ADGRE5

from Wikipedia, the free encyclopedia
CD97 antigen
CD97 antigen
according to 2BO2
other names

Leukocyte antigen CD97, ADGRE5, TM7LN1, CD97, adhesion G protein-coupled receptor E5, BL-Ac [F2]

Properties of human protein
Mass / length primary structure 835 amino acids , 91,869 Da
Identifier
External IDs
Orthologue (human)
Entrez 976
Ensemble ENSG00000123146
UniProt P48960
Refseq (mRNA) NM_001025160.2
Refseq (protein) NP_001020331.1
PubMed search 976

ADGRE5 (synonymous CD97 ) is a surface protein from the group of G protein-coupled receptors .

properties

ADGRE5 is made up of many cell types, including most of the hematopoietic cells and smooth muscle cells . In addition, it is of different tumors generated as that of the thymus , of the colon , of the stomach , the esophagus the mouth and of the pancreas . The formation is increased in multiple sclerosis , inflammation and arthritis in the connective tissue . ADGRE5 is a heptahelical receptor from the subgroup of Adhesion-GPCR . Adhesion GPCRs have a large extracellular domain that is linked to the seven transmembrane domains via a GAIN protein domain . ADGRE5 is glycosylated and phosphorylated . There are several EGF -like protein domains at the N terminus . By alternative splicing of three variants are generated. Two fragments of ADGRE5 are formed by proteolysis . It is believed to be involved in the formation of cell contacts and cell migration of leukocytes . ADGRE5 binds to chondroitin sulfate and to CD55 .

ADGRE5 is involved in the invasion of tumors, and increased formation is a negative prognostic factor. The different isoforms have different functions for tumors. The small EGF (1,2,5) isoform promotes metastasis of gastric cancer while the largest isoform EGF (1-5) inhibits metastasis.

Web links

Individual evidence

  1. ↑ van Pel M, Hagoort H, Hamann J, Fibbe WE: CD97 is differentially expressed on murine hematopoietic stem and progenitor cells . In: Haematologica . 93, No. 8, August 2008, pp. 1137-44. doi : 10.3324 / haematol.12838 . PMID 18603564 .
  2. ↑ Eichler W, Hamann J, Aust G: Expression characteristics of the human CD97 antigen . In: Tissue Antigens . 50, No. 5, November 1997, pp. 429-38. doi : 10.1111 / j.1399-0039.1997.tb02897.x . PMID 9389316 .
  3. ↑ Jaspars LH, Vos W, Aust G, Van Lier RA, Hamann J: Tissue distribution of the human CD97 EGF-TM7 receptor . In: Tissue Antigens . 57, No. 4, April 2001, pp. 325-31. doi : 10.1034 / j.1399-0039.2001.057004325.x . PMID 11380941 .
  4. ^ Aust G, Wandel E, Boltze C, Sittig D, Schütz A, Horn LC, Wobus M: Diversity of CD97 in smooth muscle cells . In: Cell and Tissue Research . 324, No. 1, April 2006, pp. 139-47. doi : 10.1007 / s00441-005-0103-2 . PMID 16408199 .
  5. ↑ Veninga H, Becker S, Hoek RM, Wobus M, Wandel E, van der Kaa J, van der Valk M, de Vos AF, Haase H, Owens B, van der Poll T, van Lier RA, Verbeek JS, Aust G , Hamann J: Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration . In: Journal of Immunology . 181, No. 9, November 2008, pp. 6574-83. doi : 10.4049 / jimmunol.181.9.6574 . PMID 18941248 .
  6. ↑ Zyryanova T, Schneider R, Adams V, Sittig D, Kerner C, Gebhardt C, Ruffert H, Glasmacher S, Hepp P, Punkt K, Neuhaus J, Hamann J, Aust G: Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function . In: PLOS ONE . 9, No. 6, 2014, p. E100513. doi : 10.1371 / journal.pone.0100513 . PMID 24949957 . PMC 4065095 (free full text).
  7. ↑ Stacey M, Yona S: Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer, Berlin 2011, ISBN 1-4419-7912-3 .
  8. ^ T Langenhan, G Aust, J Hamann: Sticky signaling - adhesion class G protein-coupled receptors take the stage. . In: Science signaling . 6, No. 276, May 21, 2013, p. Re3. doi : 10.1126 / scisignal.2003825 . PMID 23695165 .
  9. ↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT: A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis . In: The EMBO Journal . 31, No. 6, March 2012, pp. 1364-78. doi : 10.1038 / emboj.2012.26 . PMID 22333914 . PMC 3321182 (free full text).
  10. ^ Gordon S, Hamann J, Lin HH, Stacey M: F4 / 80 and the related adhesion GPCRs . In: European Journal of Immunology . 41, No. 9, September 2011, pp. 2472-6. doi : 10.1002 / eji.201141715 . PMID 21952799 .
  11. ^ Wobus M, Huber O, Hamann J, Aust G: CD97 overexpression in tumor cells at the invasion front in colorectal cancer (CC) is independently regulated of the canonical Wnt pathway . In: Molecular Carcinogenesis . 45, No. 11, November 2006, pp. 881-6. doi : 10.1002 / mc.20262 . PMID 16929497 .
  12. ↑ Safaee M, Clark AJ, Oh MC, Ivan ME, Bloch O, Kaur G, Sun MZ, Kim JM, Oh T, Berger MS, Parsa AT: Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients . In: PLOS ONE . 8, No. 4, 2013, p. E62765. doi : 10.1371 / journal.pone.0062765 . PMID 23658650 . PMC 3637305 (free full text).
  13. ^ Wobus M, Huber O, Hamann J, Aust G: CD97 overexpression in tumor cells at the invasion front in colorectal cancer (CC) is independently regulated of the canonical Wnt pathway . In: Molecular Carcinogenesis . 45, No. 11, November 2006, pp. 881-6. doi : 10.1002 / mc.20262 . PMID 16929497 .
  14. ↑ Liu JK, Lubelski D, Schonberg DL, Wu Q, Hale JS, Flavahan WA, Mulkearns-Hubert EE, Man J, Hjelmeland AB, Yu J, Lathia JD, Rich JN: Phage display discovery of novel molecular targets in glioblastoma-initiating cells . In: Cell Death and Differentiation . 21, No. 8, August 2014, pp. 1325-39. doi : 10.1038 / cdd.2014.65 . PMID 24832468 . PMC 4085538 (free full text).
  15. ↑ Steinert M, Wobus M, Boltze C, Schütz A, Wahlbuhl M, Hamann J, Aust G: Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues . In: The American Journal of Pathology . 161, No. 5, November 2002, pp. 1657-67. doi : 10.1016 / S0002-9440 (10) 64443-4 . PMID 12414513 . PMC 1850798 (free full text).
  16. ↑ Mustafa T, Eckert A, Klonisch T, Kehlen A, Maurer P, Klintschar M, Erhuma M, Zschoyan R, Gimm O, Dralle H, Schubert J, Hoang-Vu C: Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas . In: Cancer Epidemiology, Biomarkers & Prevention . 14, No. 1, January 2005, pp. 108-19. PMID 15668483 .
  17. ↑ Wu J, Lei L, Wang S, Gu D, Zhang J: Immunohistochemical expression and prognostic value of CD97 and its ligand CD55 in primary gallbladder carcinoma . In: Journal of Biomedicine & Biotechnology . 2012, 2012, p. 587672. doi : 10.1155 / 2012/587672 . PMID 22547928 . PMC 3324160 (free full text).
  18. ↑ He Z, Wu H, Jiao Y, Zheng J: Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer . In: Oncology Letters . 9, No. 2, February 2015, pp. 793-797. doi : 10.3892 / ol.2014.2751 . PMID 25624904 . PMC 4301556 (free full text).
  19. ↑ Liu D, Trojanowicz B, Ye L, Li C, Zhang L, Li X, Li G, Zheng Y, Chen L: The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma . In: PLOS ONE . 7, No. 6, 2012, p. E39989. doi : 10.1371 / journal.pone.0039989 . PMID 22768192 . PMC 3386904 (free full text).
  20. ↑ Liu D, Trojanowicz B, Radestock Y, Fu T, Hammje K, Chen L, Hoang-Vu C: Role of CD97 isoforms in gastric carcinoma . In: International Journal of Oncology . 36, No. 6, June 2010, pp. 1401-8. PMID 20428763 .