Albrecht E. Sippel

from Wikipedia, the free encyclopedia

Albrecht Erhard Sippel (born July 11, 1942 in Rastenburg ) is a German geneticist and emeritus professor of the Faculty of Biology at the Albert Ludwig University of Freiburg .

career

Albrecht E. Sippel studied biology at the University of Würzburg, where he wrote his diploma thesis in 1967 with Guido Hartmann. In the following three years he completed his diploma and doctoral theses. Sippel was Würzburg's first graduate biologist. He then accepted the offer for a postdoc position with Nobel Prize winner James Watson at Harvard University . Several years followed at the Medical School of Columbia University in New York.

In 1975 Sippel returned to Germany to work at the Max Planck Institute for Molecular Genetics in Berlin. There he examined the structure and regulation of the genes of the protein proteins (egg whites) of the chicken egg. With his colleagues, including Günther Schütz , he gained important knowledge about the hormonal regulation of the genes for ovalbumin , ovomucoid and lysozyme , the mRNA expression of which is regulated by steroids , especially estrogens .

In 1979 he took over the leadership of an independent research group at the Institute for Genetics at the University of Cologne . In 1983 he helped found the Center for Molecular Biology at Heidelberg University (ZMBH). Thanks to his work, the lysozyme gene became one of the best-studied eukaryotic genes. So Sippel and his colleague Joachim Nowock discovered the first transcription factor , the TGGCA protein ( Nuclear factor I, CCAAT binding transcription factor ) in eukaryotes for the lysozyme gene. In Heidelberg, he expanded the studies to include mice and, in particular, the regulation of the lysozyme gene in macrophages .

In 1990 he took over the chair for genetics at the Albert Ludwig University of Freiburg . Here he researched the elementary molecular mechanisms of the development of blood cells. Between 1995 and 1997 he was Dean of the Faculty of Biology. In 1992 he was elected a Fellow of the American Association for the Advancement of Science .

Since 2007 Albrecht E. Sippel has been professor emeritus for genetics at the University of Freiburg. After his retirement he went to the Max Planck Institute for Evolutionary Anthropology in Leipzig as a visiting scientist in the group of Svante Pääbo .

Important publications

  • NE Hynes, B. Groner, AE Sippel, MC Nguyen-Huu, G. Schütz: mRNA complexity and egg white protein mRNA content in mature and hormone-withdrawn oviduct . In: Cell . tape 11 , no. 4 , 1977, pp. 923-932 , doi : 10.1016 / 0092-8674 (77) 90303-8 .
  • PJ Artymiuk, CC Blake, AE Sippel: Genes pieced together - exons delineate homologous structures of diverged lysozymes . In: Nature . tape 290 , no. 5804 , 1981, pp. 287-288 , doi : 10.1038 / 290287a0 , PMID 7207621 .
  • M. Grez, H. Land, K. Giesecke, G. Schütz, A. Jung, AE Sippel: Multiple mRNAs are generated from the chicken lysozyme gene . In: Cell . tape 25 , no. 3 , 1981, p. 743-752 , doi : 10.1016 / 0092-8674 (81) 90182-3 .
  • J. Nowock, AE Sippel: Specific protein-DNA interaction at four sites flanking the chicken lysozyme gene . In: Cell . tape 30 , no. 2 , 1982, p. 607-615 , doi : 10.1016 / 0092-8674 (82) 90257-4 .
  • HP Fritton, T. Igo-Kemenes, J. Nowock, U. Strech-Jurk, M. Theisen, AE Sippel: Alternative sets of DNase I-hypersensitive sites characterize the various functional states of the chicken lysozyme gene . In: Nature . tape 311 , no. 5982 , 1984, pp. 163-165 , doi : 10.1038 / 311163a0 .
  • H. Biedenkapp, U. Borgmeyer, AE Sippel, KH Klempnauer: Viral myb oncogene encodes a sequence-specific DNA-binding activity . In: Nature . tape 335 , no. 6193 , October 27, 1988, p. 835-837 , doi : 10.1038 / 335835a0 .
  • A. Stief, DM Winter, WH Strätling, AE Sippel: A nuclear DNA attachment element mediates elevated and position-independent gene activity . In: Nature . tape 341 , no. 6240 , September 28, 1989, pp. 343-345 , doi : 10.1038 / 341343a0 .

Sources and web links

Individual proof

  1. ↑ Albrecht Sippel - A geneticist with a penchant for philosophy .
personal data
SURNAME Sippel, Albrecht Erhard
ALTERNATIVE NAMES Sippel, Albrecht E.
BRIEF DESCRIPTION German geneticist and university professor
DATE OF BIRTH July 11, 1942
PLACE OF BIRTH Rastenburg