Verrucarin A

Structural formula
General
Surname	Verrucarin A
other names	Muconomycin A
Molecular formula	C 27 H 34 O 9
Brief description	colorless powder
External identifiers / databases
CAS number 3148-09-2 EC number 636-535-7 ECHA InfoCard 100.164.324 PubChem 6326658 Wikidata Q1586727
properties
Molar mass	502.55 g mol −1
Physical state	firmly
safety instructions
GHS labeling of hazardous substances danger H and P phrases H: 300-310-330 P: 260-264-280-284-302 + 350-310
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Verrucarin A is a mycotoxin (mold toxin) from the group of macrocyclic trichothecenes . It arises as a metabolic product of the fungus Myrothecium roridum .

Extraction and presentation

Verrucarin A can be obtained from anguidine , propargyl alcohol and furfural .

use

Verrucarin A and also Verrucarin J are being investigated not only for the growth inhibition of the androgen-dependent prostate cancer cells LNCaP, but also for the growth inhibition of the androgen-independent prostate cancer cells DU-145.

Related links

There are several variants of the toxin from A to J.

Individual evidence

1. ↑ ^{a b c} data sheet Verrucarin A from Myrothecium sp. at Sigma-Aldrich , accessed on April 25, 2011 ( PDF ).
2. ↑ W. Clark Still, Hiroshi Ohmizu: Synthesis of verrucarin A. In: J. Org. Chem., 1981, 46 (25), pp 5242-5244 doi : 10.1021 / jo00338a046 .
3. ↑ Compounds from Myrothecium Sp. To inhibit cancer cell growth (patent DE) (PDF; 237 kB).