Monocarboxylate transporter 10: Difference between revisions

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{{PBB|geneid=117247}}
{{protein
'''Monocarboxylate transporter 10''' (MCT 10), also known as '''aromatic amino acid transporter 1''' and '''T-type amino acid transporter 1''' (TAT1) and '''solute carrier family 16 member 10''' (SLC16A10), is a [[protein]] that in humans is encoded by the ''SLC16A10'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: solute carrier family 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117247| accessdate = }}</ref><ref name="pmid11278508">{{cite journal | author = Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H | title = Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17221–8 | year = 2001 | month = May | pmid = 11278508 | doi = 10.1074/jbc.M009462200 | url = | issn = }}</ref><ref name="pmid11827462">{{cite journal | author = Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H | title = The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location | journal = Genomics | volume = 79 | issue = 1 | pages = 95–103 | year = 2002 | month = January | pmid = 11827462 | doi = 10.1006/geno.2001.6678 | url = | issn = }}</ref> SLC16A10 is a member of the [[solute carrier family]].
|name=solute carrier family 16, member 10 (aromatic amino acid transporter)

|caption=
== Function ==
|image=

|width=
SLC16A10 mediates [[sodium|Na<sup>+</sup>]]-independent transport of [[tryptophan]], [[tyrosine]], [[phenylalanine]], and [[L-DOPA]].<ref name="pmid11827462">{{cite journal | author = Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H | title = The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location | journal = Genomics | volume = 79 | issue = 1 | pages = 95–103 | year = 2002 | month = January | pmid = 11827462 | doi = 10.1006/geno.2001.6678 | url = | issn = }}</ref>
|HGNCid=17027
|Symbol=SLC16A10
|AltSymbols=
|EntrezGene=117247
|OMIM=607550
|RefSeq=
|UniProt=
|PDB=
|ECnumber=
|Chromosome=6
|Arm=q
|Band=21
|LocusSupplementaryData=-q22
}}
'''SLC16A10''' is a member of the [[solute carrier family]].


==See also==
==See also==
* [[Blue diaper syndrome]]
* [[Blue diaper syndrome]]


==References==
⚫
{{Genetics-stub}}
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal |author=Toure A, Morin L, Pineau C, ''et al.'' |title=Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20309-15 |year= 2001 |pmid= 11278976 |doi= 10.1074/jbc.M011740200 }}
*{{cite journal |author=Friesema EC, Jansen J, Jachtenberg JW, ''et al.'' |title=Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10. |journal=Mol. Endocrinol. |volume=22 |issue= 6 |pages= 1357-69 |year= 2008 |pmid= 18337592 |doi= 10.1210/me.2007-0112 }}
*{{cite journal |author=Loubière LS, Vasilopoulou E, Bulmer JN, ''et al.'' |title=Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction. |journal=Placenta |volume=31 |issue= 4 |pages= 295-304 |year= 2010 |pmid= 20167367 |doi= 10.1016/j.placenta.2010.01.013 }}
*{{cite journal |author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |author=Bröer S |title=Amino acid transport across mammalian intestinal and renal epithelia. |journal=Physiol. Rev. |volume=88 |issue= 1 |pages= 249-86 |year= 2008 |pmid= 18195088 |doi= 10.1152/physrev.00018.2006 }}
*{{cite journal |author=Park SY, Kim JK, Kim IJ, ''et al.'' |title=Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. |journal=Arch. Pharm. Res. |volume=28 |issue= 4 |pages= 421-32 |year= 2005 |pmid= 15918515 |doi= }}
*{{cite journal |author=Halestrap AP, Meredith D |title=The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. |journal=Pflugers Arch. |volume=447 |issue= 5 |pages= 619-28 |year= 2004 |pmid= 12739169 |doi= 10.1007/s00424-003-1067-2 }}
{{refend}}

⚫
{{gene-6-stub}}
{{solute carrier family}}
{{solute carrier family}}

Revision as of 18:46, 25 December 2010

Template:PBB Monocarboxylate transporter 10 (MCT 10), also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene.[1][2][3] SLC16A10 is a member of the solute carrier family.

Function

SLC16A10 mediates Na+-independent transport of tryptophan, tyrosine, phenylalanine, and L-DOPA.[3]

See also

References

  1. ^ "Entrez Gene: solute carrier family 16".
  2. ^ Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H (2001). "Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters". J. Biol. Chem. 276 (20): 17221–8. doi:10.1074/jbc.M009462200. PMID 11278508. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  3. ^ a b Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H (2002). "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location". Genomics. 79 (1): 95–103. doi:10.1006/geno.2001.6678. PMID 11827462. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Further reading

  • Toure A, Morin L, Pineau C; et al. (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Friesema EC, Jansen J, Jachtenberg JW; et al. (2008). "Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10". Mol. Endocrinol. 22 (6): 1357–69. doi:10.1210/me.2007-0112. PMID 18337592. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Loubière LS, Vasilopoulou E, Bulmer JN; et al. (2010). "Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction". Placenta. 31 (4): 295–304. doi:10.1016/j.placenta.2010.01.013. PMID 20167367. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
  • Park SY, Kim JK, Kim IJ; et al. (2005). "Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule". Arch. Pharm. Res. 28 (4): 421–32. PMID 15918515. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflugers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.
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