Yvette van Kooyk

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Yvette van Kooyk (2019)

Yvette van Kooyk (born August 13, 1961 in Amsterdam ) is a Dutch cell biologist and immunologist. She is a pioneer in glycoimmunology.

Yvette van Kooyk received her degree in medical biology from the University of Amsterdam in 1988 , where she received her PhD in 1993. The dissertation was done in the Immunology Department of the Dutch Cancer Institute in Amsterdam and dealt with the adhesion of lymphocytes with integrin . As a post-doctoral student , she was in Carl Figdor's tumor immunology group at the University Hospital of Radboud University Nijmegen . There she researched the activation of integrin and the adhesion mechanisms of dendritic cells (DC) of the immune system. In 2000 she received an Aspasia scholarship after her discovery of the receptor in the innate immune system DC-SIGN. She also discovered the receptor L-SIGN, which also works by binding sugar molecules. Also in 2000 she published her discovery that DC-SIGN is a receptor for HIV that deceives the immune system and is involved in the sexual spread of the disease. She also became an assistant professor in Nijmegen.

In 2001 she moved to the Medical Center of the Free University of Amsterdam , where she became Professor of Molecular Cell Biology and headed a research group on dendritic cells. In addition, with the 2001 Pioneer grant from the NWO, she began to research the role of sugars attached to proteins in immunology (communication of immune cells) and especially in dendritic cells (functional glycomics ). She succeeded in discovering further interactions of pathogens via lectin receptors of type C (DC-Sign, L-Sign) on dendritic cells. Yvette van Kooyk heads the Department of Molecular Cell Biology and Immunology at the Medical Center of the Free University of Amsterdam.

She works on diagnostic and therapeutic methods based on glycans on dendritic cells, for example in cancer and autoimmune diseases (allergies), especially sugars, which suppress the immune system. To this end, she founded the startup DC4U in 2006.

Her film Glycotreat for the treatment of cancer received the prize for international scientific short film at the Cannes Film Festival in 2018.

For 2019 she received the Spinoza Prize . She also received the van Loghem Prize in 2014, a TOP Grant from the NWO in 2015 and an ERC Advanced Grant in 2013. She has been a member of the Royal Netherlands Academy of Sciences (KNAW) since 2017.

Web links

Individual evidence

  1. ↑ Carl Figdor, Yvette van Kooyk and a .: Identification of DC-SIGN, a Novel Dendritic Cell-Specific ICAM-3 Receptor that Supports Primary Immune Responses, Cell , Volume 100, March 2000, P575-585
  2. ↑ Figdor, van Kooyk et al. a .: DC-SIGN, a dendritic cell-specific HIV-1 binding protein that enhances trans-infection of T cells, Cell , Volume 100, 2000, pp. 587-597.
  3. ↑ Spinoza Prize 2019 for van Kooyk , NWO
personal data
SURNAME Kooyk, Yvette van
BRIEF DESCRIPTION Dutch cell biologist and immunologist
DATE OF BIRTH August 13, 1961
PLACE OF BIRTH Amsterdam