Platelet selectin
P-selectin | ||
---|---|---|
other names |
CD62 antigen-like family member P, Granule membrane protein 140, GMP-140 |
|
Properties of human protein | ||
Mass / length primary structure | 830 amino acids , 90,834 Da | |
Identifier | ||
External IDs | ||
Orthologue (human) | ||
Entrez | 6403 | |
Ensemble | ENSG00000174175 | |
UniProt | P16109 | |
Refseq (mRNA) | NM_003005.3 | |
Refseq (protein) | NP_002996.2 | |
PubMed search |
6403
|
Platelet selectin (synonym P-selectin , P-selectin , CD62P from English platelet 'thrombocyte') is a surface protein from the group of selectins .
properties
P-selectin is a lectin and participates in cell adhesion in an immune reaction . It mediates Ca 2+ -dependent cell contacts between leukocytes and endothelial cells or platelets by binding to sialyl-Lewis X . It is stored in alpha granules and Weibel-Palade bodies in the endothelial cells until the endothelial cell is activated . It then participates in the rolling of the leukocytes along the cell surface by binding to PSGL1 . P-selectin is glycosylated and palmitoylated .
P-selectin is involved in the decreased blood flow in sickle cell anemia .
Web links
Individual evidence
- ↑ A. Kutlar, SH Embury: Cellular adhesion and the endothelium: P-selectin. In: Hematology / oncology clinics of North America. Volume 28, Number 2, April 2014, pp. 323-339, doi : 10.1016 / j.hoc.2013.11.007 , PMID 24589269 .