Infectious hematopoietic necrosis virus: Difference between revisions

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{{Short description|Species of virus}}
{{Taxobox
{{Virusbox
⚫
| name = infectious hematopoietic necrosis virus (IHNV)
⚫
| parent = Novirhabdovirus
| virus_group = v
⚫
| species = Salmonid novirhabdovirus
| ordo = ''[[Mononegavirales]]''
⚫
| synonyms = * Infectious hematopoietic necrosis virus
| familia = ''[[Rhabdoviridae]]''
⚫
| genus = ''[[Novirhabdovirus]]''
⚫
| species = '''''Oncorhynchus 1 novirhabdovirus'''''
}}
}}
'''Infectious hematopoietic necrosis virus''' (IHNV), is a negative-sense single-stranded, bullet-shaped [[RNA]] [[virus]] that is a member of the ''[[Rhabdoviridae]]'' family, and from the [[genus]] ''[[Novirhabdovirus]]''. It causes the disease known as infectious hematopoietic necrosis in [[salmonid]] [[fish]] such as [[trout]] and [[salmon]]. The disease may be referred to by a number of other names such as Chinook salmon disease, Coleman disease, Columbia River sockeye disease, Cultus Lake virus disease, Oregon sockeye disease, Sacramento River Chinook disease and sockeye salmon viral disease. IHNV is commonly found in the [[Pacific Coast]] of Canada and the United States, and has also been found in [[Europe]] and Japan.<ref>{{ cite journal |author1=Rudakova, S. L. |author2=Kurath, G. |author3=Bochkova, E. V. | title = Occurrence and Genetic Typing of Infectious Hematopoietic Necrosis Virus in Kamchatka, Russia | journal = Diseases of Aquatic Organisms | volume = 75 | issue = 1 | pages = 1–11 |date=March 2007 | pmid = 17523538 | doi = 10.3354/dao075001 }}</ref><ref name="Nishizawa2006">{{ cite journal |author1=Nishizawa, T. |author2=Kinoshita, S. |author3=Kim, W. S. |author4=Higashi, S. |author5=Yoshimizu, M. | title = Nucleotide Diversity of Japanese Isolates of Infectious Hematopoietic Necrosis Virus (IHNV) Based on the Glycoprotein Gene | journal = Diseases of Aquatic Organisms | volume = 71 | issue = 3 | pages = 267–272 |date=August 2006 | pmid = 17058607 | doi = 10.3354/dao071267 }}</ref><ref>{{ cite journal |author1=Enzmann, P. J. |author2=Kurath, G. |author3=Fichtner, D. |author4=Bergmann, S. M. | title = Infectious Hematopoietic Necrosis Virus: Monophyletic Origin of European Isolates from North American Genogroup M | journal = Diseases of Aquatic Organisms | volume = 66 | issue = 3 | pages = 187–195 |date=September 2005 | pmid = 16261933 | doi = 10.3354/dao066187 }}</ref> The first reported epidemics of IHNV occurred in the United States at the Washington and the Oregon fish hatcheries during the 1950s.<ref>{{ cite journal |author1=Rucker, R. R. |author2=Whipple, W. J. |author3=Parvin, J. R. |author4=Evans, C. A. | year = 1953 | title = A Contagious Disease of Salmon Possibly of Virus Origin | publisher = United States Fish and Wildlife Service | journal = Fishery Bulletin | volume = 76 | pages = 35–46 }}</ref>
'''Infectious hematopoietic necrosis virus''' (IHNV), is a negative-sense single-stranded, bullet-shaped [[RNA]] [[virus]] that is a member of the ''[[Rhabdoviridae]]'' family, and from the [[genus]] ''[[Novirhabdovirus]]''. It causes the disease known as infectious hematopoietic necrosis in [[salmonid]] [[fish]] such as [[trout]] and [[salmon]]. The disease may be referred to by a number of other names such as Chinook salmon disease, Coleman disease, Columbia River sockeye disease, Cultus Lake virus disease, Oregon sockeye disease, Sacramento River Chinook disease and sockeye salmon viral disease. IHNV is commonly found in the [[Pacific Coast]] of Canada and the United States, and has also been found in [[Europe]] and Japan.<ref>{{ cite journal |author1=Rudakova, S. L. |author2=Kurath, G. |author3=Bochkova, E. V. | title = Occurrence and Genetic Typing of Infectious Hematopoietic Necrosis Virus in Kamchatka, Russia | journal = Diseases of Aquatic Organisms | volume = 75 | issue = 1 | pages = 1–11 |date=March 2007 | pmid = 17523538 | doi = 10.3354/dao075001 | doi-access = free }}</ref><ref name="Nishizawa2006">{{ cite journal |author1=Nishizawa, T. |author2=Kinoshita, S. |author3=Kim, W. S. |author4=Higashi, S. |author5=Yoshimizu, M. | title = Nucleotide Diversity of Japanese Isolates of Infectious Hematopoietic Necrosis Virus (IHNV) Based on the Glycoprotein Gene | journal = Diseases of Aquatic Organisms | volume = 71 | issue = 3 | pages = 267–272 |date=August 2006 | pmid = 17058607 | doi = 10.3354/dao071267 |hdl=2115/43977 |doi-access=free |hdl-access=free }}</ref><ref>{{ cite journal |author1=Enzmann, P. J. |author2=Kurath, G. |author3=Fichtner, D. |author4=Bergmann, S. M. | title = Infectious Hematopoietic Necrosis Virus: Monophyletic Origin of European Isolates from North American Genogroup M | journal = Diseases of Aquatic Organisms | volume = 66 | issue = 3 | pages = 187–195 |date=September 2005 | pmid = 16261933 | doi = 10.3354/dao066187 | doi-access = free }}</ref> The first reported epidemics of IHNV occurred in the United States at the Washington and the Oregon fish hatcheries during the 1950s.<ref>{{ cite journal |author1=Rucker, R. R. |author2=Whipple, W. J. |author3=Parvin, J. R. |author4=Evans, C. A. | year = 1953 | title = A Contagious Disease of Salmon Possibly of Virus Origin | journal = Fishery Bulletin | volume = 76 | pages = 35–46 }}</ref>
IHNV is [[Horizontal transmission|transmitted]] following [[viral shedding|shedding of the virus]] in the [[feces]], [[urine]], sexual fluids, and external [[mucus]] and by direct contact or close contact with surrounding water. The virus gains entry into fish at the base of the [[fin]]s.<ref>{{ cite journal |author1=Harmache, A. |author2=LeBerre, M. |author3=Droineau, S. |author4=Giovannini, M. |author5=Brémont, M. | title = Bioluminescence Imaging of Live Infected Salmonids Reveals that the Fin Bases are the Major Portal of Entry for ''Novirhabdovirus'' | journal = Journal of Virology | volume = 80 | issue = 7 | pages = 3655–3659 |date=April 2006 | pmid = 16537634 | pmc = 1440417 | doi = 10.1128/JVI.80.7.3655-3659.2006 }}</ref>
IHNV is [[Horizontal transmission|transmitted]] following [[viral shedding|shedding of the virus]] in the [[feces]], [[urine]], sexual fluids, and external [[mucus]] and by direct contact or close contact with the surrounding water. The virus gains entry into fish at the base of the [[fin]]s.<ref>{{ cite journal |author1=Harmache, A. |author2=LeBerre, M. |author3=Droineau, S. |author4=Giovannini, M. |author5=Brémont, M. | title = Bioluminescence Imaging of Live Infected Salmonids Reveals that the Fin Bases are the Major Portal of Entry for ''Novirhabdovirus'' | journal = Journal of Virology | volume = 80 | issue = 7 | pages = 3655–3659 |date=April 2006 | pmid = 16537634 | pmc = 1440417 | doi = 10.1128/JVI.80.7.3655-3659.2006 }}</ref>


The disease is listed as a nonexotic disease of the [[European Union|EU]] and is therefore watched closely by the [[European Community Reference Laboratory for Fish Diseases]]. To keep track of the distribution of different IHNV genotypes, a database called [[Fishpathogens.eu]]<ref>{{ cite web | url = http://www.fishpathogens.eu | title = Fishpathogens.eu Database | publisher = Epizone - European Community Reference Laboratory for Fish Diseases }}</ref> has been created to store data on different [[fish]] pathogens (including IHNV) and their sequences.
The disease is listed as a nonexotic disease of the [[European Union|EU]] and is therefore watched closely by the [[European Community Reference Laboratory for Fish Diseases]]. To keep track of the distribution of different IHNV genotypes, a database called [[Fishpathogens.eu]]<ref>{{ cite web | url = http://www.fishpathogens.eu | title = Fishpathogens.eu Database | publisher = Epizone - European Community Reference Laboratory for Fish Diseases }}</ref> has been created to store data on different [[fish]] pathogens (including IHNV) and their sequences.


==Classification==
==Classification==
IHNV is the causal agent of infectious hematopoietic necrosis (IHN) disease of fish and is a negative-sense single-stranded RNA virus. IHNV is a member of the [[genus]] ''[[Novirhabdovirus]]'',<ref>{{ cite web | url = https://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/01.062.0.06.001.htm | title = ICTVdB Virus Code: 01.062.0.06.001 | publisher = National Institutes of Health }}</ref> belongs to the family of ''[[Rhabdoviridae]]''. The North American IHNV isolates are grouped based on the partial glycoprotein (G) gene sequences.<ref>{{ cite journal |author1=Kurath, G. |author2=Garver, K. A. |author3=Troyer, R. M. |author4=Emmenegger, E. J. |author5=Einer-Jensen, K. |author6=Anderson, E. D. | title = Phylogeography of Infectious Haematopoietic Necrosis Virus in North America | journal = The Journal of General Virology | volume = 84 | issue = 4 | pages = 803–814 |date=April 2003 | pmid = 12655081 | doi = 10.1099/vir.0.18771-0 }}</ref> The three major IHNV genogroups in North America are designated as U, M, and L for the upper, middle and lower portions of IHNV geographical range in North America. The Japanese and Korean isolates constitute a new Japanese rainbow trout genogroup.<ref name="Nishizawa2006" /><ref>{{ cite journal |author1=Kim, W. S. |author2=Oh, M. J. |author3=Nishizawa, T. |author4=Park, J. W. |author5=Kurath, G. |author6=Yoshimizu, M. | title = Genotyping of Korean Isolates of Infectious Hematopoietic Necrosis Virus (IHNV) Based on the Glycoprotein Gene | journal = Archives of Virology | volume = 152 | issue = 11 | pages = 2119–2124 | year = 2007 | pmid = 17668275 | doi = 10.1007/s00705-007-1027-9 }}</ref>
IHNV is the causal agent of infectious hematopoietic necrosis (IHN) disease of fish and is a negative-sense single-stranded RNA virus. IHNV is a member of the [[genus]] ''[[Novirhabdovirus]]'',<ref>{{ cite web | url = https://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/01.062.0.06.001.htm | title = ICTVdB Virus Code: 01.062.0.06.001 | date = 19 January 2023 | publisher = National Institutes of Health }}</ref> belongs to the family of ''[[Rhabdoviridae]]''. The North American IHNV isolates are grouped based on the partial glycoprotein (G) gene sequences.<ref>{{ cite journal |author1=Kurath, G. |author2=Garver, K. A. |author3=Troyer, R. M. |author4=Emmenegger, E. J. |author5=Einer-Jensen, K. |author6=Anderson, E. D. | title = Phylogeography of Infectious Haematopoietic Necrosis Virus in North America | journal = The Journal of General Virology | volume = 84 | issue = 4 | pages = 803–814 |date=April 2003 | pmid = 12655081 | doi = 10.1099/vir.0.18771-0 |doi-access=free }}</ref> The three major IHNV genogroups in North America are designated as U, M, and L for the upper, middle and lower portions of IHNV geographical range in North America. The Japanese and Korean isolates constitute a new Japanese rainbow trout genogroup.<ref name="Nishizawa2006" /><ref>{{ cite journal |author1=Kim, W. S. |author2=Oh, M. J. |author3=Nishizawa, T. |author4=Park, J. W. |author5=Kurath, G. |author6=Yoshimizu, M. | title = Genotyping of Korean Isolates of Infectious Hematopoietic Necrosis Virus (IHNV) Based on the Glycoprotein Gene | journal = Archives of Virology | volume = 152 | issue = 11 | pages = 2119–2124 | year = 2007 | pmid = 17668275 | doi = 10.1007/s00705-007-1027-9 |hdl=2115/32293 |s2cid=10041775 | hdl-access = free }}</ref>


==Virion==
==Virion==
Virions consist of an envelope and a nucleocapsid. Virions are bullet-shaped and measure 45-100&nbsp;nm in diameter, and 100-430&nbsp;nm in length.<ref>{{ cite journal | last1 = Hill | first1 = B. J. | last2 = Underwood | first2 = B. O. | last3 = Smale | first3 = C. J. | last4 = Brown | first4 = F. | title = Physico-Chemical and Serological Characterization of five Rhabdoviruses Infecting Fish | journal = The Journal of General Virology | volume = 27 | issue = 3 | pages = 369–378 |date=June 1975 | pmid = 1170278 | doi = 10.1099/0022-1317-27-3-369 }}</ref> Surface projections are densely dispersed, distinctive spikes that cover the whole surface except for the quasiplanar end.
Virions consist of an envelope and a nucleocapsid. Virions are bullet-shaped and measure 45-100&nbsp;nm in diameter, and 100-430&nbsp;nm in length.<ref>{{ cite journal | last1 = Hill | first1 = B. J. | last2 = Underwood | first2 = B. O. | last3 = Smale | first3 = C. J. | last4 = Brown | first4 = F. | title = Physico-Chemical and Serological Characterization of five Rhabdoviruses Infecting Fish | journal = The Journal of General Virology | volume = 27 | issue = 3 | pages = 369–378 |date=June 1975 | pmid = 1170278 | doi = 10.1099/0022-1317-27-3-369 | doi-access = free }}</ref> Surface projections are densely dispersed, distinctive spikes that cover the whole surface except for the quasiplanar end.


==Genome organization==
==Genome organization==


The fish rhabdovirus IHNV has a bullet-shaped virion containing an unsegmented, negative-sense, single-stranded RNA genome of about 11,000 nucleotides that encode six proteins in this order: a nucleoprotein (N), a phosphoprotein (P), a matrix protein (M), a glycoprotein (G), a nonvirion protein (NV), and a polymerase (L).<ref>{{ cite journal |author1=Kurath, G. |author2=Leong, J. C. | title = Characterization of Infectious Hematopoietic Necrosis Virus mRNA Species Reveals a Nonvirion Rhabdovirus Protein | journal = Journal of Virology | volume = 53 | issue = 2 | pages = 462–468 |date=February 1985 | pmid = 4038520 | pmc = 254658 }}</ref>
The fish rhabdovirus IHNV has a bullet-shaped virion containing an unsegmented, negative-sense, single-stranded RNA genome of about 11,000 nucleotides that encode six proteins in this order: a nucleoprotein (N), a phosphoprotein (P), a matrix protein (M), a glycoprotein (G), a nonvirion protein (NV), and a polymerase (L).<ref>{{ cite journal |author1=Kurath, G. |author2=Leong, J. C. | title = Characterization of Infectious Hematopoietic Necrosis Virus mRNA Species Reveals a Nonvirion Rhabdovirus Protein | journal = Journal of Virology | volume = 53 | issue = 2 | pages = 462–468 |date=February 1985 |doi=10.1128/JVI.53.2.462-468.1985 | pmid = 4038520 | pmc = 254658 }}</ref>


To date, the complete genome sequence has been available for only three IHNV isolates.<ref>{{ cite journal |author1=Schütze, H. |author2=Enzmann, P. J. |author3=Kuchling, R. |author4=Mundt, E. |author5=Niemann, H. |author6=Mettenleiter, T. C. | title = Complete Genomic Sequence of the Fish Rhabdovirus Infectious Haematopoietic Necrosis Virus | journal = The Journal of General Virology | volume = 76 | issue = 10 | pages = 2519–2527 |date=October 1995 | pmid = 7595355 | doi = 10.1099/0022-1317-76-10-2519 }}</ref><ref>{{ cite journal |author1=Morzunov, S. P. |author2=Winton, J. R. |author3=Nichol, S. T. | title = The complete Genome Structure and Phylogenetic Relationship of Infectious Hematopoietic Necrosis Virus | journal = Virus Research | volume = 38 | issue = 2–3 | pages = 175–192 |date=October 1995 | pmid = 8578857 | doi = 10.1016/0168-1702(95)00056-V }}</ref><ref>{{ cite journal |author1=Ammayappan, A. |author2=LaPatra, S. E. |author3=Vakharia, V. N. | title = Molecular Characterization of the Virulent Infectious Hematopoietic Necrosis Virus (IHNV) Strain 220-90 | journal = Virology Journal | volume = 7 | issue = | pages = 10 | year = 2010 | pmid = 20085652 | pmc = 2820013 | doi = 10.1186/1743-422X-7-10 }}</ref>
To date, the complete genome sequence has been available for only three IHNV isolates.<ref>{{ cite journal |author1=Schütze, H. |author2=Enzmann, P. J. |author3=Kuchling, R. |author4=Mundt, E. |author5=Niemann, H. |author6=Mettenleiter, T. C. | title = Complete Genomic Sequence of the Fish Rhabdovirus Infectious Haematopoietic Necrosis Virus | journal = The Journal of General Virology | volume = 76 | issue = 10 | pages = 2519–2527 |date=October 1995 | pmid = 7595355 | doi = 10.1099/0022-1317-76-10-2519 |doi-access=free }}</ref><ref>{{ cite journal |author1=Morzunov, S. P. |author2=Winton, J. R. |author3=Nichol, S. T. | title = The complete Genome Structure and Phylogenetic Relationship of Infectious Hematopoietic Necrosis Virus | journal = Virus Research | volume = 38 | issue = 2–3 | pages = 175–192 |date=October 1995 | pmid = 8578857 | doi = 10.1016/0168-1702(95)00056-V }}</ref><ref>{{ cite journal |author1=Ammayappan, A. |author2=LaPatra, S. E. |author3=Vakharia, V. N. | title = Molecular Characterization of the Virulent Infectious Hematopoietic Necrosis Virus (IHNV) Strain 220-90 | journal = Virology Journal | volume = 7 | pages = 10 | year = 2010 | pmid = 20085652 | pmc = 2820013 | doi = 10.1186/1743-422X-7-10 |doi-access=free }}</ref>


Five genotypes have been identified to date.<ref name=Nishizawa2006 /><ref name=he2013>{{cite journal |doi=10.1016/j.meegid.2013.05.014 |pmid=23722020 |title=Dating the divergence of the infectious hematopoietic necrosis virus |journal=Infection, Genetics and Evolution |volume=18 |year=2013 |last1=He |first1=Mei |last2=Ding |first2=Nai-Zheng |last3=He |first3=Cheng-Qiang |last4=Yan |first4=Xue-Chun |last5=Teng |first5=Chun-Bo }}</ref> One of these appears to be unique to Japan.
Five genotypes have been identified to date.<ref name=Nishizawa2006 /><ref name=he2013>{{cite journal |doi=10.1016/j.meegid.2013.05.014 |pmid=23722020 |title=Dating the divergence of the infectious hematopoietic necrosis virus |journal=Infection, Genetics and Evolution |volume=18 |pages=145–50 |year=2013 |last1=He |first1=Mei |last2=Ding |first2=Nai-Zheng |last3=He |first3=Cheng-Qiang |last4=Yan |first4=Xue-Chun |last5=Teng |first5=Chun-Bo }}</ref> One of these appears to be unique to Japan.


The virus appears to have evolved in North America. European strains appear to have evolved from a single genotype (M) suggesting a single introductory event.<ref name=Enzmann2005>{{cite journal |doi=10.3354/dao066187 |pmid=16261933 |title=Infectious hematopoietic necrosis virus: Monophyletic origin of European isolates from North American Genogroup M |journal=Diseases of Aquatic Organisms |volume=66 |issue=3 |pages=187–95 |year=2005 |last1=Enzmann |first1=PJ |last2=Kurath |first2=G |last3=Fichtner |first3=D |last4=Bergmann |first4=SM }}</ref>
The virus appears to have evolved in North America. European strains appear to have evolved from a single genotype (M) suggesting a single introductory event.<ref name=Enzmann2005>{{cite journal |doi=10.3354/dao066187 |pmid=16261933 |title=Infectious hematopoietic necrosis virus: Monophyletic origin of European isolates from North American Genogroup M |journal=Diseases of Aquatic Organisms |volume=66 |issue=3 |pages=187–95 |year=2005 |last1=Enzmann |first1=PJ |last2=Kurath |first2=G |last3=Fichtner |first3=D |last4=Bergmann |first4=SM |doi-access=free }}</ref>


==Evolution==
==Evolution==


This virus appears to have evolved before the 1950s when it was first reported.<ref name="he2013"/>
This virus appears to have evolved before the 1950s when it was first reported.<ref>{{cite journal |doi=10.1016/j.meegid.2013.05.014 |pmid=23722020 |title=Dating the divergence of the infectious hematopoietic necrosis virus |journal=Infection, Genetics and Evolution |volume=18 |pages=145–50 |year=2013 |last1=He |first1=Mei |last2=Ding |first2=Nai-Zheng |last3=He |first3=Cheng-Qiang |last4=Yan |first4=Xue-Chun |last5=Teng |first5=Chun-Bo }}</ref>


==IHNV replication cycle==
==IHNV replication cycle==
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==Transmission==
==Transmission==
Reservoirs of IHNV are clinically infected fish and covert carriers among cultured, feral. or wild fish. Viruses are shed via urine, sexual fluids, and from external mucus, whereas kidney, spleen, and other internal organs are the sites where the virus is most abundant during the course of overt infection.<ref>{{ cite journal | author = Amend, D. F. | title = Detection and Transmission of Infectious Hematopoietic Necrosis Virus in Rainbow Trout | journal = Journal of Wildlife Diseases | volume = 11 | issue = 4 | pages = 471–478 |date=October 1975 | pmid = 1195486 | doi=10.7589/0090-3558-11.4.471}}</ref> Insects, annelids, and crustaceans may act as viral vectors. The potential for epizootics is highest at 10&nbsp;°C and the disease does not occur naturally above 15&nbsp;°C.<ref>{{ cite journal | author = Amend, D. F. | year = 1975 | title = Control of Infectious Hematopoietic Necrosis Virus Disease by Elevating the Water Temperature | journal = Journal of the Fisheries Research Board of Canada | volume = 27 | issue = 2 | doi = 10.1139/f70-034 | pages = 265–270 }}</ref>
Reservoirs of IHNV are clinically infected fish and covert carriers among cultured, feral. or wild fish. Viruses are shed via urine, sexual fluids, and from external mucus, whereas kidney, spleen, and other internal organs are the sites where the virus is most abundant during the course of overt infection.<ref>{{ cite journal | author = Amend, D. F. | title = Detection and Transmission of Infectious Hematopoietic Necrosis Virus in Rainbow Trout | journal = Journal of Wildlife Diseases | volume = 11 | issue = 4 | pages = 471–478 |date=October 1975 | pmid = 1195486 | doi=10.7589/0090-3558-11.4.471| doi-access = free }}</ref> Insects, annelids, and crustaceans may act as viral vectors. The potential for epizootics is highest at 10&nbsp;°C and the disease does not occur naturally above 15&nbsp;°C.<ref>{{ cite journal | author = Amend, D. F. | year = 1975 | title = Control of Infectious Hematopoietic Necrosis Virus Disease by Elevating the Water Temperature | journal = Journal of the Fisheries Research Board of Canada | volume = 27 | issue = 2 | doi = 10.1139/f70-034 | pages = 265–270 }}</ref>


==Clinical signs==
==Clinical signs==
Clinical signs of [[infection]] with IHNV include [[abdominal distension]], bulging of the eyes, skin darkening, abnormal behavior, [[anemia]], and fading of the [[gill]]s. Infected fish commonly [[hemorrhage]] in several areas - the mouth and behind the head, the [[pectoral fin]]s, muscles near the [[anus]], and (in fry) the [[yolk sac]]. Diseased fish weaken eventually floating “belly-up” on the surface of the water.
Clinical signs of [[infection]] with IHNV include [[abdominal distension]], bulging of the eyes, skin darkening, abnormal behavior, [[anemia]], and fading of the [[gill]]s. Infected fish commonly [[hemorrhage]] in several areas - the mouth and behind the head, the [[pectoral fin]]s, muscles near the [[anus]], and (in fry) the [[yolk sac]]. Diseased fish weaken eventually floating “belly-up” on the surface of the water.


[[Necrosis]] is common in the [[kidney]] and [[spleen]], and sometimes in the [[liver]].<ref>{{ cite web | url = http://www.cfsph.iastate.edu/Factsheets/pdfs/infectious_hematopoietic_necrosis.pdf | format = pdf | title = Infectious Hematopoietic Necrosis | work = Factsheets | publisher = The Center for Food Security & Public Health, Iowa State University }}</ref> Mortality is very high in young fish.
[[Necrosis]] is common in the [[kidney]] and [[spleen]], and sometimes in the [[liver]].<ref>{{ cite web | url = http://www.cfsph.iastate.edu/Factsheets/pdfs/infectious_hematopoietic_necrosis.pdf | title = Infectious Hematopoietic Necrosis | work = Factsheets | publisher = The Center for Food Security & Public Health, Iowa State University }}</ref> Mortality is very high in young fish.


Some fish become covert carriers of the virus if they survive infection.
Some fish become covert carriers of the virus if they survive infection.
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This virus was first reported in Europe in 1987 in France and Italy. It was reported in 1992 in Germany.
This virus was first reported in Europe in 1987 in France and Italy. It was reported in 1992 in Germany.

In April, 2018 according Scientist discovery Juvenile Salmon and Steelhead on Columbia River Basin in Pacific Northwest, that prevent release and spread disease in ocean.<ref>{{Cite web | url=http://www.spokesman.com/stories/2018/apr/24/study-traces-ihnv-virus-in-salmon/ | title=Study traces IHNV virus in salmon &#124; the Spokesman-Review}}</ref>


==References==
==References==
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== External links ==
== External links ==
* {{cite web | url = http://www.crl-fish.eu/ | title = European Community Reference Laboratory for Fish Diseases | deadurl = yes | archiveurl = http://arquivo.pt/wayback/20141127111700/http://www.crl-fish.eu/ | archivedate = 2014-11-27 | df = }}
* {{cite web | url = http://www.crl-fish.eu/ | title = European Community Reference Laboratory for Fish Diseases | url-status = dead | archive-url = http://arquivo.pt/wayback/20141127111700/http://www.crl-fish.eu/ | archive-date = 2014-11-27 }}
* {{ cite web | url = http://www.fishpathogens.eu/ | title = Fishpathogens.eu }} A database on IHNV isolates and their sequences
* {{ cite web | url = http://www.fishpathogens.eu/ | title = Fishpathogens.eu }} A database on IHNV isolates and their sequences
* {{ cite web | title = Infectious Haematopoietic Necrosis | url = http://en.wikivet.net/Infectious_Haematopoietic_Necrosis | publisher = WikiVet | accessdate = 2012-02-25 }}
* {{ cite web | title = Infectious Haematopoietic Necrosis | url = http://en.wikivet.net/Infectious_Haematopoietic_Necrosis | publisher = WikiVet | access-date = 2012-02-25 }}


{{fish disease topics}}
{{Fish disease topics}}
{{Taxonbar|from=Q880931}}
{{Authority control}}


{{DEFAULTSORT:Infectious Hematopoietic Necrosis Virus}}
{{DEFAULTSORT:Infectious Hematopoietic Necrosis Virus}}

Revision as of 05:15, 4 January 2024

Salmonid novirhabdovirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family: Rhabdoviridae
Genus: Novirhabdovirus
Species:
Salmonid novirhabdovirus
Synonyms
  • Infectious hematopoietic necrosis virus

Infectious hematopoietic necrosis virus (IHNV), is a negative-sense single-stranded, bullet-shaped RNA virus that is a member of the Rhabdoviridae family, and from the genus Novirhabdovirus. It causes the disease known as infectious hematopoietic necrosis in salmonid fish such as trout and salmon. The disease may be referred to by a number of other names such as Chinook salmon disease, Coleman disease, Columbia River sockeye disease, Cultus Lake virus disease, Oregon sockeye disease, Sacramento River Chinook disease and sockeye salmon viral disease. IHNV is commonly found in the Pacific Coast of Canada and the United States, and has also been found in Europe and Japan.[1][2][3] The first reported epidemics of IHNV occurred in the United States at the Washington and the Oregon fish hatcheries during the 1950s.[4] IHNV is transmitted following shedding of the virus in the feces, urine, sexual fluids, and external mucus and by direct contact or close contact with the surrounding water. The virus gains entry into fish at the base of the fins.[5]

The disease is listed as a nonexotic disease of the EU and is therefore watched closely by the European Community Reference Laboratory for Fish Diseases. To keep track of the distribution of different IHNV genotypes, a database called Fishpathogens.eu[6] has been created to store data on different fish pathogens (including IHNV) and their sequences.

Classification

IHNV is the causal agent of infectious hematopoietic necrosis (IHN) disease of fish and is a negative-sense single-stranded RNA virus. IHNV is a member of the genus Novirhabdovirus,[7] belongs to the family of Rhabdoviridae. The North American IHNV isolates are grouped based on the partial glycoprotein (G) gene sequences.[8] The three major IHNV genogroups in North America are designated as U, M, and L for the upper, middle and lower portions of IHNV geographical range in North America. The Japanese and Korean isolates constitute a new Japanese rainbow trout genogroup.[2][9]

Virion

Virions consist of an envelope and a nucleocapsid. Virions are bullet-shaped and measure 45-100 nm in diameter, and 100-430 nm in length.[10] Surface projections are densely dispersed, distinctive spikes that cover the whole surface except for the quasiplanar end.

Genome organization

The fish rhabdovirus IHNV has a bullet-shaped virion containing an unsegmented, negative-sense, single-stranded RNA genome of about 11,000 nucleotides that encode six proteins in this order: a nucleoprotein (N), a phosphoprotein (P), a matrix protein (M), a glycoprotein (G), a nonvirion protein (NV), and a polymerase (L).[11]

To date, the complete genome sequence has been available for only three IHNV isolates.[12][13][14]

Five genotypes have been identified to date.[2][15] One of these appears to be unique to Japan.

The virus appears to have evolved in North America. European strains appear to have evolved from a single genotype (M) suggesting a single introductory event.[16]

Evolution

This virus appears to have evolved before the 1950s when it was first reported.[15]

IHNV replication cycle

The rhabdoviral cycle of infection occurs by series of events in this order: adsorption, penetration and uncoating, transcription, translation, replication, assembly, and budding.

Transmission

Reservoirs of IHNV are clinically infected fish and covert carriers among cultured, feral. or wild fish. Viruses are shed via urine, sexual fluids, and from external mucus, whereas kidney, spleen, and other internal organs are the sites where the virus is most abundant during the course of overt infection.[17] Insects, annelids, and crustaceans may act as viral vectors. The potential for epizootics is highest at 10 °C and the disease does not occur naturally above 15 °C.[18]

Clinical signs

Clinical signs of infection with IHNV include abdominal distension, bulging of the eyes, skin darkening, abnormal behavior, anemia, and fading of the gills. Infected fish commonly hemorrhage in several areas - the mouth and behind the head, the pectoral fins, muscles near the anus, and (in fry) the yolk sac. Diseased fish weaken eventually floating “belly-up” on the surface of the water.

Necrosis is common in the kidney and spleen, and sometimes in the liver.[19] Mortality is very high in young fish.

Some fish become covert carriers of the virus if they survive infection.

Diagnosis

Clinical signs and history of previous outbreaks may be suggestive of IHN. Staphylococcal agglutination, virus neutralisation (VN), indirect fluorescent antibody testing, ELISA, PCR, and DNA probe technology techniques can be used to confirm diagnosis. The gold standard is virus neutralisation. Alternatively, the identification of degeneration and necrosis of granular cells in the lamina propria, stratum compactum, and stratum granulosum of the gastrointestinal tract on histopathology can be used to diagnose infection.

Treatment and control

No treatment had yet proven to be effective. To prevent the disease, strict isolation, hygiene, and testing procedures should be in place.

History

This virus was first reported in Europe in 1987 in France and Italy. It was reported in 1992 in Germany.

In April, 2018 according Scientist discovery Juvenile Salmon and Steelhead on Columbia River Basin in Pacific Northwest, that prevent release and spread disease in ocean.[20]

References

  1. ^ Rudakova, S. L.; Kurath, G.; Bochkova, E. V. (March 2007). "Occurrence and Genetic Typing of Infectious Hematopoietic Necrosis Virus in Kamchatka, Russia". Diseases of Aquatic Organisms. 75 (1): 1–11. doi:10.3354/dao075001. PMID 17523538.
  2. ^ a b c Nishizawa, T.; Kinoshita, S.; Kim, W. S.; Higashi, S.; Yoshimizu, M. (August 2006). "Nucleotide Diversity of Japanese Isolates of Infectious Hematopoietic Necrosis Virus (IHNV) Based on the Glycoprotein Gene". Diseases of Aquatic Organisms. 71 (3): 267–272. doi:10.3354/dao071267. hdl:2115/43977. PMID 17058607.
  3. ^ Enzmann, P. J.; Kurath, G.; Fichtner, D.; Bergmann, S. M. (September 2005). "Infectious Hematopoietic Necrosis Virus: Monophyletic Origin of European Isolates from North American Genogroup M". Diseases of Aquatic Organisms. 66 (3): 187–195. doi:10.3354/dao066187. PMID 16261933.
  4. ^ Rucker, R. R.; Whipple, W. J.; Parvin, J. R.; Evans, C. A. (1953). "A Contagious Disease of Salmon Possibly of Virus Origin". Fishery Bulletin. 76: 35–46.
  5. ^ Harmache, A.; LeBerre, M.; Droineau, S.; Giovannini, M.; Brémont, M. (April 2006). "Bioluminescence Imaging of Live Infected Salmonids Reveals that the Fin Bases are the Major Portal of Entry for Novirhabdovirus". Journal of Virology. 80 (7): 3655–3659. doi:10.1128/JVI.80.7.3655-3659.2006. PMC 1440417. PMID 16537634.
  6. ^ "Fishpathogens.eu Database". Epizone - European Community Reference Laboratory for Fish Diseases.
  7. ^ "ICTVdB Virus Code: 01.062.0.06.001". National Institutes of Health. 19 January 2023.
  8. ^ Kurath, G.; Garver, K. A.; Troyer, R. M.; Emmenegger, E. J.; Einer-Jensen, K.; Anderson, E. D. (April 2003). "Phylogeography of Infectious Haematopoietic Necrosis Virus in North America". The Journal of General Virology. 84 (4): 803–814. doi:10.1099/vir.0.18771-0. PMID 12655081.
  9. ^ Kim, W. S.; Oh, M. J.; Nishizawa, T.; Park, J. W.; Kurath, G.; Yoshimizu, M. (2007). "Genotyping of Korean Isolates of Infectious Hematopoietic Necrosis Virus (IHNV) Based on the Glycoprotein Gene". Archives of Virology. 152 (11): 2119–2124. doi:10.1007/s00705-007-1027-9. hdl:2115/32293. PMID 17668275. S2CID 10041775.
  10. ^ Hill, B. J.; Underwood, B. O.; Smale, C. J.; Brown, F. (June 1975). "Physico-Chemical and Serological Characterization of five Rhabdoviruses Infecting Fish". The Journal of General Virology. 27 (3): 369–378. doi:10.1099/0022-1317-27-3-369. PMID 1170278.
  11. ^ Kurath, G.; Leong, J. C. (February 1985). "Characterization of Infectious Hematopoietic Necrosis Virus mRNA Species Reveals a Nonvirion Rhabdovirus Protein". Journal of Virology. 53 (2): 462–468. doi:10.1128/JVI.53.2.462-468.1985. PMC 254658. PMID 4038520.
  12. ^ Schütze, H.; Enzmann, P. J.; Kuchling, R.; Mundt, E.; Niemann, H.; Mettenleiter, T. C. (October 1995). "Complete Genomic Sequence of the Fish Rhabdovirus Infectious Haematopoietic Necrosis Virus". The Journal of General Virology. 76 (10): 2519–2527. doi:10.1099/0022-1317-76-10-2519. PMID 7595355.
  13. ^ Morzunov, S. P.; Winton, J. R.; Nichol, S. T. (October 1995). "The complete Genome Structure and Phylogenetic Relationship of Infectious Hematopoietic Necrosis Virus". Virus Research. 38 (2–3): 175–192. doi:10.1016/0168-1702(95)00056-V. PMID 8578857.
  14. ^ Ammayappan, A.; LaPatra, S. E.; Vakharia, V. N. (2010). "Molecular Characterization of the Virulent Infectious Hematopoietic Necrosis Virus (IHNV) Strain 220-90". Virology Journal. 7: 10. doi:10.1186/1743-422X-7-10. PMC 2820013. PMID 20085652.
  15. ^ a b He, Mei; Ding, Nai-Zheng; He, Cheng-Qiang; Yan, Xue-Chun; Teng, Chun-Bo (2013). "Dating the divergence of the infectious hematopoietic necrosis virus". Infection, Genetics and Evolution. 18: 145–50. doi:10.1016/j.meegid.2013.05.014. PMID 23722020.
  16. ^ Enzmann, PJ; Kurath, G; Fichtner, D; Bergmann, SM (2005). "Infectious hematopoietic necrosis virus: Monophyletic origin of European isolates from North American Genogroup M". Diseases of Aquatic Organisms. 66 (3): 187–95. doi:10.3354/dao066187. PMID 16261933.
  17. ^ Amend, D. F. (October 1975). "Detection and Transmission of Infectious Hematopoietic Necrosis Virus in Rainbow Trout". Journal of Wildlife Diseases. 11 (4): 471–478. doi:10.7589/0090-3558-11.4.471. PMID 1195486.
  18. ^ Amend, D. F. (1975). "Control of Infectious Hematopoietic Necrosis Virus Disease by Elevating the Water Temperature". Journal of the Fisheries Research Board of Canada. 27 (2): 265–270. doi:10.1139/f70-034.
  19. ^ "Infectious Hematopoietic Necrosis" (PDF). Factsheets. The Center for Food Security & Public Health, Iowa State University.
  20. ^ "Study traces IHNV virus in salmon | the Spokesman-Review".

External links

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