Wolfgang Schamel

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Wolfgang Werner August Schamel (born June 7, 1968 in Bayreuth ) is a German immunologist and professor of immunology at the Faculty of Biology at the Albert Ludwig University of Freiburg and at the Center for Chronic Immunodeficiency in Freiburg.

Life

Wolfgang Schamel went to school in Los Angeles, Munich and Bochum and graduated from the Hildegardis School in Bochum in 1987 . From 1988 he studied biochemistry at the Free University of Berlin . Research stays took him to Indonesia, England, Israel and the USA. He completed his diploma thesis in 1994 with Yosef Yarden at the Weizmann Institute in Rehovot, Israel. He then began his dissertation with Michael Reth at the Max Planck Institute for Immunobiology, Freiburg, which he completed in 1999. After two years of postdoctoral work with Balbino Alarcón at the “Centro de Biología Molecular Severo Ochoa” in Madrid , he returned to the Max Planck Institute for Immunobiology, where he became Emmy Noether group leader in 2002 . In August 2010 he followed a call to the Faculty of Biology at the Albert-Ludwigs-Universität Freiburg and the Center for Chronic Immunodeficiency in Freiburg and became Professor of Immunology.

He is the coordinator of the EU consortium SYBILLA and a member of the management committee of the Spemann Graduate School for Biology and Medicine (SGBM) at the Albert-Ludwigs-Universität Freiburg . In addition, he is project leader in the Collaborative Research Center 620 (SFB620) and in the Cluster of Excellence “Center for Biological Signaling Studies” (BIOSS) of the German Research Foundation .

Wolfgang Schamel has been married to the Spanish teacher Maria del Prado Garcia Lopez since 1996. The couple has a son.

research

Wolfgang Schamel uses biochemical and proteomic methods to elucidate the molecular mechanisms of the immune system in humans and mice. He is particularly interested in the activation of T cells , which play an important role in specific immunity . He has published important work on the function of the T cell receptor , such as B. the permissive geometry model. Another research focus is the intracellular signal transduction network of T cells.

Primary literature

  • S. Minguet, M. Swamy, B. Alarcón, IF Luescher, WW Schamel: Full activation of the T cell receptor requires both clustering and conformational changes at CD3. In: Immunity . 26, 2007, pp. 43-54. Online (in English, accessed on November 15, 2010)
  • GM Siegers, M. Swamy, E. Fernández-Malavé, S. Minguet, S. Rathmann, AC Guardo, V. Pérez-Flores, JR Regueiro, B. Alarcón, P. Fisch, WW Schamel: Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies. In: Journal of Experimental Medicine . 204, 2007, pp. 2537-2544.
  • AG Schrum, D. Gil, EP Dopfer, DL Wiest, LA Turka, WW Schamel, E. Palmer: High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. In: Science . STKE 389, 2007, p. Pl2.
  • WW Schamel, I. Arechaga, RM Risueño, HM van Santen, P. Cabezas, C. Risco, JM Valpuesta, B. Alarcón: Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. In: Journal of Experimental Medicine. 202, 2005, pp. 493-503.
  • MM Camacho-Carvajal, B. Wollscheid, R. Aebersold, V. Steimle, WW Schamel: Two-dimensional Blue native / SDS gel electrophoresis of multi-protein complexes from whole cellular lysates: a proteomics approach. In: Molecular and Cellular Proteomics. 3, 2004, pp. 176-182.
  • D. Gil, WW Schamel, M. Montoya, F. Sánchez-Madrid, B. Alarcón: Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. In: Cell . 109, 2002, pp. 901-912.
  • WW Schamel, M. Reth: Monomeric and oligomeric complexes of the B cell antigen receptor. In: Immunity. 13, 2000, pp. 5-14.
  • Wolfgang WA Schamel: Functional and structural characterization of membrane bound immunoglobulin (mIg) complexes . Dissertation. 1999, p. 153 .

Secondary literature

  • Anja Possart: Clustering versus oligomerization. In: Laborjournal. 5, 2007, pp. 30-31.
  • Heather L. Van Epps: TCR chain gangs. In: The Journal of Experimental Medicine. 202, 2005, pp. 458-458.
  • Michael S. Hershfield: New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency. In: European Journal of Immunology. 35, 2005, pp. 25-30. doi : 10.1002 / eji.200425524
  • Mark M. Davis: A New Trigger for T Cells. In: Cell. 110, 2002, pp. 285-287.

Review article

  • E. Molnár, EP Dopfer, S. Deswal, WW Schamel: Models of antigen receptor activation in the design of vaccines. In: Current Pharmaceutical Design 15, 2009, pp. 3237-3248.
  • S. Minguet, WW Schamel: A permissive geometry model for TCR-CD3 activation. In: Trends in Biochemical Sciences . 33, 2008, pp. 51-57. doi: 10.1016 / j.tibs.2007.10.008 (English)
  • B. Alarcón, M. Swamy, HM van Santen, WW Schamel: T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity. In: EMBO Reports. 7, 2006, pp. 490-495. EMBO Reports (in English, accessed on November 15, 2010)
  • WW Schamel, RM Risueño, S. Minguet, AR Ortíz, B. Alarcón: A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex. In: Trends in Immunology 27, 2006, pp. 176-182.

Awards

  • Acris Award from the Society for Signal Transduction, 2005.
  • Hans Spemann Prize from the University of Freiburg, 2000

Individual evidence

  1. ^ Albrecht-Ludwigs-Universität: CV of Wolfgang Schamel . Retrieved November 26, 2013.
  2. ↑ DFG GEPRIS (requested on November 15, 2010)
  3. ↑ Center for Chronic Immunodeficiency (in English, accessed on November 16, 2010)
  4. ↑ EU consortium SYBILLA (queried on November 16, 2010)
  5. ↑ Spemann Graduate School for Biology and Medicine (SGBM) (in English, requested on November 16, 2010)
  6. ↑ Collaborative Research Center 620 ( Memento from July 30, 2011 in the Internet Archive ) (accessed on November 16, 2010)
  7. ↑ Cluster of Excellence BIOSS ( Memento from December 3, 2013 in the Internet Archive ) (in English, accessed on November 16, 2010)
  8. ^ Hans Spemann Prize. on the website of the University of Freiburg. (queried on November 15, 2010)
personal data
SURNAME Schamel, Wolfgang
ALTERNATIVE NAMES Schamel, Wolfgang Werner August (full name)
BRIEF DESCRIPTION German immunologist
DATE OF BIRTH 7th June 1968
PLACE OF BIRTH Bayreuth