Ribothymidine

from Wikipedia, the free encyclopedia
Structural formula
Structural formula of ribothymidine
General
Surname Ribothymidine
other names
  • T (short code), m 5 U (short code)
  • 5-methyluridine
  • 1-β- D- ribofuranosyl-5-methylpyrimidine-2,4-dione
  • 1 - [(2 R , 3 R , 4 S , 5 R ) -3,4-dihydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-methylpyrimidin-2,4-dione
  • Thymine riboside
Molecular formula C 10 H 14 N 2 O 6
External identifiers / databases
CAS number 1463-10-1
EC number 215-973-9
ECHA InfoCard 100.014.522
PubChem 445408
Wikidata Q425078
properties
Molar mass 258.23 g mol −1
Physical state

firmly

Melting point

183-184 ° C

safety instructions
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Ribothymidine (often also 5-methyluridine ) is a rare nucleoside and occurs in tRNA and rRNA . It consists of β- D- ribofuranose (sugar) and the nucleobase thymine . The analogue with deoxyribose that occurs as standard in DNA is deoxythymidine , which is often referred to simply as thymidine .

Ribothymidine sits in the TΨC loop of tRNA.

A tRNA Ala from S. cerevisiae .
Ribothymidine is marked with a T here .

Individual evidence

  1. a b c data sheet 5-methyluridine from Sigma-Aldrich , accessed on March 11, 2011 ( PDF ).
  2. Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: "Summary: the modified nucleosides of RNA", Nucleic Acids Research , 1994 , 22  (12), pp. 2183-2196 ( doi : 10.1093 / nar / 22.12 .2183 , PMC 523672 (free full text), PMID 7518580 ).
  3. ^ Robert W. Holley , Jean Apgar, George A. Everett, James T. Madison, Mark Marquisee, Susan H. Merrill, John Robert Penswick, Ada Zamir: "Structure of a Ribonucleic Acid", Science , 1965 , 147 , pp. 1462-1465 ( doi : 10.1126 / science.147.3664.1462 ).

Web links

  • Entry for ribothymidines in the Human Metabolome Database (HMDB) , accessed September 24, 2013.
  • Modification Summary of 5-methyluridine in the Modomics database, accessed January 14, 2014.