Electrogenic sodium bicarbonate cotransporter 4: Difference between revisions
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'''Electrogenic sodium bicarbonate cotransporter 4''' is a [[protein]] that in humans is encoded by the ''SLC4A5'' [[gene]].<ref name="pmid10978526">{{cite journal | author = Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I | title = Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family | journal = Biochim Biophys Acta | volume = 1493 | issue = 1–2 | pages = 215–8 | year = 2000 | month = Nov | pmid = 10978526 | pmc = | doi = }}</ref><ref name="pmid11087115">{{cite journal | author = Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I | title = Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization | journal = IUBMB Life | volume = 50 | issue = 1 | pages = 13–9 | year = 2001 | month = Mar | pmid = 11087115 | pmc = | doi = 10.1080/15216540050176539 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC4A5 solute carrier family 4, sodium bicarbonate [[cotransporter]], member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57835| accessdate = }}</ref> |
'''Electrogenic sodium bicarbonate cotransporter 4''' is a [[protein]] that in humans is encoded by the ''SLC4A5'' [[gene]].<ref name="pmid10978526">{{cite journal | author = Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I | title = Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family | journal = Biochim Biophys Acta | volume = 1493 | issue = 1–2 | pages = 215–8 | year = 2000 | month = Nov | pmid = 10978526 | pmc = | doi =10.1016/S0167-4781(00)00149-4 }}</ref><ref name="pmid11087115">{{cite journal | author = Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I | title = Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization | journal = IUBMB Life | volume = 50 | issue = 1 | pages = 13–9 | year = 2001 | month = Mar | pmid = 11087115 | pmc = | doi = 10.1080/15216540050176539 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC4A5 solute carrier family 4, sodium bicarbonate [[cotransporter]], member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57835| accessdate = }}</ref> |
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== Function == |
== Function == |
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Revision as of 04:41, 12 April 2013
Template:PBB Electrogenic sodium bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene.[1][2][3]
Function
This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[3]
Clinical significance
This human gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status.[4]
See also
- SLC4A5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
References
- ^ Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I (2000). "Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family". Biochim Biophys Acta. 1493 (1–2): 215–8. doi:10.1016/S0167-4781(00)00149-4. PMID 10978526.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I (2001). "Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization". IUBMB Life. 50 (1): 13–9. doi:10.1080/15216540050176539. PMID 11087115.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b "Entrez Gene: SLC4A5 solute carrier family 4, sodium bicarbonate [[cotransporter]], member 5".
{{cite web}}: URL–wikilink conflict (help) Cite error: The named reference "entrez" was defined multiple times with different content (see the help page). - ^ Gröger N, Vitzthum H, Fröhlich H, Krüger M, Ehmke H, Braun T, Boettger T (2012). "Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis". Hum. Mol. Genet. 21 (5): 1025–36. doi:10.1093/hmg/ddr533. PMID 22082831.
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Further reading
- Soleimani M, Burnham CE (2002). "Na+:HCO(3-) cotransporters (NBC): cloning and characterization". J. Membr. Biol. 183 (2): 71–84. doi:10.1007/s00232-001-0055-8. PMID 11562789.
- Hunt SC; Xin Y; Wu LL; et al. (2006). "Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures". Hypertension. 47 (3): 532–6. doi:10.1161/01.HYP.0000196949.26088.3c. PMID 16365189.
{{cite journal}}: Unknown parameter|author-separator=ignored (help) - Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Unknown parameter|author-separator=ignored (help) - Xu J; Wang Z; Barone S; et al. (2003). "Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant". Am. J. Physiol. Renal Physiol. 284 (1): F41–50. doi:10.1152/ajprenal.00055.2002. PMID 12388414.
{{cite journal}}: Unknown parameter|author-separator=ignored (help); Unknown parameter|doi_brokendate=ignored (|doi-broken-date=suggested) (help) - Pushkin A; Abuladze N; Newman D; et al. (2002). "Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued)". Cytogenet. Cell Genet. 95 (3–4): 163–8. doi:10.1159/000059340. PMID 12063394.
{{cite journal}}: Unknown parameter|author-separator=ignored (help) - Sassani P; Pushkin A; Gross E; et al. (2002). [10.1152/ajpcell.00409.2001 "Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter"]. Am. J. Physiol., Cell Physiol. 282 (2): C408–16. doi:10.1152/ajpcell.00409.2001. PMID 11788353.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.