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{{short description|American biochemist}}
{{Infobox scientist
{{Infobox scientist
| name = Joseph DeRisi
| name = Joseph DeRisi
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| residence = US
| nationality = [[United States|American]]
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| field = [[Biology]]
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| doctoral_students =
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| known_for = ViroChip, work on identifying [[SARS]] virus, gene expression in [[Plasmodium falciparum]]
| known_for = ViroChip, work on identifying [[SARS]] virus, gene expression in [[Plasmodium falciparum]]
| thesis_title = The Analysis of whole genome gene expression in the budding yeast ''Saccharomyces cerevisiae''.
| author_abbreviation_bot =
| thesis_url = http://www.worldcat.org/oclc/864911180
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| thesis_year = 1999
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'''Joseph DeRisi''' is an [[United States|American]] [[biochemist]], specializing in [[molecular biology]], [[parasitology]], [[genomics]], [[virology]], and [[computational biology]].
'''Joseph Lyman DeRisi''' is an American [[biochemist]], specializing in [[molecular biology]], [[parasitology]], [[genomics]], [[virology]], and [[computational biology]].
==Early life and education==
DeRisi was raised in [[Carmichael, California]], where he graduated from [[Del Campo High School]].<ref>{{Cite web| title = Dr. Joe Derisi| work = San Juan Education Foundation| accessdate = 2022-10-17| url = https://www.sanjuaneducationfoundation.org/joe-derisi}}</ref> He received a B.A. in Biochemistry and Molecular Biology in 1992 from the [[University of California, Santa Cruz]].<ref name=UCSFPBBR>{{Cite web| title =Sandler Program for Breakthrough Biomedical Research: Our Leadership | work = UCSF Sandler Program for Breakthrough Biomedical Research | accessdate = 2022-10-28| url =https://pbbr.ucsf.edu/about/our-leadership }}</ref>


DeRisi earned his Ph.D. in biochemistry from [[Stanford University]] in 1999. Working in the laboratory of [[Patrick O. Brown]], he developed methods for the production and use of [[DNA microarrays]] in molecular biology, and his thesis was a genome-wide expression analysis of the budding yeast [[S. cerevisiae]].<ref>{{Cite thesis| last = DeRisi| first = Joseph L.| title = The Analysis of whole genome gene expression in the budding yeast Saccharomyces cerevisiae| work = SearchWorks Stanford |url =https://searchworks.stanford.edu/view/13356561 | date = 1999 | oclc = 80580640|accessdate=2022-10-18}}</ref><ref name=Economist120206>{{Cite news|last = Kahn| first = Jennifer| title = New Chips on the Block | work = The Economist Technology Quarterly| accessdate = 2022-10-12| date = 2006-12-02| url = https://www.economist.com/sites/default/files/special-reports-pdfs/8312145_0.pdf}}</ref><ref name=Stanford>{{Cite news| volume = Summer 2002| last = Adams| first = Amy| title=PhD alum Joe DeRisi brings innovation to the masses | work = Stanford Medicine Magazine| accessdate = 2022-10-18| url = https://sm.stanford.edu/archive/stanmed/2002summer/md-populist.html}}</ref> Upon graduation, DeRisi accepted a position as a Sandler Fellow at the [[University of California San Francisco]].<ref name=UCSFPBBR/><ref name=Scientist112005>{{Cite news| last = Hopkin| first = Karen| title = SARS, Malaria, and the Microarray| work = The Scientist Magazine| accessdate = 2022-10-17| date = 2005-11-20| url = https://www.the-scientist.com/reverse-transcript/sars-malaria-and-the-microarray-48134}}</ref>
==Life==
He received a B.A. in Biochemistry and Molecular Biology (1992) from the [[University of California, Santa Cruz]], and a Ph.D. in Biochemistry (1999) from [[Stanford University]].


==Career and research==
Joseph DeRisi is currently a [[Howard Hughes Medical Institute]] (HHMI) Investigator and a Professor and Chairman of the Department of [[Biochemistry]] and [[Biophysics]] at the [[University of California, San Francisco]] (UCSF) with a joint appointment at the [[California Institute for Quantitative Biosciences]] (QB3).
DeRisi has been a faculty member of the UCSF biochemistry and biophysics department since 1999. As of 2022 he is a professor of biochemistry and biophysics and is also the director of UCSF's Sandler Program for Breakthrough Biomedical Research.<ref name=UCSFPBBR /><ref name=Scientist112005>{{Cite news| last = Hopkin| first = Karen| title = SARS, Malaria, and the Microarray| work = The Scientist Magazine| accessdate = 2022-10-17| date = 2005-11-20| url = https://www.the-scientist.com/reverse-transcript/sars-malaria-and-the-microarray-48134}}</ref>


DeRisi's best-known achievements are printing the first whole genome expression array ({{cite journal | pmid = 9381177 | volume=278 | title=Exploring the metabolic and genetic control of gene expression on a genomic scale | year=1997 | journal=Science | pages=680–6 | last1 = DeRisi | first1 = JL | last2 = Iyer | first2 = VR | last3 = Brown | first3 = PO | doi = 10.1126/science.278.5338.680| citeseerx = 10.1.1.335.7937 }}), performing the first broad analysis of differential gene expression in cancer cells ({{cite journal | pmid = 8944026 | doi=10.1038/ng1296-457 | volume=14 | title=Use of a cDNA microarray to analyse gene expression patterns in human cancer | year=1996 | journal=Nat Genet | pages=457–60 | last1 = DeRisi | first1 = J | last2 = Penland | first2 = L | last3 = Brown | first3 = PO | last4 = Bittner | first4 = ML | last5 = Meltzer | first5 = PS | last6 = Ray | first6 = M | last7 = Chen | first7 = Y | last8 = Su | first8 = YA | last9 = Trent | first9 = JM}}), profiling gene expression throughout the lifecycle of the [[malaria]]-causing protozoan ''[[Plasmodium falciparum]]'',<ref name=Llinas2006>{{citation
DeRisi is known for printing the first whole-[[Microarray|genome expression array]],<ref>{{cite journal | pmid = 9381177 | volume=278 | title=Exploring the metabolic and genetic control of gene expression on a genomic scale | year=1997 | journal=Science | pages=680–6 | last1 = DeRisi | first1 = JL | last2 = Iyer | first2 = VR | last3 = Brown | first3 = PO | issue=5338 | doi = 10.1126/science.278.5338.680| bibcode=1997Sci...278..680D | citeseerx = 10.1.1.335.7937 }}</ref> performing the first broad analysis of differential gene expression in cancer cells,<ref>{{cite journal | pmid = 8944026 | doi=10.1038/ng1296-457 | volume=14 | title=Use of a cDNA microarray to analyse gene expression patterns in human cancer | year=1996 | journal=Nat Genet | pages=457–60 | last1 = DeRisi | first1 = J | last2 = Penland | first2 = L | last3 = Brown | first3 = PO | last4 = Bittner | first4 = ML | last5 = Meltzer | first5 = PS | last6 = Ray | first6 = M | last7 = Chen | first7 = Y | last8 = Su | first8 = YA | last9 = Trent | first9 = JM| issue=4 | s2cid=23091561 }}</ref> profiling gene expression throughout the lifecycle of the [[malaria]]-causing protozoan ''[[Plasmodium falciparum]]'',<ref name=Llinas2006>{{citation
| last1 = Llinas | first1 = Manuel
| last1 = Llinas | first1 = Manuel
| last2 = Bozdech | first2 = Zbynek
| last2 = Bozdech | first2 = Zbynek
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| volume = 34
| volume = 34
| issue = 4
| issue = 4
| pages = 1166
| pages = 1166–73
| doi = 10.1093/nar/gkj517
| doi = 10.1093/nar/gkj517
| pmid = 16493140
| pmid = 16493140
| pmc = 1380255
| pmc = 1380255
}}</ref> his discovery of the [[SARS]] virus,<ref name=Rota2003>{{citation
}}</ref> genomic characterization of the [[SARS]]-CoV-1 virus,<ref name=Rota2003>{{citation
| last1 = Rota | first1 = Paul A.
| last1 = Rota | first1 = Paul A.
| last2 = Oberste | first2 = M. Steven
| last2 = Oberste | first2 = M. Steven
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| last9 = Maher | first9 = Kaija
| last9 = Maher | first9 = Kaija
| last10 = Bellini | first10 = William J.
| last10 = Bellini | first10 = William J.
| year = 2003
| year = 2003
| title = Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
| title = Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
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| volume = 300
| volume = 300
| issue = 5624
| issue = 5624
| pages = 1394
| pages = 1394–9
| doi = 10.1126/science.1085952
| doi = 10.1126/science.1085952
| pmid = 12730500
| pmid = 12730500
| bibcode = 2003Sci...300.1394R
| doi-access = free
| doi-access = free
}}</ref> and pioneering virus discovery using gene hybridization array and DNA sequencing technologies ({{cite journal | pmid = 12429852 | doi=10.1073/pnas.242579699 | volume=99 | title=Microarray-based detection and genotyping of viral pathogens | pmc=137777 | year=2002 | journal=Proc Natl Acad Sci U S A | pages=15687–92 | last1 = Wang | first1 = D | last2 = Coscoy | first2 = L | last3 = Zylberberg | first3 = M | last4 = Avila | first4 = PC | last5 = Boushey | first5 = HA | last6 = Ganem | first6 = D | last7 = DeRisi | first7 = JL}}). Joe is also known for tackling any "cool problem" whatsoever, which generally come in the form of biological questions complicated by obstacles not surmountable without invention of new protocols and techniques.
}}</ref> and pioneering virus discovery using gene hybridization arrays and DNA sequencing technologies.<ref>{{cite journal | pmid = 12429852 | doi=10.1073/pnas.242579699 | volume=99 | title=Microarray-based detection and genotyping of viral pathogens | pmc=137777 | year=2002 | journal=Proc Natl Acad Sci U S A | pages=15687–92 | last1 = Wang | first1 = D | last2 = Coscoy | first2 = L | last3 = Zylberberg | first3 = M | last4 = Avila | first4 = PC | last5 = Boushey | first5 = HA | last6 = Ganem | first6 = D | last7 = DeRisi | first7 = JL| issue=24 | bibcode=2002PNAS...9915687W | doi-access=free }}</ref>


DeRisi uses [[microarray]]s extensively in his work, and has designed and built both hardware and software for microarrays. He is a proponent of [[Open access (publishing)|open access]] to microarray technology,{{Citation needed|date=December 2008}} and maintains a website with software and protocols for microarray operations.{{Citation needed|date=December 2008}} He is also a proponent of [[open access publishing]],{{Citation needed|date=December 2008}} and has publications in the [[Public Library of Science]] journals.<ref name=Bozdech2003>{{citation
In his early career, DeRisi was a pioneer of [[microarray]]s, and designed and built both hardware and software for microarrays. He was a proponent of [[Open access (publishing)|open access]] to microarray technology,<ref name=Stanford>{{Cite news| volume = Summer 2002| last = Adams| first = Amy| title=PhD alum Joe DeRisi brings innovation to the masses | work = Stanford Medicine Magazine| accessdate = 2022-10-18| url = https://sm.stanford.edu/archive/stanmed/2002summer/md-populist.html}}</ref> and maintained a website with software and protocols for microarray operations.<ref name=Economist120206>{{Cite news|last = Kahn| first = Jennifer| title = New Chips on the Block | work = The Economist Technology Quarterly| accessdate = 2022-10-12| date = 2006-12-02| url = https://www.economist.com/sites/default/files/special-reports-pdfs/8312145_0.pdf}}</ref> He is also a proponent of [[open access publishing]].<ref name=SFG092804/>
| last1 = Bozdech | first1 = Zbynek
| last2 = Llinás | first2 = Manuel
| last3 = Pulliam | first3 = Brian Lee
| last4 = Wong | first4 = Edith D.
| last5 = Zhu | first5 = Jingchun
| last6 = Derisi | first6 = Joseph L.
| year = 2003
| title = The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum
| journal = PLoS Biology
| volume = 1
| pages = e5
| doi = 10.1371/journal.pbio.0000005
| pmid = 12929205
| issue = 1
| pmc = 176545
}} {{open access}}</ref>


In 2002, DeRisi and his research collaborator David Wang developed the ViroChip, a DNA microarray that could be used to rapidly identify viruses in a sample of blood or tissue.<ref name=NYT060321/> He used the tool to help identify the [[Severe acute respiratory syndrome|SARS-CoV-1]] virus in 2003. In 2004, DeRisi was named a [[MacArthur Foundation|MacArthur fellow]] for his work with ViroChip and genomic diagnostic techniques.<ref name=SFG092804>{{Cite news| last = Russell| first = Sabin| title = THE MACARTHUR GRANTS: BAY AREA PROFILES / His quick work on SARS gave crucial answers| work = SF Gate| accessdate = 2022-10-28| date = 2004-09-28| url = https://www.sfgate.com/bayarea/article/THE-MACARTHUR-GRANTS-BAY-AREA-PROFILES-His-2721757.php}}</ref><ref>{{Cite web| title = Joseph DeRisi| work = Macarthur Foundation| accessdate = 2022-11-01| url = https://www.macfound.org/fellows/class-of-2004/joseph-derisi}}</ref>
DeRisi has identified putative disease-causing viruses in humans (cancer, SARS, other respiratory infections, etc.), and animals ranging from parrots and cockatiels to honeybees and boa constrictors. He and a research partner, [[Don Ganem]], have identified a parasite, ''[[Nosema ceranae]]'', that appears to be responsible for colony collapse among honeybees. http://today.ucsf.edu/stories/ucsf-sleuths-identify-suspects-in-mystery-of-vanishing-honeybees/. He has also de-bunked the relation of viruses to certain subsets of human cancer.


DeRisi became a [[Howard Hughes Medical Institute]] (HHMI) investigator in 2005, and received financial support from HHMI for his research.<ref name=Scientist112005/><ref>{{Cite web| last = O'Brien| first = Jennifer | title = Two UCSF Scientists Named Howard Hughes Medical Institute Investigators {{!}} UC San Francisco| work = UCSF| accessdate = 2022-10-31| date = 2005-03-22| url = https://www.ucsf.edu/news/2005/03/101288/two-ucsf-scientists-named-howard-hughes-medical-institute-investigators}}</ref> He remained an investigator until 2016.<ref>{{Cite web| title = Joseph L. DeRisi| work = HHMI| format = Text | accessdate = 2022-10-31| url = https://www.hhmi.org/scientists/joseph-l-derisi}}</ref>
Perhaps most relevant to contemporary global health, based on extensive characterization of the malaria-causing pathogen, Plasmodium falciparum, DeRisi's group has developed profoundly promising candidate drugs to cure malaria and a model for a vaccine to prevent malaria.


DeRisi and his colleagues employ metagenomic next-generation sequencing (mNGS) for applications including to identify the causal agents in cases of infectious encephalitis and meningitis and to discriminate between autoimmune and infectious causes, diagnosing cases that are difficult to decipher using traditional clinical laboratory techniques.<ref name=NYT060321>{{Cite news| issn = 0362-4331| last = Kahn| first = Jennifer| title = The Disease Detective| work = The New York Times| accessdate = 2022-10-12| date = 2021-06-03| url = https://www.nytimes.com/2021/06/03/magazine/metagenomic-sequencing.html}}</ref><ref name=Atlantic101618>{{Cite news| last = Yong| first = Ed| title = A Simpler Way to Get to the Bottom of Mysterious Illnesses in Poor Countries| work = The Atlantic| accessdate = 2022-11-01| date = 2018-10-16| url = https://www.theatlantic.com/science/archive/2018/10/dashboard-disease-detectives/573034/}}</ref> Using metagenomic sequencing, DeRisi has identified disease-causing viruses in humans, and in animals ranging from parrots and cockatiels to honeybees and boa constrictors.<ref name=NYT060321/><ref>{{cite journal |last1= Dubey|first1= Divyanshu |last2= Mandel-Brehm|first2= Caleigh |date= July 4, 2019|title= Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis|journal= The New England Journal of Medicine|volume= 381 |issue= 1 |pages= 47–54 |doi= 10.1056/NEJMoa1816721|pmid= 31269365 |pmc= 6800027 |doi-access= free}}</ref> He and a research partner, [[Don Ganem]], have identified a parasite, ''[[Nosema ceranae]]'', that appears to be responsible for colony collapse among honeybees.<ref>{{Cite web |title=UCSF Sleuths Identify Suspects in Mystery of Vanishing Honeybees |url=https://www.ucsf.edu/news/2007/04/7229/ucsf-sleuths-identify-suspects-mystery-vanishing-honeybees |access-date=October 28, 2022 |website=UCSF.com|date=25 April 2007 }}</ref> He has also de-bunked the relation of viruses to certain subsets of human cancer.<ref name= "SFChronicle2">{{cite web |last= Allday |first= Erin |date= July 15, 2019 |title= Rare disease discovery: Antibodies fighting cancer go on to attack brain | url= https://www.sfchronicle.com/bayarea/article/Rare-disease-discovery-Antibodies-fighting-14094823.php| website= sfchronicle.com | access-date= May 1, 2021}}</ref>
In 2004 DeRisi was named a [[MacArthur Foundation|MacArthur fellow]] (the "Genius" award), in 2008 was awarded the 14th Annual [[Heinz Award]] for Technology, the Economy, and Employment, and in 2014 he received the John J. Carty Award for the Advancement of Science from the National Academy of Sciences.
In 2016 he was elected to the [[National Academy of Sciences]].<ref>{{citation|url=http://www.nasonline.org/news-and-multimedia/news/may-3-2016-NAS-Election.html|title=National Academy of Sciences Members and Foreign Associates Elected|department=News from the National Academy of Sciences|publisher=[[National Academy of Sciences]]|date=May 3, 2016|accessdate=2016-05-14|archive-url=https://web.archive.org/web/20160506052951/http://www.nasonline.org/news-and-multimedia/news/may-3-2016-NAS-Election.html|archive-date=May 6, 2016|url-status=dead}}.</ref>


DeRisi and his colleague Dr. Michael Wilson used a [[phage display]] to screen antibody samples from patients with autoimmune symptoms against a library of human proteins, allowing them to identify a cancer-associated [[autoantigen]] that is the cause of the symptoms.<ref name= "SFChronicle2"/><ref>{{Cite journal| doi = 10.1056/NEJMoa1816721| issn = 0028-4793| volume = 381| issue = 1| pages = 47–54| last1 = Mandel-Brehm| first1 = Caleigh| last2 = Dubey| first2 = Divyanshu| last3 = Kryzer| first3 = Thomas J.| last4 = O’Donovan| first4 = Brian D.| last5 = Tran| first5 = Baouyen| last6 = Vazquez| first6 = Sara E.| last7 = Sample| first7 = Hannah A.| last8 = Zorn| first8 = Kelsey C.| last9 = Khan| first9 = Lillian M.| last10 = Bledsoe| first10 = Ian O.| last11 = McKeon| first11 = Andrew| last12 = Pleasure| first12 = Samuel J.| last13 = Lennon| first13 = Vanda A.| last14 = DeRisi| first14 = Joseph L.| last15 = Wilson| first15 = Michael R.| last16 = Pittock| first16 = Sean J.| title = Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis| journal = New England Journal of Medicine| accessdate = 2022-11-01| date = 2019-07-04| url = https://doi.org/10.1056/NEJMoa1816721| pmid = 31269365| pmc = 6800027}}</ref>
He was involved in the development of the [[ViroChip]], which is used to rapidly identify viruses in bodily fluids. It was used to help identify the [[Severe acute respiratory syndrome]] virus in 2003. He has also been involved in the development of an online platform called [[IDseq]], backed by the [[Chan Zuckerberg Initiative]] which is used to identify viruses from [[Metagenomics|metagenomic sequencing]] data.<ref>{{cite news |title=A Simpler Way to Get to the Bottom of Mysterious Illnesses in Poor Countries |url=https://www.theatlantic.com/science/archive/2018/10/dashboard-disease-detectives/573034/ |accessdate=27 November 2018 |publisher=The Atlantic |date=16 October 2018}}</ref>


DeRisi’s lab at UCSF also conducts research to understand the genetics of the [[malaria]]-causing pathogen ''[[Plasmodium falciparum]]'', the causative agent of the most deadly form of human malaria.<ref name=SFG092804/><ref name=NYT081203>{{Cite news| issn = 0362-4331| last = Wade| first = Nicholas| title = New Chink in the Armor Of the Malaria Parasite | work = The New York Times| accessdate = 2022-11-01| date = 2003-08-12| url = https://www.nytimes.com/2003/08/12/science/new-chink-in-the-armor-of-the-malaria-parasite.html}}</ref> DeRisi's group has developed candidate drugs to cure malaria.<ref>{{cite journal |last1= Jiménez-Díaz |first1= María |last2= Ebert|first2= Daniel |date= December 1, 2014|title= (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium|journal= Proceedings of the National Academy of Sciences of the United States of America|volume= 111 |issue= 50 |pages= E5455-62 |doi= 10.1073/pnas.1414221111|pmid= 25453091 |pmc= 4273362 |bibcode= 2014PNAS..111E5455J |doi-access= free}}</ref> In 2011, the group determined the function of the apicoplast, a unique [[organelle]] in [[apicomplexa|apicomplexans]], identifying the target of an anti-malarial drug that was a [[preclinical development|preclinical candidate]].<ref>{{Cite news| last = Palca| first = Joe| title = A Remnant From Algae In Malaria Parasite May Prove Its Weakness| work = NPR| accessdate = 2022-11-01| date = 2011-08-30| url = https://www.npr.org/sections/health-shots/2011/08/31/140069350/a-remnant-from-algae-in-malaria-parasite-may-prove-its-weakness}}</ref><ref>{{Cite journal| doi = 10.1371/journal.pbio.1001138| issn = 1545-7885| volume = 9| issue = 8| pages = –1001138| last1 = Yeh| first1 = Ellen| last2 = DeRisi| first2 = Joseph L.| title = Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum| journal = PLOS Biology| date = 2011-08-30| pmid = 21912516| pmc = 3166167| doi-access = free}}</ref>
== Awards ==

In 2016, DeRisi became the co-president of the newly established [[CZ Biohub]], alongside [[Stephen Quake]].<ref name=Nature091120>{{Cite journal| doi = 10.1038/s41587-020-0685-y| issn = 1546-1696| volume = 38| issue = 10| pages = 1116–1120| last = DeFrancesco| first = Laura| title = The making of the Biohub| journal = Nature Biotechnology| date = 2020-09-11| pmid = 32918057| s2cid = 221637469| doi-access = free}}</ref> After joining CZ Biohub, DeRisi established a team of developers to create a cloud-based metagenomic diagnostic platform based on code from his lab at UCSF. The platform, then named IDSeq, was initially launched for testing by a small group in 2018.<ref name=Wired031020>{{Cite magazine| issn = 1059-1028| last = Molteni| first = Megan| title = A Disease Tracker Backed by Gates and Zuckerberg Tackles Covid-19| magazine = Wired |date = 2020-03-10| accessdate = 2022-11-01| url = https://www.wired.com/story/a-disease-tracker-backed-by-gates-and-zuckerberg-tackles-covid-19/}}</ref><ref name=Atlantic101618/> The development and computing costs were backed by the [[Chan Zuckerberg Initiative]] and CZ Biohub.<ref name=Atlantic101618/> The platform is used to rapidly identify pathogens from [[Metagenomics|metagenomic sequencing]] data,<ref>{{Cite journal|last1=Kalantar|first1=Katrina L|last2=Carvalho|first2=Tiago|last3=de Bourcy|first3=Charles F A|last4=Dimitrov|first4=Boris|last5=Dingle|first5=Greg|last6=Egger|first6=Rebecca|last7=Han|first7=Julie|last8=Holmes|first8=Olivia B|last9=Juan|first9=Yun-Fang|last10=King|first10=Ryan|last11=Kislyuk|first11=Andrey|date=October 2020|title=IDseq—An open source cloud-based pipeline and analysis service for metagenomic pathogen detection and monitoring|journal=GigaScience|volume=9|issue=10|doi=10.1093/gigascience/giaa111|pmid=33057676|pmc=7566497|issn=2047-217X|doi-access=free}}</ref> and as of 2022 is known as CZ-ID.<ref>{{Cite journal| doi = 10.1038/s41467-022-31600-0| issn = 2041-1723| volume = 13| issue = 1| pages = 3937| last1 = Mick| first1 = Eran| last2 = Tsitsiklis| first2 = Alexandra| last3 = Spottiswoode| first3 = Natasha| last4 = Caldera| first4 = Saharai| last5 = Serpa| first5 = Paula Hayakawa| last6 = Detweiler| first6 = Angela M.| last7 = Neff| first7 = Norma| last8 = Pisco| first8 = Angela Oliveira| last9 = Li| first9 = Lucy M.| last10 = Retallack| first10 = Hanna| last11 = Ratnasiri| first11 = Kalani| last12 = Williamson| first12 = Kayla M.| last13 = Soesanto| first13 = Victoria| last14 = Simões| first14 = Eric A. F.| last15 = Smith| first15 = Christiana| last16 = Abuogi| first16 = Lisa| last17 = Kistler| first17 = Amy| last18 = Wagner| first18 = Brandie D.| last19 = DeRisi| first19 = Joseph L.| last20 = Ambroggio| first20 = Lilliam| last21 = Mourani| first21 = Peter M.| last22 = Langelier| first22 = Charles R.| title = Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children| journal = Nature Communications| date = 2022-07-08| pmid = 35803954| pmc = 9263813| bibcode = 2022NatCo..13.3937M}}</ref>

In 2020, early in the [[COVID-19 pandemic]], DeRisi led a team that turned an empty lab space adjacent to the CZ Biohub into a CLIA-certified [[COVID-19]] testing facility in eight days.<ref>{{cite web | date= October 21, 2020 |title= A Model for the Nation: Building a COVID-19 Testing Lab in Only Eight Days | url= https://chanzuckerberg.com/blog/a-model-for-the-nation-building-a-covid-19-testing-lab-in-only-eight-days/ | website= chanzuckerberg.com | access-date= May 1, 2021}}</ref><ref name= "Bloomberg1">{{cite news |last= Lewis |first= Michael |date= April 16, 2020 |title= The Covid Test Lab That Could Save America | url= https://www.bloomberg.com/opinion/articles/2020-04-17/chan-zuckerberg-biohub-is-ready-for-coronavirus-tests-to-come | website= bloomberg.com | access-date= May 1, 2021}}</ref> CLIAhub became one of the nation's leading COVID-19 testing centers, processing thousands of tests per day and becoming a model for the nation.<ref name= "Bloomberg2">{{cite news |last= Lewis |first= Michael |date= May 8, 2020 |title= Armed With Swabs, Covid Hunters Stalk Their Prey | url= https://www.bloomberg.com/opinion/articles/2020-05-08/covid-19-hunters-of-chan-zuckerberg-biohub-stalk-mission-district | website= bloomberg.com | access-date= May 1, 2021}}</ref><ref name= "Bloomberg3">{{cite news |last= Lewis |first= Michael |date= June 21, 2020 |title= The New Weapon in the Covid-19 War| url= https://www.bloomberg.com/graphics/2020-opinion-chan-zuckerberg-biohub-covid-tracing/| website= bloomberg.com | access-date= May 1, 2021}}</ref><ref name= "Bloomberg4">{{cite news |last= Lewis |first= Michael |date= April 7, 2020 |title= In Berkeley, Hunting Toilet Paper and Dodging Hikers| url= https://www.bloomberg.com/opinion/articles/2020-04-08/virus-robs-america-of-toilet-paper-nasal-swabs-and-tom-dempsey| website= bloomberg.com | access-date= May 1, 2021}}</ref> DeRisi’s early warning of the pandemic and development of rapid testing technology was documented by [[Michael Lewis]] in his book ''The Premonition: A Pandemic Story''.<ref>{{Cite news| issn = 0362-4331| last = Confessore| first = Nicholas| title = Michael Lewis Chronicles the Story of Covid's Cassandras| work = The New York Times| accessdate = 2022-11-01| date = 2021-05-06| url = https://www.nytimes.com/2021/05/06/books/review/the-premonition-michael-lewis.html}}</ref><ref>{{Cite news| issn = 0261-3077| last = O’Connell| first = Mark| title = The Premonition by Michael Lewis review – a pandemic story| work = The Guardian| accessdate = 2022-11-01| date = 2021-05-05| url = https://www.theguardian.com/books/2021/may/05/the-premonition-by-michael-lewis-review-a-pandemic-story}}</ref> At the same time, DeRisi became an active proponent of developing a national COVID-19 surveillance system to identify and monitor mutations in the COVID-19 virus.<ref name= "NBCnews">{{cite web |last= Dunn |first= Lauren |date= January 8, 2021 |title= As U.K. variant spreads in U.S., scientists warn that country isn't doing enough to track Covid strains| url= https://www.nbcnews.com/health/health-news/u-k-variant-spreads-u-s-scientists-warn-country-isn-n1253467| website= NBCNews.com| access-date= May 1, 2021}}</ref><ref name= "SFChronicle">{{cite web |last= Allday |first= Erin |date= January 23, 2021 |title= The inside story of how the Bay Area coronavirus variant was discovered| url= https://www.sfchronicle.com/bayarea/article/Bay-Area-scientists-hunting-for-coronavirus-15891829.php| website= sfchronicle.com | access-date= May 1, 2021}}</ref><ref name= "Bloomberg3"/>

== Awards and honors ==
* 2001 Searle Scholar Award, The [[Searle Scholars Program]], Northbrook IL
* 2001 Searle Scholar Award, The [[Searle Scholars Program]], Northbrook IL
* 2001 JP Morgan Chase Health Award, The [[Tech Museum]] of Innovation, San Jose CA
* 2001 JP Morgan Chase Health Award, The [[Tech Museum]] of Innovation, San Jose CA
Line 105: Line 97:
* 2007 Chabot Science Award, [[Chabot Space & Science Center]], Oakland, CA
* 2007 Chabot Science Award, [[Chabot Space & Science Center]], Oakland, CA
* 2008 The 14th Annual [[Heinz Awards|Heinz Award]] for Technology, the Economy and Employment, Pittsburgh, PA
* 2008 The 14th Annual [[Heinz Awards|Heinz Award]] for Technology, the Economy and Employment, Pittsburgh, PA
*2014 The [[John J. Carty Award for the Advancement of Science]] from the [[National Academy of Sciences]]<ref>{{Cite web| title = John J. Carty Award for the Advancement of Science| work = National Academy of Sciences| accessdate = 2022-11-18| date = 2014| url = http://www.nasonline.org/programs/awards/john-j-carty-award.html}}</ref>
*Eli Lilly and Company Research Award Laureate<ref name=UCSFPBBR/>

And '''Membership in scientific organizations''' would contain:

*2013 Elected fellow of the [[California Academy of Sciences]]<ref>{{cite web |date= October 4, 2013 |title= California Academy of Sciences Welcomes New Fellows, Bestows Annual Awards | url= https://www.calacademy.org/press/releases/california-academy-of-sciences-welcomes-new-fellows-bestows-annual-awards| website= calacademy.org | access-date= May 1, 2021}}</ref>
*2013 Elected fellow of the Academy of the American Society of Microbiology.<ref>{{cite web |date= February 16, 2021 |title= 65 Fellows Elected into the American Academy of Microbiology| url= https://asm.org/Press-Releases/2021/February/65-Fellows-Elected-into-the-American-Academy-of-Mi| website= asm.org | access-date= May 1, 2021}}</ref>
*2015 Elected to the [[American Academy of Arts and Sciences]]<ref>{{Cite web| title = Joseph L. DeRisi| work = American Academy of Arts & Sciences| accessdate = 2022-11-18| url = https://www.amacad.org/person/joseph-l-derisi}}</ref>
*2016 Elected as a member of the [[National Academy of Sciences]]<ref>{{citation|url=http://www.nasonline.org/news-and-multimedia/news/may-3-2016-NAS-Election.html|title=National Academy of Sciences Members and Foreign Associates Elected|department=News from the National Academy of Sciences|publisher=[[National Academy of Sciences]]|date=May 3, 2016|accessdate=2016-05-14|archive-url=https://web.archive.org/web/20160506052951/http://www.nasonline.org/news-and-multimedia/news/may-3-2016-NAS-Election.html|archive-date=May 6, 2016|url-status=dead}}.</ref>
*2016 Elected as a member of the [[National Academy of Medicine]]<ref>{{cite web |last= Bai |first= Nina |date= October 17, 2016 |title= 3 UCSF Faculty Elected to the National Academy of Medicine for 2016 | url= https://www.ucsf.edu/news/2016/10/404611/3-ucsf-faculty-elected-national-academy-medicine-2016| website= ucsf.edu | access-date= May 1, 2021}}</ref>


==References==
==References==
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[[Category:University of California, San Francisco faculty]]
[[Category:University of California, San Francisco faculty]]
[[Category:Howard Hughes Medical Investigators]]
[[Category:Howard Hughes Medical Investigators]]
[[Category:Stanford Medical School alumni]]
[[Category:Stanford University School of Medicine alumni]]
[[Category:University of California, Santa Cruz alumni]]
[[Category:University of California, Santa Cruz alumni]]
[[Category:American molecular biologists]]
[[Category:American molecular biologists]]
[[Category:American virologists]]
[[Category:American virologists]]
[[Category:Members of the United States National Academy of Sciences]]
[[Category:Members of the United States National Academy of Sciences]]
[[Category:Fellows of the American Academy of Microbiology]]
[[Category:Members of the National Academy of Medicine]]

Latest revision as of 08:24, 25 April 2024

Joseph DeRisi
NationalityAmerican
Alma materStanford University, University of California, Santa Cruz
Known forViroChip, work on identifying SARS virus, gene expression in Plasmodium falciparum
Scientific career
FieldsBiology
InstitutionsUniversity of California, San Francisco Howard Hughes Medical Institute
ThesisThe Analysis of whole genome gene expression in the budding yeast Saccharomyces cerevisiae. (1999)
Doctoral advisorPatrick O. Brown

Joseph Lyman DeRisi is an American biochemist, specializing in molecular biology, parasitology, genomics, virology, and computational biology.

Early life and education[edit]

DeRisi was raised in Carmichael, California, where he graduated from Del Campo High School.[1] He received a B.A. in Biochemistry and Molecular Biology in 1992 from the University of California, Santa Cruz.[2]

DeRisi earned his Ph.D. in biochemistry from Stanford University in 1999. Working in the laboratory of Patrick O. Brown, he developed methods for the production and use of DNA microarrays in molecular biology, and his thesis was a genome-wide expression analysis of the budding yeast S. cerevisiae.[3][4][5] Upon graduation, DeRisi accepted a position as a Sandler Fellow at the University of California San Francisco.[2][6]

Career and research[edit]

DeRisi has been a faculty member of the UCSF biochemistry and biophysics department since 1999. As of 2022 he is a professor of biochemistry and biophysics and is also the director of UCSF's Sandler Program for Breakthrough Biomedical Research.[2][6]

DeRisi is known for printing the first whole-genome expression array,[7] performing the first broad analysis of differential gene expression in cancer cells,[8] profiling gene expression throughout the lifecycle of the malaria-causing protozoan Plasmodium falciparum,[9] genomic characterization of the SARS-CoV-1 virus,[10] and pioneering virus discovery using gene hybridization arrays and DNA sequencing technologies.[11]

In his early career, DeRisi was a pioneer of microarrays, and designed and built both hardware and software for microarrays. He was a proponent of open access to microarray technology,[5] and maintained a website with software and protocols for microarray operations.[4] He is also a proponent of open access publishing.[12]

In 2002, DeRisi and his research collaborator David Wang developed the ViroChip, a DNA microarray that could be used to rapidly identify viruses in a sample of blood or tissue.[13] He used the tool to help identify the SARS-CoV-1 virus in 2003. In 2004, DeRisi was named a MacArthur fellow for his work with ViroChip and genomic diagnostic techniques.[12][14]

DeRisi became a Howard Hughes Medical Institute (HHMI) investigator in 2005, and received financial support from HHMI for his research.[6][15] He remained an investigator until 2016.[16]

DeRisi and his colleagues employ metagenomic next-generation sequencing (mNGS) for applications including to identify the causal agents in cases of infectious encephalitis and meningitis and to discriminate between autoimmune and infectious causes, diagnosing cases that are difficult to decipher using traditional clinical laboratory techniques.[13][17] Using metagenomic sequencing, DeRisi has identified disease-causing viruses in humans, and in animals ranging from parrots and cockatiels to honeybees and boa constrictors.[13][18] He and a research partner, Don Ganem, have identified a parasite, Nosema ceranae, that appears to be responsible for colony collapse among honeybees.[19] He has also de-bunked the relation of viruses to certain subsets of human cancer.[20]

DeRisi and his colleague Dr. Michael Wilson used a phage display to screen antibody samples from patients with autoimmune symptoms against a library of human proteins, allowing them to identify a cancer-associated autoantigen that is the cause of the symptoms.[20][21]

DeRisi’s lab at UCSF also conducts research to understand the genetics of the malaria-causing pathogen Plasmodium falciparum, the causative agent of the most deadly form of human malaria.[12][22] DeRisi's group has developed candidate drugs to cure malaria.[23] In 2011, the group determined the function of the apicoplast, a unique organelle in apicomplexans, identifying the target of an anti-malarial drug that was a preclinical candidate.[24][25]

In 2016, DeRisi became the co-president of the newly established CZ Biohub, alongside Stephen Quake.[26] After joining CZ Biohub, DeRisi established a team of developers to create a cloud-based metagenomic diagnostic platform based on code from his lab at UCSF. The platform, then named IDSeq, was initially launched for testing by a small group in 2018.[27][17] The development and computing costs were backed by the Chan Zuckerberg Initiative and CZ Biohub.[17] The platform is used to rapidly identify pathogens from metagenomic sequencing data,[28] and as of 2022 is known as CZ-ID.[29]

In 2020, early in the COVID-19 pandemic, DeRisi led a team that turned an empty lab space adjacent to the CZ Biohub into a CLIA-certified COVID-19 testing facility in eight days.[30][31] CLIAhub became one of the nation's leading COVID-19 testing centers, processing thousands of tests per day and becoming a model for the nation.[32][33][34] DeRisi’s early warning of the pandemic and development of rapid testing technology was documented by Michael Lewis in his book The Premonition: A Pandemic Story.[35][36] At the same time, DeRisi became an active proponent of developing a national COVID-19 surveillance system to identify and monitor mutations in the COVID-19 virus.[37][38][33]

Awards and honors[edit]

And Membership in scientific organizations would contain:

References[edit]

  1. ^ "Dr. Joe Derisi". San Juan Education Foundation. Retrieved 2022-10-17.
  2. ^ a b c d "Sandler Program for Breakthrough Biomedical Research: Our Leadership". UCSF Sandler Program for Breakthrough Biomedical Research. Retrieved 2022-10-28.
  3. ^ DeRisi, Joseph L. (1999). The Analysis of whole genome gene expression in the budding yeast Saccharomyces cerevisiae. SearchWorks Stanford (Thesis). OCLC 80580640. Retrieved 2022-10-18.
  4. ^ a b Kahn, Jennifer (2006-12-02). "New Chips on the Block" (PDF). The Economist Technology Quarterly. Retrieved 2022-10-12.
  5. ^ a b Adams, Amy. "PhD alum Joe DeRisi brings innovation to the masses". Stanford Medicine Magazine. Vol. Summer 2002. Retrieved 2022-10-18.
  6. ^ a b c Hopkin, Karen (2005-11-20). "SARS, Malaria, and the Microarray". The Scientist Magazine. Retrieved 2022-10-17.
  7. ^ DeRisi, JL; Iyer, VR; Brown, PO (1997). "Exploring the metabolic and genetic control of gene expression on a genomic scale". Science. 278 (5338): 680–6. Bibcode:1997Sci...278..680D. CiteSeerX 10.1.1.335.7937. doi:10.1126/science.278.5338.680. PMID 9381177.
  8. ^ DeRisi, J; Penland, L; Brown, PO; Bittner, ML; Meltzer, PS; Ray, M; Chen, Y; Su, YA; Trent, JM (1996). "Use of a cDNA microarray to analyse gene expression patterns in human cancer". Nat Genet. 14 (4): 457–60. doi:10.1038/ng1296-457. PMID 8944026. S2CID 23091561.
  9. ^ Llinas, Manuel; Bozdech, Zbynek; Wong, Edith D.; Adai, Alex T.; Derisi, Joseph L. (2006), "Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains", Nucleic Acids Research, 34 (4): 1166–73, doi:10.1093/nar/gkj517, PMC 1380255, PMID 16493140
  10. ^ Rota, Paul A.; Oberste, M. Steven; Monroe, Stephan S.; Nix, W. Allan; Campagnoli, Ray; Icenogle, Joseph P.; Penaranda, Silvia; Bankamp, Bettina; Maher, Kaija; Bellini, William J. (2003), "Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome", Science, 300 (5624): 1394–9, Bibcode:2003Sci...300.1394R, doi:10.1126/science.1085952, PMID 12730500
  11. ^ Wang, D; Coscoy, L; Zylberberg, M; Avila, PC; Boushey, HA; Ganem, D; DeRisi, JL (2002). "Microarray-based detection and genotyping of viral pathogens". Proc Natl Acad Sci U S A. 99 (24): 15687–92. Bibcode:2002PNAS...9915687W. doi:10.1073/pnas.242579699. PMC 137777. PMID 12429852.
  12. ^ a b c Russell, Sabin (2004-09-28). "THE MACARTHUR GRANTS: BAY AREA PROFILES / His quick work on SARS gave crucial answers". SF Gate. Retrieved 2022-10-28.
  13. ^ a b c Kahn, Jennifer (2021-06-03). "The Disease Detective". The New York Times. ISSN 0362-4331. Retrieved 2022-10-12.
  14. ^ "Joseph DeRisi". Macarthur Foundation. Retrieved 2022-11-01.
  15. ^ O'Brien, Jennifer (2005-03-22). "Two UCSF Scientists Named Howard Hughes Medical Institute Investigators | UC San Francisco". UCSF. Retrieved 2022-10-31.
  16. ^ "Joseph L. DeRisi" (Text). HHMI. Retrieved 2022-10-31.
  17. ^ a b c Yong, Ed (2018-10-16). "A Simpler Way to Get to the Bottom of Mysterious Illnesses in Poor Countries". The Atlantic. Retrieved 2022-11-01.
  18. ^ Dubey, Divyanshu; Mandel-Brehm, Caleigh (July 4, 2019). "Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis". The New England Journal of Medicine. 381 (1): 47–54. doi:10.1056/NEJMoa1816721. PMC 6800027. PMID 31269365.
  19. ^ "UCSF Sleuths Identify Suspects in Mystery of Vanishing Honeybees". UCSF.com. 25 April 2007. Retrieved October 28, 2022.
  20. ^ a b Allday, Erin (July 15, 2019). "Rare disease discovery: Antibodies fighting cancer go on to attack brain". sfchronicle.com. Retrieved May 1, 2021.
  21. ^ Mandel-Brehm, Caleigh; Dubey, Divyanshu; Kryzer, Thomas J.; O’Donovan, Brian D.; Tran, Baouyen; Vazquez, Sara E.; Sample, Hannah A.; Zorn, Kelsey C.; Khan, Lillian M.; Bledsoe, Ian O.; McKeon, Andrew; Pleasure, Samuel J.; Lennon, Vanda A.; DeRisi, Joseph L.; Wilson, Michael R.; Pittock, Sean J. (2019-07-04). "Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis". New England Journal of Medicine. 381 (1): 47–54. doi:10.1056/NEJMoa1816721. ISSN 0028-4793. PMC 6800027. PMID 31269365. Retrieved 2022-11-01.
  22. ^ Wade, Nicholas (2003-08-12). "New Chink in the Armor Of the Malaria Parasite". The New York Times. ISSN 0362-4331. Retrieved 2022-11-01.
  23. ^ Jiménez-Díaz, María; Ebert, Daniel (December 1, 2014). "(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium". Proceedings of the National Academy of Sciences of the United States of America. 111 (50): E5455-62. Bibcode:2014PNAS..111E5455J. doi:10.1073/pnas.1414221111. PMC 4273362. PMID 25453091.
  24. ^ Palca, Joe (2011-08-30). "A Remnant From Algae In Malaria Parasite May Prove Its Weakness". NPR. Retrieved 2022-11-01.
  25. ^ Yeh, Ellen; DeRisi, Joseph L. (2011-08-30). "Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum". PLOS Biology. 9 (8): –1001138. doi:10.1371/journal.pbio.1001138. ISSN 1545-7885. PMC 3166167. PMID 21912516.
  26. ^ DeFrancesco, Laura (2020-09-11). "The making of the Biohub". Nature Biotechnology. 38 (10): 1116–1120. doi:10.1038/s41587-020-0685-y. ISSN 1546-1696. PMID 32918057. S2CID 221637469.
  27. ^ Molteni, Megan (2020-03-10). "A Disease Tracker Backed by Gates and Zuckerberg Tackles Covid-19". Wired. ISSN 1059-1028. Retrieved 2022-11-01.
  28. ^ Kalantar, Katrina L; Carvalho, Tiago; de Bourcy, Charles F A; Dimitrov, Boris; Dingle, Greg; Egger, Rebecca; Han, Julie; Holmes, Olivia B; Juan, Yun-Fang; King, Ryan; Kislyuk, Andrey (October 2020). "IDseq—An open source cloud-based pipeline and analysis service for metagenomic pathogen detection and monitoring". GigaScience. 9 (10). doi:10.1093/gigascience/giaa111. ISSN 2047-217X. PMC 7566497. PMID 33057676.
  29. ^ Mick, Eran; Tsitsiklis, Alexandra; Spottiswoode, Natasha; Caldera, Saharai; Serpa, Paula Hayakawa; Detweiler, Angela M.; Neff, Norma; Pisco, Angela Oliveira; Li, Lucy M.; Retallack, Hanna; Ratnasiri, Kalani; Williamson, Kayla M.; Soesanto, Victoria; Simões, Eric A. F.; Smith, Christiana; Abuogi, Lisa; Kistler, Amy; Wagner, Brandie D.; DeRisi, Joseph L.; Ambroggio, Lilliam; Mourani, Peter M.; Langelier, Charles R. (2022-07-08). "Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children". Nature Communications. 13 (1): 3937. Bibcode:2022NatCo..13.3937M. doi:10.1038/s41467-022-31600-0. ISSN 2041-1723. PMC 9263813. PMID 35803954.
  30. ^ "A Model for the Nation: Building a COVID-19 Testing Lab in Only Eight Days". chanzuckerberg.com. October 21, 2020. Retrieved May 1, 2021.
  31. ^ Lewis, Michael (April 16, 2020). "The Covid Test Lab That Could Save America". bloomberg.com. Retrieved May 1, 2021.
  32. ^ Lewis, Michael (May 8, 2020). "Armed With Swabs, Covid Hunters Stalk Their Prey". bloomberg.com. Retrieved May 1, 2021.
  33. ^ a b Lewis, Michael (June 21, 2020). "The New Weapon in the Covid-19 War". bloomberg.com. Retrieved May 1, 2021.
  34. ^ Lewis, Michael (April 7, 2020). "In Berkeley, Hunting Toilet Paper and Dodging Hikers". bloomberg.com. Retrieved May 1, 2021.
  35. ^ Confessore, Nicholas (2021-05-06). "Michael Lewis Chronicles the Story of Covid's Cassandras". The New York Times. ISSN 0362-4331. Retrieved 2022-11-01.
  36. ^ O’Connell, Mark (2021-05-05). "The Premonition by Michael Lewis review – a pandemic story". The Guardian. ISSN 0261-3077. Retrieved 2022-11-01.
  37. ^ Dunn, Lauren (January 8, 2021). "As U.K. variant spreads in U.S., scientists warn that country isn't doing enough to track Covid strains". NBCNews.com. Retrieved May 1, 2021.
  38. ^ Allday, Erin (January 23, 2021). "The inside story of how the Bay Area coronavirus variant was discovered". sfchronicle.com. Retrieved May 1, 2021.
  39. ^ "John J. Carty Award for the Advancement of Science". National Academy of Sciences. 2014. Retrieved 2022-11-18.
  40. ^ "California Academy of Sciences Welcomes New Fellows, Bestows Annual Awards". calacademy.org. October 4, 2013. Retrieved May 1, 2021.
  41. ^ "65 Fellows Elected into the American Academy of Microbiology". asm.org. February 16, 2021. Retrieved May 1, 2021.
  42. ^ "Joseph L. DeRisi". American Academy of Arts & Sciences. Retrieved 2022-11-18.
  43. ^ National Academy of Sciences Members and Foreign Associates Elected, News from the National Academy of Sciences, National Academy of Sciences, May 3, 2016, archived from the original on May 6, 2016, retrieved 2016-05-14.
  44. ^ Bai, Nina (October 17, 2016). "3 UCSF Faculty Elected to the National Academy of Medicine for 2016". ucsf.edu. Retrieved May 1, 2021.

External links[edit]