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'''Neuropathy target esterase''' also known as '''patatin-like phospholipase domain-containing protein 6''' (PNPLA6) is a neuropathy target esterase [[enzyme]] that in humans is encoded by the ''PNPLA6'' [[gene]].<ref name="pmid9576844">{{cite journal |vauthors=Lush MJ, Li Y, Read DJ, Willis AC, Glynn P | title = Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man | series = 332 | journal = Biochem J | volume = ( Pt 1) | issue = | pages = 1–4 |date=Aug 1998 | pmid = 9576844 | pmc = 1219444 | doi = }}</ref><ref name="pmid16799181">{{cite journal |vauthors=Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ | title = Characterization of the human patatin-like phospholipase family | journal = J Lipid Res | volume = 47 | issue = 9 | pages = 1940–9 |date=Aug 2006 | pmid = 16799181 | pmc = | doi = 10.1194/jlr.M600185-JLR200 }}</ref><ref name="pmid19029121">{{cite journal |vauthors=Kienesberger PC, Oberer M, Lass A, Zechner R | title = Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions | journal = J Lipid Res | volume = 50 Suppl | issue = Supplement| pages = S63–8 |date=Apr 2009 | pmid = 19029121 | pmc = 2674697 | doi = 10.1194/jlr.R800082-JLR200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PNPLA6 patatin-like phospholipase domain containing 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10908| accessdate = }}</ref> |
'''Neuropathy target esterase''' also known as '''patatin-like phospholipase domain-containing protein 6''' (PNPLA6) is a neuropathy target esterase [[enzyme]] that in humans is encoded by the ''PNPLA6'' [[gene]].<ref name="pmid9576844">{{cite journal |vauthors=Lush MJ, Li Y, Read DJ, Willis AC, Glynn P | title = Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man | series = 332 | journal = Biochem J | volume = ( Pt 1) | issue = | pages = 1–4 |date=Aug 1998 | pmid = 9576844 | pmc = 1219444 | doi = 10.1042/bj3320001}}</ref><ref name="pmid16799181">{{cite journal |vauthors=Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ | title = Characterization of the human patatin-like phospholipase family | journal = J Lipid Res | volume = 47 | issue = 9 | pages = 1940–9 |date=Aug 2006 | pmid = 16799181 | pmc = | doi = 10.1194/jlr.M600185-JLR200 }}</ref><ref name="pmid19029121">{{cite journal |vauthors=Kienesberger PC, Oberer M, Lass A, Zechner R | title = Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions | journal = J Lipid Res | volume = 50 Suppl | issue = Supplement| pages = S63–8 |date=Apr 2009 | pmid = 19029121 | pmc = 2674697 | doi = 10.1194/jlr.R800082-JLR200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PNPLA6 patatin-like phospholipase domain containing 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10908| accessdate = }}</ref> |
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Neuropathy target esterase is a phospholipase that deacetylates intracellular phosphatidylcholine to produce [[glycerophosphocholine]]. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells.<ref name="entrez"/> |
Neuropathy target esterase is a phospholipase that deacetylates intracellular phosphatidylcholine to produce [[glycerophosphocholine]]. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells.<ref name="entrez"/> |
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Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents.<ref name="entrez"/> |
Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents.<ref name="entrez"/> |
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Recessively-inherited mutations in ''NTE'' that substantially reduce its catalytic activity cause a rare form of [[hereditary spastic paraplegia]] (SPG39), in which distal parts of long spinal [[axons]] degenerate leading to limb weakness and paralysis.<ref name="pmid18313024">{{cite journal |vauthors=Rainier S, Bui M, Mark E, Thomas D, Tokarz D, Ming L, Delaney C, Richardson RJ, Albers JW, Matsunami N, Stevens J, Coon H, Leppert M, Fink JK | title = Neuropathy target esterase gene mutations cause motor neuron disease | journal = Am. J. Hum. Genet. | volume = 82 | issue = 3 | pages = 780–5 |date=March 2008 | pmid = 18313024 | pmc = 2427280 | doi = 10.1016/j.ajhg.2007.12.018 }}</ref><ref name="pmid21171093">{{cite journal |vauthors=Rainier S, Albers JW, Dyck PJ, Eldevik OP, Wilcock S, Richardson RJ, Fink JK | title = Motor neuron disease due to neuropathy target esterase gene mutation: clinical features of the index families | journal = Muscle Nerve | volume = 43 | issue = 1 | pages = 19–25 |date=January 2011 | pmid = 21171093 | doi = 10.1002/mus.21777 }}</ref> [[Organophosphate-induced delayed neuropathy]]{{mdash}} a paralysing syndrome with distal degeneration of long axons{{mdash}} results from poisoning with neuropathic organophosphorus compounds that irreversibly inhibit NTE.<ref name="pmid16042503">{{cite journal |vauthors=Lotti M, Moretto A | title = Organophosphate-induced delayed polyneuropathy | journal = Toxicol Rev | volume = 24 | issue = 1 | pages = 37–49 | year = 2005 | pmid = 16042503 | doi = 10.2165/00139709-200524010-00003| url = }}</ref><ref name="pmid13192490">{{cite journal | author = CAVANAGH JB | title = The toxic effects of triortho-cresyl phosphate on the nervous system; an experimental study in hens | journal = J. Neurol. Neurosurg. Psychiatry | volume = 17 | issue = 3 | pages = 163–72 |date=August 1954 | pmid = 13192490 | pmc = 503178 | doi = 10.1136/jnnp.17.3.163}}</ref><ref name="pmid13877086">{{cite journal |vauthors=CASIDA JE, ETO M, BARON RL | title = Biological activity of a trio-cresyl phosphate metabolite | journal = Nature | volume = 191 | issue = 4796| pages = 1396–7 |date=September 1961 | pmid = 13877086 | doi =10.1038/1911396a0 | url = }}</ref><ref name="pmid4310054">{{cite journal | author = Johnson MK | title = The delayed neurotoxic effect of some organophosphorus compounds. Identification of the phosphorylation site as an esterase | journal = Biochem. J. | volume = 114 | issue = 4 | pages = 711–7 |date=October 1969 | pmid = 4310054 | pmc = 1184957 | doi = 10.1042/bj1140711}}</ref><ref name="pmid8043002">{{cite journal |vauthors=Glynn P, Read DJ, Guo R, Wylie S, Johnson MK | title = Synthesis and characterization of a biotinylated organophosphorus ester for detection and affinity purification of a brain serine esterase: neuropathy target esterase | journal = Biochem. J. | volume = 301 ( Pt 2) | issue = | pages = 551–6 |date=July 1994 | pmid = 8043002 | pmc = 1137116 | doi = }}</ref><ref name="pmid20188121">{{cite journal |vauthors=Read DJ, Li Y, Chao MV, Cavanagh JB, Glynn P | title = Organophosphates induce distal axonal damage, but not brain oedema, by inactivating neuropathy target esterase | journal = Toxicol. Appl. Pharmacol. | volume = 245 | issue = 1 | pages = 108–15 |date=May 2010 | pmid = 20188121 | doi = 10.1016/j.taap.2010.02.010 }}</ref> |
Recessively-inherited mutations in ''NTE'' that substantially reduce its catalytic activity cause a rare form of [[hereditary spastic paraplegia]] (SPG39), in which distal parts of long spinal [[axons]] degenerate leading to limb weakness and paralysis.<ref name="pmid18313024">{{cite journal |vauthors=Rainier S, Bui M, Mark E, Thomas D, Tokarz D, Ming L, Delaney C, Richardson RJ, Albers JW, Matsunami N, Stevens J, Coon H, Leppert M, Fink JK | title = Neuropathy target esterase gene mutations cause motor neuron disease | journal = Am. J. Hum. Genet. | volume = 82 | issue = 3 | pages = 780–5 |date=March 2008 | pmid = 18313024 | pmc = 2427280 | doi = 10.1016/j.ajhg.2007.12.018 }}</ref><ref name="pmid21171093">{{cite journal |vauthors=Rainier S, Albers JW, Dyck PJ, Eldevik OP, Wilcock S, Richardson RJ, Fink JK | title = Motor neuron disease due to neuropathy target esterase gene mutation: clinical features of the index families | journal = Muscle Nerve | volume = 43 | issue = 1 | pages = 19–25 |date=January 2011 | pmid = 21171093 | doi = 10.1002/mus.21777 | hdl = 2027.42/78477 }}</ref> [[Organophosphate-induced delayed neuropathy]]{{mdash}} a paralysing syndrome with distal degeneration of long axons{{mdash}} results from poisoning with neuropathic organophosphorus compounds that irreversibly inhibit NTE.<ref name="pmid16042503">{{cite journal |vauthors=Lotti M, Moretto A | title = Organophosphate-induced delayed polyneuropathy | journal = Toxicol Rev | volume = 24 | issue = 1 | pages = 37–49 | year = 2005 | pmid = 16042503 | doi = 10.2165/00139709-200524010-00003| url = }}</ref><ref name="pmid13192490">{{cite journal | author = CAVANAGH JB | title = The toxic effects of triortho-cresyl phosphate on the nervous system; an experimental study in hens | journal = J. Neurol. Neurosurg. Psychiatry | volume = 17 | issue = 3 | pages = 163–72 |date=August 1954 | pmid = 13192490 | pmc = 503178 | doi = 10.1136/jnnp.17.3.163}}</ref><ref name="pmid13877086">{{cite journal |vauthors=CASIDA JE, ETO M, BARON RL | title = Biological activity of a trio-cresyl phosphate metabolite | journal = Nature | volume = 191 | issue = 4796| pages = 1396–7 |date=September 1961 | pmid = 13877086 | doi =10.1038/1911396a0 | url = }}</ref><ref name="pmid4310054">{{cite journal | author = Johnson MK | title = The delayed neurotoxic effect of some organophosphorus compounds. Identification of the phosphorylation site as an esterase | journal = Biochem. J. | volume = 114 | issue = 4 | pages = 711–7 |date=October 1969 | pmid = 4310054 | pmc = 1184957 | doi = 10.1042/bj1140711}}</ref><ref name="pmid8043002">{{cite journal |vauthors=Glynn P, Read DJ, Guo R, Wylie S, Johnson MK | title = Synthesis and characterization of a biotinylated organophosphorus ester for detection and affinity purification of a brain serine esterase: neuropathy target esterase | journal = Biochem. J. | volume = 301 ( Pt 2) | issue = 2| pages = 551–6 |date=July 1994 | pmid = 8043002 | pmc = 1137116 | doi = 10.1042/bj3010551}}</ref><ref name="pmid20188121">{{cite journal |vauthors=Read DJ, Li Y, Chao MV, Cavanagh JB, Glynn P | title = Organophosphates induce distal axonal damage, but not brain oedema, by inactivating neuropathy target esterase | journal = Toxicol. Appl. Pharmacol. | volume = 245 | issue = 1 | pages = 108–15 |date=May 2010 | pmid = 20188121 | doi = 10.1016/j.taap.2010.02.010 }}</ref> |
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==References== |
==References== |
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*{{cite journal |vauthors=Maroni M, Bleecker ML |title=Neuropathy target esterase in human lymphocytes and platelets. |journal=Journal of Applied Toxicology : JAT |volume=6 |issue= 1 |pages= 1–7 |year= 1986 |pmid= 3958422 |doi=10.1002/jat.2550060102 }} |
*{{cite journal |vauthors=Maroni M, Bleecker ML |title=Neuropathy target esterase in human lymphocytes and platelets. |journal=Journal of Applied Toxicology : JAT |volume=6 |issue= 1 |pages= 1–7 |year= 1986 |pmid= 3958422 |doi=10.1002/jat.2550060102 }} |
||
*{{cite journal |vauthors=Bertoncin D, Russolo A, Caroldi S, Lotti M |title=Neuropathy target esterase in human lymphocytes. |journal=Arch. Environ. Health |volume=40 |issue= 3 |pages= 139–44 |year= 1985 |pmid= 4026382 |doi= 10.1080/00039896.1985.10545905}} |
*{{cite journal |vauthors=Bertoncin D, Russolo A, Caroldi S, Lotti M |title=Neuropathy target esterase in human lymphocytes. |journal=Arch. Environ. Health |volume=40 |issue= 3 |pages= 139–44 |year= 1985 |pmid= 4026382 |doi= 10.1080/00039896.1985.10545905}} |
||
*{{cite journal |vauthors=Gurba PE, Richardson RJ |title=Partial characterization of neurotoxic esterase of human placenta. |journal=Toxicol. Lett. |volume=15 |issue= 1 |pages= 13–7 |year= 1983 |pmid= 6836585 |doi=10.1016/0378-4274(83)90162-5 |url=https://deepblue.lib.umich.edu/bitstream/2027.42/25337/1/0000783.pdf }} |
*{{cite journal |vauthors=Gurba PE, Richardson RJ |title=Partial characterization of neurotoxic esterase of human placenta. |journal=Toxicol. Lett. |volume=15 |issue= 1 |pages= 13–7 |year= 1983 |pmid= 6836585 |doi=10.1016/0378-4274(83)90162-5 |url=https://deepblue.lib.umich.edu/bitstream/2027.42/25337/1/0000783.pdf |hdl=2027.42/25337 }} |
||
*{{cite journal |vauthors=van Tienhoven M, Atkins J, Li Y, Glynn P |title=Human neuropathy target esterase catalyzes hydrolysis of membrane lipids. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20942–8 |year= 2002 |pmid= 11927584 |doi= 10.1074/jbc.M200330200 }} |
*{{cite journal |vauthors=van Tienhoven M, Atkins J, Li Y, Glynn P |title=Human neuropathy target esterase catalyzes hydrolysis of membrane lipids. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20942–8 |year= 2002 |pmid= 11927584 |doi= 10.1074/jbc.M200330200 }} |
||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} |
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} |
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Revision as of 21:35, 13 December 2019
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| Identifiers | |||||||||||||||||||||||||||||||
| Aliases | PNPLA6, BNHS, NTE, NTEMND, SPG39, iPLA2delta, sws, LNMS, OMCS, patatin like phospholipase domain containing 6 | ||||||||||||||||||||||||||||||
| External IDs | OMIM: 603197; MGI: 1354723; HomoloGene: 21333; GeneCards: PNPLA6; OMA:PNPLA6 - orthologs | ||||||||||||||||||||||||||||||
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Neuropathy target esterase also known as patatin-like phospholipase domain-containing protein 6 (PNPLA6) is a neuropathy target esterase enzyme that in humans is encoded by the PNPLA6 gene.[5][6][7][8]
Neuropathy target esterase is a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells.[8]
Function
Neuropathy target esterase is an enzyme with phospholipase B activity: It sequentially hydrolyses both fatty acids from the major membrane lipid phosphatidylcholine, which generates water-soluble glycerophosphocholine.[9][10] In cells of eukaryotes from yeast to humans, NTE is anchored to the cytoplasmic face of the endoplasmic reticulum membrane and is particularly abundant in neurons, the placenta, and the kidney.[11][12][13][14][15] Loss of NTE activity results in abnormally elevated levels of phosphatidylcholine in brain and impairment of the constitutive secretory pathway in neurons.[5][16][17]
In kidney, the expression of neuropathy target esterase is regulated by TonEBP as part of osmolyte production when a concentrated urine is produced.[18]
Clinical significance
Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents.[8]
Recessively-inherited mutations in NTE that substantially reduce its catalytic activity cause a rare form of hereditary spastic paraplegia (SPG39), in which distal parts of long spinal axons degenerate leading to limb weakness and paralysis.[19][20] Organophosphate-induced delayed neuropathy— a paralysing syndrome with distal degeneration of long axons— results from poisoning with neuropathic organophosphorus compounds that irreversibly inhibit NTE.[21][22][23][24][25][26]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000032444 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004565 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Lush MJ, Li Y, Read DJ, Willis AC, Glynn P (Aug 1998). "Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man". Biochem J. 332. ( Pt 1): 1–4. doi:10.1042/bj3320001. PMC 1219444. PMID 9576844.
- ^ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family". J Lipid Res. 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ a b c "Entrez Gene: PNPLA6 patatin-like phospholipase domain containing 6".
- ^ Glynn P (September 2005). "Neuropathy target esterase and phospholipid deacylation". Biochim. Biophys. Acta. 1736 (2): 87–93. doi:10.1016/j.bbalip.2005.08.002. PMID 16137924.
- ^ Fernández-Murray JP, McMaster CR (March 2007). "Phosphatidylcholine synthesis and its catabolism by yeast neuropathy target esterase 1". Biochim. Biophys. Acta. 1771 (3): 331–6. doi:10.1016/j.bbalip.2006.04.004. PMID 16731034.
- ^ Li Y, Dinsdale D, Glynn P (March 2003). "Protein domains, catalytic activity, and subcellular distribution of neuropathy target esterase in Mammalian cells". J. Biol. Chem. 278 (10): 8820–5. doi:10.1074/jbc.M210743200. PMID 12514188.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Zaccheo O, Dinsdale D, Meacock PA, Glynn P (June 2004). "Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells". J. Biol. Chem. 279 (23): 24024–33. doi:10.1074/jbc.M400830200. PMID 15044461.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Glynn P, Holton JL, Nolan CC, Read DJ, Brown L, Hubbard A, Cavanagh JB (March 1998). "Neuropathy target esterase: immunolocalization to neuronal cell bodies and axons". Neuroscience. 83 (1): 295–302. doi:10.1016/S0306-4522(97)00388-6. PMID 9466418.
- ^ Moser M, Li Y, Vaupel K, Kretzschmar D, Kluge R, Glynn P, Buettner R (February 2004). "Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice". Mol. Cell. Biol. 24 (4): 1667–79. doi:10.1128/mcb.24.4.1667-1679.2004. PMC 344166. PMID 14749382.
- ^ Gallazzini M, Ferraris JD, Kunin M, Morris RG, Burg MB (October 2006). "Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl". Proc. Natl. Acad. Sci. U.S.A. 103 (41): 15260–5. doi:10.1073/pnas.0607133103. PMC 1622810. PMID 17015841.
- ^ Mühlig-Versen M, da Cruz AB, Tschäpe JA, Moser M, Büttner R, Athenstaedt K, Glynn P, Kretzschmar D (March 2005). "Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila". J. Neurosci. 25 (11): 2865–73. doi:10.1523/JNEUROSCI.5097-04.2005. PMC 1182176. PMID 15772346.
- ^ Read DJ, Li Y, Chao MV, Cavanagh JB, Glynn P (September 2009). "Neuropathy target esterase is required for adult vertebrate axon maintenance". J. Neurosci. 29 (37): 11594–600. doi:10.1523/JNEUROSCI.3007-09.2009. PMC 3849655. PMID 19759306.
- ^ Gallazzini, M.; Burg, M. B. (2009). "What's New About Osmotic Regulation of Glycerophosphocholine". Physiology. 24 (4): 245–249. doi:10.1152/physiol.00009.2009. PMC 2943332. PMID 19675355.
- ^ Rainier S, Bui M, Mark E, Thomas D, Tokarz D, Ming L, Delaney C, Richardson RJ, Albers JW, Matsunami N, Stevens J, Coon H, Leppert M, Fink JK (March 2008). "Neuropathy target esterase gene mutations cause motor neuron disease". Am. J. Hum. Genet. 82 (3): 780–5. doi:10.1016/j.ajhg.2007.12.018. PMC 2427280. PMID 18313024.
- ^ Rainier S, Albers JW, Dyck PJ, Eldevik OP, Wilcock S, Richardson RJ, Fink JK (January 2011). "Motor neuron disease due to neuropathy target esterase gene mutation: clinical features of the index families". Muscle Nerve. 43 (1): 19–25. doi:10.1002/mus.21777. hdl:2027.42/78477. PMID 21171093.
- ^ Lotti M, Moretto A (2005). "Organophosphate-induced delayed polyneuropathy". Toxicol Rev. 24 (1): 37–49. doi:10.2165/00139709-200524010-00003. PMID 16042503.
- ^ CAVANAGH JB (August 1954). "The toxic effects of triortho-cresyl phosphate on the nervous system; an experimental study in hens". J. Neurol. Neurosurg. Psychiatry. 17 (3): 163–72. doi:10.1136/jnnp.17.3.163. PMC 503178. PMID 13192490.
- ^ CASIDA JE, ETO M, BARON RL (September 1961). "Biological activity of a trio-cresyl phosphate metabolite". Nature. 191 (4796): 1396–7. doi:10.1038/1911396a0. PMID 13877086.
- ^ Johnson MK (October 1969). "The delayed neurotoxic effect of some organophosphorus compounds. Identification of the phosphorylation site as an esterase". Biochem. J. 114 (4): 711–7. doi:10.1042/bj1140711. PMC 1184957. PMID 4310054.
- ^ Glynn P, Read DJ, Guo R, Wylie S, Johnson MK (July 1994). "Synthesis and characterization of a biotinylated organophosphorus ester for detection and affinity purification of a brain serine esterase: neuropathy target esterase". Biochem. J. 301 ( Pt 2) (2): 551–6. doi:10.1042/bj3010551. PMC 1137116. PMID 8043002.
- ^ Read DJ, Li Y, Chao MV, Cavanagh JB, Glynn P (May 2010). "Organophosphates induce distal axonal damage, but not brain oedema, by inactivating neuropathy target esterase". Toxicol. Appl. Pharmacol. 245 (1): 108–15. doi:10.1016/j.taap.2010.02.010. PMID 20188121.
Further reading
- Glynn P (2000). "Neural development and neurodegeneration: two faces of neuropathy target esterase". Prog. Neurobiol. 61 (1): 61–74. doi:10.1016/S0301-0082(99)00043-X. PMID 10759065.
- Maroni M, Bleecker ML (1986). "Neuropathy target esterase in human lymphocytes and platelets". Journal of Applied Toxicology : JAT. 6 (1): 1–7. doi:10.1002/jat.2550060102. PMID 3958422.
- Bertoncin D, Russolo A, Caroldi S, Lotti M (1985). "Neuropathy target esterase in human lymphocytes". Arch. Environ. Health. 40 (3): 139–44. doi:10.1080/00039896.1985.10545905. PMID 4026382.
- Gurba PE, Richardson RJ (1983). "Partial characterization of neurotoxic esterase of human placenta" (PDF). Toxicol. Lett. 15 (1): 13–7. doi:10.1016/0378-4274(83)90162-5. hdl:2027.42/25337. PMID 6836585.
- van Tienhoven M, Atkins J, Li Y, Glynn P (2002). "Human neuropathy target esterase catalyzes hydrolysis of membrane lipids". J. Biol. Chem. 277 (23): 20942–8. doi:10.1074/jbc.M200330200. PMID 11927584.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Li Y, Dinsdale D, Glynn P (2003). "Protein domains, catalytic activity, and subcellular distribution of neuropathy target esterase in Mammalian cells". J. Biol. Chem. 278 (10): 8820–5. doi:10.1074/jbc.M210743200. PMID 12514188.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Winrow CJ; Hemming ML; Allen DM; et al. (2003). "Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity". Nat. Genet. 33 (4): 477–85. doi:10.1038/ng1131. PMID 12640454.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.