Triokinase
Triokinase | ||
---|---|---|
other names |
|
|
Properties of human protein | ||
Mass / length primary structure | 575 amino acids, 58,947 Da (isoform 1) |
|
Identifier | ||
Gene name | TKFC | |
External IDs | ||
Enzyme classification | ||
EC, category | 2.7.1.28 | |
Orthologue | ||
human | House mouse | |
Entrez | 26007 | 225913 |
Ensemble | ENSG00000149476 | ENSMUSG00000034371 |
UniProt | Q3LXA3 | Q8VC30 |
Refseq (mRNA) | NM_015533 | NM_145496 |
Refseq (protein) | NP_056348 | NP_663471 |
Gene locus | Chr 11: 61.33 - 61.35 Mb | Chr 19: 10.59-10.61 Mb |
PubMed search | 26007 |
225913
|
Triokinase ( TK , also called triose kinase ) is an enzyme that catalyzes the phosphorylation of dihydroxyacetone and glyceraldehyde . The metabolic products are further processed in glycolysis .
properties
There are three possible ways to further convert D- glyceraldehyde, the phosphorylation of D -glyceraldehyde with the aid of triokinase being the preferred way due to its low K m value (0.01 mM ). About 90% of the D- glyceraldehyde formed from fructose is metabolized in this way. In addition, the triokinase is highly active in the mammalian liver. At a D- glyceraldehyde concentration of 10 mM, the ATP used for phosphorylation is used up in a liver cell .
Reactions
1) Dihydroxyacetone is phosphorylated to dihydroxyacetone phosphate with the help of triose kinase while consuming ATP .
literature
- Jeremy M. Berg, John L. Tymoczko, Lubert Stryer: Stryer Biochemistry. 7th edition. Springer-Verlag, Berlin / Heidelberg 2014, ISBN 978-3-8274-2988-9 , p. 473.
Individual evidence
- ↑ Ernest Lindbergh: Hemolytic Anemia in Disorders of Red Cell Metabolism . Springer Science & Business Media, 2012, ISBN 978-1-4684-2457-7 , p. 13 ( limited preview in Google Book search).
- ↑ D. Burman, JB Holton: Inherited Disorders of Carbohydrate Metabolism: Monograph based upon Proceedings of the Sixteenth Symposium of The Society for the Study of Inborn Errors of Metabolism . Springer Science & Business Media, 2012, ISBN 978-94-009-9215-3 ( limited preview in Google book search).
- ↑ Peter J. O'Brien, William Robert Bruce: Endogenous Toxins, 2 Volume Set: Targets for Disease Treatment and Prevention . John Wiley & Sons, 2009, ISBN 978-3-527-32363-0 , pp. 189 ( limited preview in Google Book search).