4-chloromercuric benzoic acid

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Structural formula
Structure of 4-chloromercuribenzoic acid
General
Surname 4-chloromercuric benzoic acid
other names
  • p -chloromercuribenzoic acid
  • para -chloromercuribenzoic acid
  • PCMB
Molecular formula C 7 H 5 ClHgO 2
External identifiers / databases
CAS number 59-85-8
EC number 200-442-6
ECHA InfoCard 100,000,402
PubChem 1730
Wikidata Q229946
properties
Molar mass 357.16 g mol −1
Physical state

firmly

Melting point

287 ° C

safety instructions
GHS hazard labeling from  Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary
06 - Toxic or very toxic 08 - Dangerous to health 09 - Dangerous for the environment

danger

H and P phrases H: 300-310-330-373-410
P: 260-264-273-280-284-301 + 310
Toxicological data

25 mg kg −1 ( LD 50 ,  mouse ,  ip )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

4-chloromercuric benzoic acid is an organic mercury compound that is used as a protease inhibitor , primarily in biochemistry .

Biochemical properties

PCMB reacts with SH groups ( thiol groups ) in proteins and is thus an inhibitor for enzymes that are dependent on SH reactivity. It inhibits the cysteine ​​protease papain , but also the acetylcholinesterase of mammals.

use

Due to its SH reactivity, it is used in special titrations to quantify thiol groups in proteins.

swell

  1. ↑ a b c d data sheet 4-Chloromercuribenzoic acid from Sigma-Aldrich , accessed on March 18, 2011 ( PDF ).
  2. ↑ Not explicitly listed in Regulation (EC) No. 1272/2008 (CLP) , but with the specified labeling it falls under the group entry organic compounds of mercury with the exception of those specified elsewhere in this Annex in the Classification and Labeling Inventory of the European Chemicals Agency ( ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

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