Wolfgang Holtmeier

Wolfgang Holtmeier (born March 16, 1965 in Freiburg im Breisgau ) is a German internist , gastroenterologist , endocrinologist and diabetologist at the Porz am Rhein hospital . Holtmeier is a specialist in the field of celiac disease , food intolerance ( wheat sensitivity ) and chronic inflammatory bowel diseases .

Life

Holtmeier studied human medicine in Freiburg and Hamburg and received his doctorate in neuroradiology at the University of Hamburg in 1992 . From 1992 to 1995 he conducted research in the laboratory ("Mucosal Immunology") of Martin F. Kagnoff at the University of California at San Diego (USA) on celiac disease and inflammatory bowel disease (IBD). He received his gastroenterological training from Wolfgang F. Caspary at the University of Frankfurt . Holtmeier completed his habilitation in 2003 and worked until 2007 as a senior physician at Medical Clinic I in Frankfurt. In 2003 he was qualified as a specialist immunologist by the German Society for Immunology , in 2004 the specialization in gastroenterology and in 2007 the specialization in diabetology and endocrinology. Since 2008 Holtmeier has been the chief physician of the clinic for internal medicine, gastroenterology and diabetology at the Porz am Rhein Hospital (academic teaching hospital of the University of Cologne ). In 2011 he was awarded an “extraordinary professor” from the University of Cologne.

Scientific contribution

From 1992 to 1995 Holtmeier conducted research in the Laboratory of Mucosal Immunology in San Diego , USA (Head: MF Kagnoff) on the barrier function of the immune system in the intestinal mucosa . This research could later be continued at the University of Frankfurt with the help of the German Research Foundation . The focus was on the characterization of the antigen-specific receptors of γ / δ T cells . Here Holtmeier was able to show that the δ T-cell receptor repertoire in adults has a limited variety both in the blood and in the large and small intestines. In addition, it was compartmentalized in various organs and remained unchanged over time. Similar findings could also be demonstrated in pigs. The IgA antibodies produced by B cells also showed limited diversity in the intestine. Thus, both γ / δ T cells and IgA B cells of the intestinal mucosa presumably recognize conserved antigens. In the course of his clinical career, Holtmeier was also involved in the therapy of inflammatory bowel disease and led a study in which an incense extract was investigated to maintain remission in patients with Crohn's disease. He has also been working in the field of celiac disease and wheat sensitivity for many years .

Holtmeier is also active as a reviewer in the following scientific journals: "Gastroenterology", " Gut ", " American Journal of Physiology ", "Journal of Immunology" and "Immunology".

Memberships in scientific associations (selection)

Holtmeier is a member of the Scientific Advisory Board of the German Celiac Society (DZG) , the Medical Advisory Board of the German Crohn and Colitis Association (DCCV) and the Walter Siegenthaler Society for Advances in Internal Medicine as well as a Fellow of the European Board of Gastroenterology (FEBG).

honors and awards

1992 Two-year USA scholarship from the German National Academic Foundation ( BASF research program).
1995 Scholarship from the Crohn and Colitis Foundation of America (CCFA)
1998-2006 Continuous conveying of various research projects in the area of mucosa -Immunology (γ / δ T cell research in IBD and celiac disease) by the German Research Foundation
1997 Funding of a research project (celiac disease and dermatitis herpetiformis) by the Paul and Ursula Klein Foundation, Frankfurt am Main and the German Celiac Society, Stuttgart
1998 Novartis Foundation graduate fellowship for therapeutic research
2000 Research Promotion Prize, Dr. August Scheidel Foundation, Frankfurt
2000 Scientific award from the Rhein-Main working group for gastroenterology
2001 Research Promotion Prize from the Fritz Riese Foundation, Frankfurt am Main

Publications

Publication list PubMed

Web links

"Weizenwampe" - a book that leads astray, interview with Wolfgang Holtmeier (Mehlreport, January 2013)
Interview "Always exclude celiac disease first" (Lioba Lepping, Kölner Stadt-Anzeiger, June 22, 2014)
Does wheat make you sick? (ARD W-wie-Wissen)
Causes of gluten intolerance (3sat, Nano)
Celiac Disease - Gluten Intolerance: What is it? (YouTube)
Celiac disease, at home and on the go, WDR (YouTube)
Crohn's disease and ulcerative colitis, at home and on the go, WDR (YouTube)
Stern-TV with Günther Jauch: Celiac Disease, RTL Part 1 , Part 2

Individual evidence

↑ ^a ^b Clinic for Gastroenterology, Diabetology and Internal Medicine, Porz am Rhein Hospital
^ Hospital Porz am Rhein, Curriculum Vitae Wolfgang Holtmeier
↑ Chowers, Y., Holtmeier, W., Harwood, J., Morzycka-Wroblewska, E. and Kagnoff, MF The Vδ1 T cell receptor repertoire in human small intestine and colon. J. Exp. Med. 180: 183-190, 1994.
↑ Holtmeier, W., Chowers, Y., Lumeng, A., Morzycka-Wroblewska, E. and Kagnoff, MF The δ T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V-Region usage. J. Clin. Invest. 96: 1108-1117, 1995.
↑ Holtmeier, W., Witthöft, T., Hennemann, A., Winter, HS and Kagnoff, MF The TCR δ repertoire in human intestine undergoes characteristic changes during fetal to adult development. J. Immunology. 158: 5632-5641, 1997.
↑ Holtmeier, W., Käller, J., Geisel, W., Pabst, R., Caspary, WF and Rothkötter, HJ Development and compartmentalization of the porcine TCR δ repertoire at mucosal and extraintestinal sites. The pig as a model for analyzing the effects of age and microbial factors. J Immunology, 169: 1993-2002, 2002.
↑ Holtmeier, W., Hennemann, A. and Caspary, WF IgA and IgM VH repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated. Gastroenterology 119: 1253-1266, 2000.
↑ Holtmeier W. The γ / δ T cell bridge: Linking innate and acquired immunity in: Mechanisms of intestinal inflammation. Implications for therapeutic intervention in IBD, edited by Zeitz M. et al. Dordrecht: Kluwer Academic Publishers, 2004, 16-27.
↑ Holtmeier W., Zeuzem S., Preiß J., Kruis W., Böhm S., Maaser C., Raedler A., Schmidt C., Schnitker J., Schwarz JA, Zeitz M. and Caspary WF A randomized, placebo -controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohns disease: good safety profile but lack of efficacy. Inflamm Bowel Dis; 17: 573-582, 2011.
^ Stein J. Sprue / Celiac disease in: Diseases of the small and large intestine, edited by Caspary WF, Stein J. Heidelberg: Springer-Verlag, 1999, 283-294
↑ W. Holtmeier. Microbiome and Celiac Disease in the “Microbiome” manual. Editors: A. Stallmach and M. Vehreschild; Walter de Gruyter Verlag Berlin / Boston, 2016, 139-148.
↑ Catassi, Carlo, Julio C. Bai, Bruno Bonaz, Gerd Bouma, Antonio Calabrò, Antonio Carroccio, Gemma Castillejo, et al. "Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders." Nutrients 5, no. 10 (September 26, 2013): 3839-53. doi: 10.3390 / nu5103839 .

personal data
SURNAME	Holtmeier, Wolfgang
BRIEF DESCRIPTION	German internist
DATE OF BIRTH	March 16, 1965
PLACE OF BIRTH	Freiburg in Breisgau

[b-1] Clinic for Gastroenterology, Diabetology and Internal Medicine, Porz am Rhein Hospital

[a-2] Hospital Porz am Rhein, Curriculum Vitae Wolfgang Holtmeier

[3] Chowers, Y., Holtmeier, W., Harwood, J., Morzycka-Wroblewska, E. and Kagnoff, MF The Vδ1 T cell receptor repertoire in human small intestine and colon. J. Exp. Med. 180: 183-190, 1994.

[4] Holtmeier, W., Chowers, Y., Lumeng, A., Morzycka-Wroblewska, E. and Kagnoff, MF The δ T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V-Region usage. J. Clin. Invest. 96: 1108-1117, 1995.

[5] Holtmeier, W., Witthöft, T., Hennemann, A., Winter, HS and Kagnoff, MF The TCR δ repertoire in human intestine undergoes characteristic changes during fetal to adult development. J. Immunology. 158: 5632-5641, 1997.

[6] Holtmeier, W., Käller, J., Geisel, W., Pabst, R., Caspary, WF and Rothkötter, HJ Development and compartmentalization of the porcine TCR δ repertoire at mucosal and extraintestinal sites. The pig as a model for analyzing the effects of age and microbial factors. J Immunology, 169: 1993-2002, 2002.

[7] Holtmeier, W., Hennemann, A. and Caspary, WF IgA and IgM VH repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated. Gastroenterology 119: 1253-1266, 2000.

[8] Holtmeier W. The γ / δ T cell bridge: Linking innate and acquired immunity in: Mechanisms of intestinal inflammation. Implications for therapeutic intervention in IBD, edited by Zeitz M. et al. Dordrecht: Kluwer Academic Publishers, 2004, 16-27.

[9] Holtmeier W., Zeuzem S., Preiß J., Kruis W., Böhm S., Maaser C., Raedler A., Schmidt C., Schnitker J., Schwarz JA, Zeitz M. and Caspary WF A randomized, placebo -controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohns disease: good safety profile but lack of efficacy. Inflamm Bowel Dis; 17: 573-582, 2011.

[10] Stein J. Sprue / Celiac disease in: Diseases of the small and large intestine, edited by Caspary WF, Stein J. Heidelberg: Springer-Verlag, 1999, 283-294

[11] W. Holtmeier. Microbiome and Celiac Disease in the “Microbiome” manual. Editors: A. Stallmach and M. Vehreschild; Walter de Gruyter Verlag Berlin / Boston, 2016, 139-148.

[12] Catassi, Carlo, Julio C. Bai, Bruno Bonaz, Gerd Bouma, Antonio Calabrò, Antonio Carroccio, Gemma Castillejo, et al. "Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders." Nutrients 5, no. 10 (September 26, 2013): 3839-53. doi: 10.3390 / nu5103839 .