SLC22A4: Difference between revisions
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| summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A4 solute carrier family 22 (organic cation transporter), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6583| accessdate = }}</ref> |
| summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A4 solute carrier family 22 (organic cation transporter), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6583| accessdate = }}</ref> This transporter is responsible for the transport of [[ergothioneine]], which is an [[antioxidant]] [[amino acid]], into cells.<ref>{{cite journal | author=Gründemann D, Harlfinger S, Golz S, ''et al.'' |title=Discovery of the ergothioneine transporter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 14 |pages= 5256–61 |year= 2005 |pmid= 15795384 |doi= 10.1073/pnas.0408624102 }}</ref> |
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*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }} |
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }} |
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*{{cite journal | author=Newman B, Gu X, Wintle R, ''et al.'' |title=A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease. |journal=Gastroenterology |volume=128 |issue= 2 |pages= 260–9 |year= 2005 |pmid= 15685536 |doi= }} |
*{{cite journal | author=Newman B, Gu X, Wintle R, ''et al.'' |title=A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease. |journal=Gastroenterology |volume=128 |issue= 2 |pages= 260–9 |year= 2005 |pmid= 15685536 |doi= }} |
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*{{cite journal | author=Gründemann D, Harlfinger S, Golz S, ''et al.'' |title=Discovery of the ergothioneine transporter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 14 |pages= 5256–61 |year= 2005 |pmid= 15795384 |doi= 10.1073/pnas.0408624102 }} |
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Revision as of 20:17, 1 April 2009
Template:PBB Solute carrier family 22 (organic cation transporter), member 4, also known as SLC22A4, is a human gene.[1]
See also
References
Further reading
 | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.