Antiprogestogen: Difference between revisions
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'''Antiprogestogens''', or '''antiprogestins''', also known as '''progesterone antagonists''' or '''progesterone blockers''', are a class of [[drug]]s which prevent [[progestogen]]s like [[progesterone]] from mediating their [[biological effect]]s in the body. They act by [[receptor antagonist|blocking]] the [[progesterone receptor]] (ER) and/or [[steroidogenesis inhibitor|inhibiting]] or [[antigonadotropin|suppressing]] progestogen [[biosynthesis|production]]. Antiprogestogens are one of three types of [[sex hormone]] [[hormone antagonist|antagonist]]s, the others being [[antiestrogen]]s and [[antiandrogen]]s.<ref name="Nath2006">{{cite book|author=Judi Lindsley Nath|title=Using Medical Terminology: A Practical Approach|url=https://books.google.com/books?id=UEvTZg_5FBIC&pg=PA977|year=2006|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-4868-1|pages=977–}}</ref> |
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An '''antiprogestogen''', also called an '''antiprogesterone agent''', or in the case of a [[Organic compound#Synthetic compounds|synthetic]] compound, an '''antiprogestin''', is a type of [[hormone antagonist]] which antagonizes or suppresses the action of the [[progestogen]] [[progesterone]] in the body, a [[sex hormone]] that plays a [[role]] in the [[menstrual cycle]] and [[pregnancy]]. Antiprogestogens may stop some [[cancer cells]] from [[Cell growth|growing]] and they are being studied in the treatment of [[breast cancer]]. They are also used as [[abortifacient]]s. |
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Examples of antiprogestogens include [[ |
Antiprogestogens are used as [[abortifacient]]s and [[emergency contraception|emergency contraceptive]]s and in the treatment of [[uterine fibroid]]s. They are also being studied in the treatment of [[breast cancer]]. Examples of antiprogestogens include the [[progesterone receptor]] weak [[partial agonist]] [[mifepristone]], the [[selective progesterone receptor modulator]] (SPRM) [[ulipristal acetate]], and the [[silent antagonist]] [[aglepristone]].<ref name="Spitz-2006">{{Cite journal | last1 = Spitz | first1 = IM. | title = Progesterone receptor antagonists. | journal = Curr Opin Investig Drugs | volume = 7 | issue = 10 | pages = 882–90 |date=Oct 2006 | doi = | PMID = 17086932 }}</ref><ref name="Tang-2006">{{Cite journal | last1 = Tang | first1 = OS. | last2 = Ho | first2 = PC. | title = Clinical applications of mifepristone. | journal = Gynecol Endocrinol | volume = 22 | issue = 12 | pages = 655–9 |date=Dec 2006 | doi = 10.1080/09513590601005946 | PMID = 17162706 }}</ref> For [[medical abortion]], mifepristone is combined with a [[prostaglandin]] (e.g., [[gemeprost]]). |
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Medical termination of pregnancy: mifepristone combined with a [[prostaglandin]] (e.g., [[gemeprost]]). |
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==See also== |
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* [[Selective progesterone receptor modulator]] |
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* [[Antiestrogen]] |
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* [[Selective estrogen receptor modulator]] |
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* [[Antiandrogen]] |
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==References== |
==References== |
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{{Progestogens and antiprogestogens}} |
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{{Antiprogestogens}} |
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{{Progesterone receptor modulators}} |
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{{Progestogenics}} |
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[[Category:Antineoplastic drugs]] |
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[[Category:Antiprogestogens]] |
[[Category:Antiprogestogens]] |
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Revision as of 13:45, 1 January 2017
| Antiprogestogen | |
|---|---|
| Drug class | |
 Mifepristone, an antiprogestin that is used to induce medical abortions. | |
| Class identifiers | |
| Synonyms | Antiprogestins; Progesterone antagonists; Progesterone blockers |
| Use | Medical abortion, emergency contraception, uterine fibroids |
| ATC code | G03XB |
| Biological target | Progesterone receptor |
| Chemical class | Steroidal |
| Legal status | |
| In Wikidata | |
Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs which prevent progestogens like progesterone from mediating their biological effects in the body. They act by blocking the progesterone receptor (ER) and/or inhibiting or suppressing progestogen production. Antiprogestogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiandrogens.[1]
Antiprogestogens are used as abortifacients and emergency contraceptives and in the treatment of uterine fibroids. They are also being studied in the treatment of breast cancer. Examples of antiprogestogens include the progesterone receptor weak partial agonist mifepristone, the selective progesterone receptor modulator (SPRM) ulipristal acetate, and the silent antagonist aglepristone.[2][3] For medical abortion, mifepristone is combined with a prostaglandin (e.g., gemeprost).
References
- ^ Judi Lindsley Nath (2006). Using Medical Terminology: A Practical Approach. Lippincott Williams & Wilkins. pp. 977–. ISBN 978-0-7817-4868-1.
- ^ Spitz, IM. (Oct 2006). "Progesterone receptor antagonists". Curr Opin Investig Drugs. 7 (10): 882–90. PMID 17086932.
- ^ Tang, OS.; Ho, PC. (Dec 2006). "Clinical applications of mifepristone". Gynecol Endocrinol. 22 (12): 655–9. doi:10.1080/09513590601005946. PMID 17162706.
External links
- Antiprogestin entry in the public domain NCI Dictionary of Cancer Terms
This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.
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