |
| Drug information | ||
| ATC code | B06 AA55 | |
| Drug class | Anticoagulants | |
| Enzyme classification | ||
| EC, category | 3.1.21.1 , deoxyribonuclease | |
| Response type | Cleavage of two nucleotides | |
| Substrate | DNA | |
| Products | 2 DNA | |
| Occurrence | ||
| Parent taxon | Streptococci | |
| Orthologue | ||
| S. dysgalactiae ssp. equisimilis | S. pyogenes | |
| Entrez | 13901203 | |
| UniProt | P26295 | O33735 |
| PubMed search | 13901203 |
|
Streptodornase (from Strepto coccus D es o xy r ibo n ucle ase ) is a deoxyribonuclease I (DNase I) obtained from streptococci .
In 1903 Torasaburi Araki (1866–1942) discovered the streptodornase and in 1948 it was represented in crystalline form by Moses Kunitz (1887–1978) from bovine pancreas .
In 1949 William S. Tillett and Lauritz Royal Christensen received the Albert Lasker Basic Medical Research Award for the discovery and purification of streptodornase (and streptokinase) .
Streptodornase can break down large DNA molecules as well as deoxyribonucleoproteins , which make up the largest proportion of pus and necrotic tissue. It is therefore used in conjunction with streptokinase to treat necrotic and infected festering wounds . The wound encrustation is dissolved here. The name of a corresponding medicinal product with proportions of 4: 1 streptokinase: Streptodornase is Varidase ® (manufacturer: Riemser ).
Individual evidence
- ^ A b Wolf-Dieter Müler-Jahncke, Christoph Friedrich, Ulrich Meyer: Medicinal history . 2nd, revised and expanded edition. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart 2005, ISBN 978-3-8047-2113-5 , p. 117 .
- ^ Albert Lasker Basic Medical Research Award 1949 Winners at the Lasker Foundation (laskerfoundation.org); accessed on February 15, 2016
