1-methyladenosine

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Structural formula
Structural formula of 1-methyladenosine
General
Surname 1-methyladenosine
other names
  • m 1 A (short code)
  • 9-β- D- ribofuranosyl-6-imino-1-methyl-purine
  • 9 - [(2 R , 3 R , 4 S , 5 R ) -3,4-dihydroxy-5- (hydroxymethyl) oxolan-2-yl] -6-imino-1-methyl-purine
Molecular formula C 11 H 15 N 5 O 4
External identifiers / databases
CAS number 15763-06-1
PubChem 27476
ChemSpider 17216227
Wikidata Q161643
properties
Molar mass 281.27 g mol −1
Physical state

firmly

safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

1-methyladenosine (m 1 A) is a rare nucleoside and occurs in tRNA and rRNA . It consists of β- D- ribofuranose (sugar) and 1-methyladenine . It is a derivative of adenosine which is methylated in the 1-position .

properties

Base pairing is not possible due to the methylation in the 1-position . For example, it sits in the tRNA Phe in the TΨC arm.

A tRNA Phe from S. cerevisiae .
1-methyl adenosine here with m 1 A marked.

Individual evidence

  1. This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: "Summary: the modified nucleosides of RNA", Nucleic Acids Research , 1994 , 22  (12), pp. 2183-2196 ( doi : 10.1093 / nar / 22.12 .2183 , PMC 523672 (free full text), PMID 7518580 ).
  3. H. Shi, PB Moore : "The crystal structure of yeast phenylalanine tRNA at 1.93 Å resolution: a classic structure revisited", in: RNA , 2000 , 6  (8), pp. 1091–1105 ( PMC 1369984 (free full text) ; PMID 10943889 ).

Web links

  • Entry for 1-methyladenosine in the Human Metabolome Database (HMDB) , accessed September 24, 2013.
  • Modification Summary of 1-Methyladenosine in the Modomics database, accessed January 13, 2014.
  • The RNA Modification Database: 1-methyladenosine , accessed September 21, 2014.