UDP-glucose-6-dehydrogenase
| UDP-glucose-6-dehydrogenase | ||
|---|---|---|
|
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| UDP-glucose dehydrogenase hexamer, human according to PDB 2QG4 | ||
|
Existing structural data: s. UniProt |
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| Properties of human protein | ||
| Mass / length primary structure | 494 amino acids | |
| Secondary to quaternary structure | Homohexamer | |
| Identifier | ||
| Gene name | UGDH | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 1.1.1.22 , oxidoreductase | |
| Response type | Dehydration, oxidation | |
| Substrate | UDP-glucose + 2NAD + + H 2 O | |
| Products | UDP-glucuronate + 2NADH + 2H + | |
| Occurrence | ||
| Homology family | Nucleotide sugar dehydrogenases | |
| Parent taxon | Creature | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 7358 | 22235 |
| Ensemble | ENSG00000109814 | ENSMUSG00000029201 |
| UniProt | O60701 | O70475 |
| Refseq (mRNA) | NM_001184700 | NM_009466 |
| Refseq (protein) | NP_001171629 | NP_033492 |
| Gene locus | Chr 4: 39.5 - 39.53 Mb | Chr 5: 65.41 - 65.44 Mb |
| PubMed search | 7358 |
22235
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The UDP-glucose 6-dehydrogenase (UDPGDH) is the enzyme that in all living things, the conversion of UDP-glucose to UDP-glucuronate catalyzed . The latter is important for biotransformation in the human body , but also serves as the starting material for the synthesis of glycosaminoglycans . In plants, the reaction is an intermediate step in the biosynthesis of hemicellulose and pectin .
Catalyzed reaction
+ 2NAD + + H 2 O ⇔
⇔ 
+ 2NADH + 2H +
UDP-α- D -glucuronate arises from UDP-α- D -glucose. It is noteworthy that no aldehyde is formed when converting alcohol to carboxylic acid .
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Uronic Acid Metabolism - Learning and Teaching Materials
- D'Eustachio / reactome: UDP-glucose is oxidized to UDP-glucuronate