Uroporphyrinogen III synthase
Uroporphyrinogen III synthase | ||
---|---|---|
Uroporphyrinogen III synthase monomer, Thermus thermophilus | ||
Properties of human protein | ||
Mass / length primary structure | 265 amino acids | |
Secondary to quaternary structure | Monomer | |
Identifier | ||
Gene name | UROS | |
External IDs | ||
Enzyme classification | ||
EC, category | 4.2.1.75 , lyase | |
Response type | Ring closure, rearrangement | |
Substrate | Hydroxymethylbilane | |
Products | Uroporphyrinogen III + H 2 O | |
Occurrence | ||
Parent taxon | Creature | |
Orthologue | ||
human | House mouse | |
Entrez | 7390 | 22276 |
Ensemble | ENSG00000188690; | ENSMUSG00000030979 |
UniProt | P10746 | P51163 |
Refseq (mRNA) | NM_000375 | NM_001302085 |
Refseq (protein) | NP_000366 | NP_001289014 |
Gene locus | Chr 10: 125.78 - 125.82 Mb | Chr 7: 133.69 - 133.71 Mb |
PubMed search | 7390 |
22276
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The uroporphyrinogen III synthase (URO3S) is the enzyme in animals that the ring closure of hydroxymethylbilane to Uroporphyrinogen III catalyzes a step in the part Porphyrinbiosynthese . URO3S is found in all tissue types in humans. Mutations in the UROS - gene can URO3S deficiency and this to Günther's disease lead.
Catalyzed reaction
Hydroxymethylbilane cyclizes to uroporphyrinogen III.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Porphyrin Biosynthesis - Learning and Teaching Materials
- Jassal, D'Eustachio / reactome: Conversion of HMB to uroporphyrinogen III