1-methyladenosine
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Surname | 1-methyladenosine | ||||||||||||
other names |
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Molecular formula | C 11 H 15 N 5 O 4 | ||||||||||||
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properties | |||||||||||||
Molar mass | 281.27 g mol −1 | ||||||||||||
Physical state |
firmly |
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safety instructions | |||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
1-methyladenosine (m 1 A) is a rare nucleoside and occurs in tRNA and rRNA . It consists of β- D- ribofuranose (sugar) and 1-methyladenine . It is a derivative of adenosine which is methylated in the 1-position .
properties
Base pairing is not possible due to the methylation in the 1-position . For example, it sits in the tRNA Phe in the TΨC arm.
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: "Summary: the modified nucleosides of RNA", Nucleic Acids Research , 1994 , 22 (12), pp. 2183-2196 ( doi : 10.1093 / nar / 22.12 .2183 , PMC 523672 (free full text), PMID 7518580 ).
- ↑ H. Shi, PB Moore : "The crystal structure of yeast phenylalanine tRNA at 1.93 Å resolution: a classic structure revisited", in: RNA , 2000 , 6 (8), pp. 1091–1105 ( PMC 1369984 (free full text) ; PMID 10943889 ).
Web links
- Entry for 1-methyladenosine in the Human Metabolome Database (HMDB) , accessed September 24, 2013.
- Modification Summary of 1-Methyladenosine in the Modomics database, accessed January 13, 2014.
- The RNA Modification Database: 1-methyladenosine , accessed September 21, 2014.