Urs Jenal

from Wikipedia, the free encyclopedia
Urs Jenal, 2010

Urs Jenal (born December 31, 1961 in Alvaneu ) is a Swiss microbiologist and researches at the Biozentrum of the University of Basel .

Life

Urs Jenal studied experimental biology at the ETH Zurich and received his doctorate there in 1991. He then completed postdoctoral degrees at the ETH Zurich and Stanford University . Jenal has been researching and teaching at the Biozentrum of the University of Basel since 1996, initially as an assistant professor and since 2002 as a professor of molecular microbiology.

Act

Urs Jenal researches the molecular basis of signal transmission , which controls the growth , development and behavior of bacteria . Jenal attracted international attention for its discovery of a new signaling pathway based on a new cyclic di-nucleotide (c-di-GMP), which coordinates the formation of microbial biofilms and contributes to the development of chronic bacterial infections . Using the model bacterium Caulobacter crescentus , he discovered that c-di-GMP controls the transition from freely moving bacteria to the sedentary biofilm-forming form and coordinates this process with the reproduction cycle of the cells. Recent work examining the significance of c-di-GMP signaling network for chronic pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis (cystic fibrosis).

Awards

List of publications

  • with S. Steiner, C. Lori and A. Boehm: Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction. In: EMBO J. 32 (3), 2013, pp. 354-368. PMID 23202856
  • with JG Malone, T. Jaeger, P. Manfredi, A. Dötsch, A. Blanka, R. Bos, GR Cornelis and S. Häussler: The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways . In: PLoS Pathogens. 8 (6), 2012, p. E1002760. PMID 22719254
  • with S. Abel, P. Chien, P. Wassmann, T. Schirmer, V. Kaever, MT Laub and TA Baker: Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks. In: Mol Cell. 43, 2011, pp. 550-560. (IF: 14.447)
  • with JG Malone, T. Jaeger, C. Spangler, D. Ritz, A. Spang, C. Arrieumerlou, V. Kaever and R. Landmann: YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa. In: PLoS Pathogens. 6 (3), 2010, p. E1000804.
  • with A. Boehm, M. Kaiser, H. Li, C. Spangler, CA Kasper, M. Ackermann, V. Kaever, V. Sourjik and V. Roth: Second messenger mediated adjustment of bacterial swimming velocity. In: Cell. 141, 2010, p. 107.
  • with A. Duerig, S. Abel, M. Folcher, M. Nicollier, T. Schwede, N. Amiot and B. Giese: Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression. In: Genes and Development. 23 (1), 2009, p. 93.
  • with T. Schirmer: Structural and mechanistic determinants of c-di-GMP signaling. In: Nature Rev Microbiol. 7, 2009, pp. 724-735. PMID 19756011
  • with A. Boehm, S. Steiner, F. Zaehringer, A. Casanova, F. Hamburger, D. Ritz, W. Keck, M. Ackermann and T. Schirmer: Second messenger signaling governs Escherichia coli biofilm induction upon ribosomal stress. In: Mol Microbiol. 72 (6), 2009, pp. 1500-1516. PMID 19460094
  • with R. Paul, T. Jaeger, S. Abel, I. Wiederkehr, M. Folcher, EG Biondi and MT Laub: Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate. In: Cell. 133 (3), 2008, p. 452.
  • with M. Christen, B. Christen, MG Allan, M. Folcher, P. Jeno and S. Grzesiek: DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus. In: Proc Natl Acad Sci US A. 104, 2007, p. 4112.
  • with B. Christen, M. Christen, R. Paul, F. Schmid, M. Folcher, P. Jenoe and M. Meuwly: Allosteric control of cyclic di-GMP signaling. In: Journal Biological Chemistry. 281, 2006, p. 32015.
  • with J. Malone: Mechanisms of cyclic-di-GMP signaling in bacteria. In: Annual Review of Genetics. 40, 2006, p. 385.
  • with M. Christen, B. Christen, M. Folcher and A. Schauerte: Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP. In: Journal Biological Chemistry. 280, 2005, p. 30829.
  • with R. Paul, S. Weiser, NC Amiot, C. Chan, T. Schirmer and B. Giese: Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. In: Genes and Development. 18 (6), 2004, p. 715.
  • with M. Ackermann and SC Stearns: Senescence in a bacterium with asymmetric division. In: Science. 300 (5627), 2003, p. 1920.

Web links

Individual evidence

  1. ↑ Curriculum Vitae
  2. ^ Research group
  3. ↑ American Academy of Microbiology (AAM), Fellows Elected in 2011 ( Memento of the original from July 24, 2013 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / academy.asm.org
  4. ^ European Molecular Biology Organization Membership
  5. ↑ List of publications
personal data
SURNAME Jenal, Urs
BRIEF DESCRIPTION Swiss microbiologist and professor at the Biozentrum of the University of Basel, Switzerland
DATE OF BIRTH December 31, 1961
PLACE OF BIRTH Alvaneu