Adenine phosphoribosyl transferase
| Adenine phosphoribosyl transferase | ||
|---|---|---|
|
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| Ribbon model of the APRT of humans in complex with the substrates, according to PDB 1ZN7 | ||
| Properties of human protein | ||
| Identifier | ||
| Gene name | APRT | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.4.2.7 , transferase | |
| Response type | Transfer of a phosphoribosyl residue | |
| Substrate | Adenine + PRPP | |
| Products | AMP + phosphate | |
| Occurrence | ||
| Parent taxon | Creature | |
The adenine phosphoribosyltransferase is the enzyme that the synthesis of AMP from adenine and PRPP catalyzed . This salvage pathway reaction is much more efficient than the de novo biosynthesis of AMP. The enzyme occurs in all living things and in humans in all tissue types. Mutations in APRT - gene may be responsible for APRT deficiency leading to an inherited form of kidney stones leads.
Catalyzed reaction
+ + PP i
Ribose phosphate is transferred to adenine, AMP is formed.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Purine Metabolism - Learning and Teaching Materials
- reactome: adenine + PRPP → AMP + PPi