2,5-dimethoxy-4-trifluoromethylphenethylamine

Structural formula
General
Surname	2,5-dimethoxy-4-trifluoromethylphenethylamine
other names	2C-TFM; 2- [2,5-dimethoxy-4- (trifluoromethyl) phenyl] ethanamine ( IUPAC ); 2C-CF3;
Molecular formula	C 11 H 14 F 3 NO 2
Brief description	white crystals (hydrochloride)
External identifiers / databases
PubChem	10399795
ChemSpider	8575233
Wikidata	Q3014225
properties
Molar mass	249.23 g mol −1
Physical state	firmly
Melting point	260 ° C (hydrochloride)
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

2,5-Dimethoxy-4-trifluoromethylphenethylamine (abbreviated 2C-TFM ) is a psychedelic research chemical which, due to its structure, belongs to the groups of phenol ethers , phenethylamines and the 2C group of substances .

history

A working group led by the American pharmacist David E. Nichols synthesized 2C-TFM for the first time and described synthesis, receptor binding affinities and substance discrimination studies in rats in 1994 .

Pharmacodynamics

Very little is known about the effects of 2C-TFM in the human body. The mode of action of the 2C-TFM as a potent agonist of the 5-HT _2A / _2C receptors has been described.

Pharmacokinetics

The orally effective dose in humans is given by Trachsel as 3–5 mg, the duration of action is 5–7 hours.

literature

David E. Nichols, Stewart Frescas, Danuta Marona-Lewicka, Xuemei Huang, Bryan L. Roth, Gary A. Gudelsky, J. Frank Nash: 1- (2,5-dimethoxy-4- (trifluoromethyl) phenyl) -2- aminopropane: A Potent Serotonin 5-HT2A / 2C Agonist. In: Journal of Medicinal Chemistry. 37, 1994, pp. 4346-4351, doi : 10.1021 / jm00051a011
Daniel Trachsel: Fluorine in psychedelic phenethylamines. In: Drug Testing and Analysis. 4, 2012, pp. 577-590, doi : 10.1002 / dta.413 .
Alexander T. Shulgin, Tania Manning, Paul F. Daley: The Shulgin Index: Psychedelic Phenethylamines and Related Compounds Volume. Transform Press, Berkeley 2011, ISBN 0-9630096-3-X .

Web links

isomerdesign.com: 2C-TFM (English)

Individual evidence

↑ ^a ^b ^c ^d ^e David E. Nichols, Stewart Frescas, Danuta Marona-Lewicka, Xuemei Huang, Bryan L. Roth, Gary A. Gudelsky, J. Frank Nash: 1- (2,5-dimethoxy-4- (trifluoromethyl ) phenyl) -2-aminopropane: A Potent Serotonin 5-HT2A / 2C Agonist. In: Journal of Medicinal Chemistry. 37, 1994, pp. 4346-4351, doi : 10.1021 / jm00051a011 .
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ Daniel Trachsel: Fluorine in psychedelic phenethylamines. In: Drug Testing and Analysis . 4, 2012, pp. 577-590, doi : 10.1002 / dta.413 .

[DOI10.1021/jm00051a011-1] David E. Nichols, Stewart Frescas, Danuta Marona-Lewicka, Xuemei Huang, Bryan L. Roth, Gary A. Gudelsky, J. Frank Nash: 1- (2,5-dimethoxy-4- (trifluoromethyl ) phenyl) -2-aminopropane: A Potent Serotonin 5-HT2A / 2C Agonist. In: Journal of Medicinal Chemistry. 37, 1994, pp. 4346-4351, doi : 10.1021 / jm00051a011 .

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[DOI10.1002/dta.413-3] Daniel Trachsel: Fluorine in psychedelic phenethylamines. In: Drug Testing and Analysis . 4, 2012, pp. 577-590, doi : 10.1002 / dta.413 .