Uroporphyrinogen III synthase

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Uroporphyrinogen III synthase
Uroporphyrinogen III synthase
Uroporphyrinogen III synthase monomer, Thermus thermophilus

Existing structural data : 1jr2

Properties of human protein
Mass / length primary structure 265 amino acids
Secondary to quaternary structure Monomer
Identifier
Gene name UROS
External IDs
Enzyme classification
EC, category 4.2.1.75 lyase
Response type Ring closure, rearrangement
Substrate Hydroxymethylbilane
Products Uroporphyrinogen III + H 2 O
Occurrence
Parent taxon Creature
Orthologue
human House mouse
Entrez 7390 22276
Ensemble ENSG00000188690; ENSMUSG00000030979
UniProt P10746 P51163
Refseq (mRNA) NM_000375 NM_001302085
Refseq (protein) NP_000366 NP_001289014
Gene locus Chr 10: 125.78 - 125.82 Mb Chr 7: 133.69 - 133.71 Mb
PubMed search 7390 22276

The uroporphyrinogen III synthase (URO3S) is the enzyme in animals that the ring closure of hydroxymethylbilane to Uroporphyrinogen III catalyzes a step in the part Porphyrinbiosynthese . URO3S is found in all tissue types in humans. Mutations in the UROS - gene can URO3S deficiency and this to Günther's disease lead.

Catalyzed reaction

HydroxymethylbilaneUroporphyrinogen III

Hydroxymethylbilane cyclizes to uroporphyrinogen III.

Individual evidence

  1. Homologues at OMA
  2. UniProt P10746

Web links