Phosphoribosyl pyrophosphate

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Structural formula
Structure of phosphoribosyl pyrophosphate
General
Surname Phosphoribosyl pyrophosphate
other names
  • PRPP
  • 5-phosphoribosyl diphosphate
Molecular formula [C 5 H 8 O 14 P 3 ] 5-
External identifiers / databases
CAS number 13270-65-0
PubChem 7339
DrugBank DB01632
Wikidata Q420633
properties
Molar mass 390.07 g mol −1
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

α-5'-phosphoribosyl-1'-pyrophosphate (PRPP) is a chemical compound . It is a ribose (a sugar) which is substituted on carbon atom 5 (C5) with a phosphate group and on C1 with a pyrophosphate group . Phosphoribosyl pyrophosphate occurs primarily as an intermediate in metabolism , for example in the biosynthesis of purine and pyrimidine nucleotides .

It is also required as a cosubstrate in the biosynthesis of NAD + / NADP + from nicotinic acid .

Phosphoribosyl pyrophosphate reacts with nicotinate, the anion of nicotinic acid, to form nicotinate mononucleotide with cleavage of pyrophosphate (PP i ).

PRPP is synthesized in the body from ribose-5-phosphate and ATP or deoxy-ATP. The reaction is catalyzed by the enzyme ribose phosphate pyrophosphokinase .

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ d'Eustachio / reactome: 5-phosphoribose 1-diphosphate biosynthesis

Web links

Wikibooks: Biochemistry and pathobiochemistry: alpha-D-5-phosphoribosyl-1-pyrophosphate  - learning and teaching materials