Aminorex

Structural formula
	Structural formula without stereochemistry
General
Non-proprietary name	Aminorex
other names	Aminoxaphene; ( RS ) -2-amino-4,5-dihydro-5-phenyl-2-oxazole ( IUPAC ); ( RS ) -2-amino-5-phenyl-2-oxazoline; ( RS ) -5-phenyl-4,5-dihydro-1,3-oxazol-2-ylazane;
Molecular formula	C 9 H 10 N 2 O
External identifiers / databases
EC number	636-641-3
ECHA InfoCard	100.164.420
PubChem	16630
DrugBank	DB01490
Wikidata	Q4064330
Drug information
Drug class	Anorectics
properties
Molar mass	162.19 g / mol
Physical state	firmly
Melting point	137 ° C
safety instructions
GHS labeling of hazardous substances danger
H and P phrases	H: 300-310-330
	P: 260-264-280-284-302 + 350-310
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Aminorex is a synthetically produced chemical compound that was marketed under the name Menocil as an appetite suppressant ( anorectic ) in Switzerland in 1965 and in Germany and Austria in 1966. Menocil was withdrawn from the market as early as 1968 after the occurrence of precapillary pulmonary hypertension had been observed, some of which resulted in death.

Aminorex is structurally closely related to 4-methylaminorex . In Germany, Aminorex is a marketable, but not a prescription drug .

Mode of action

Aminorex releases endogenous catecholamine stores and inhibits serotonin recovery .

Individual evidence

↑ ^a ^b ^c Datasheet Aminorex, solid at Sigma-Aldrich , accessed on February 18, 2013 ( PDF ).
↑ David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-178.
^ As in Zuckerl , Spiegel, issue 52 of December 23, 1968.
↑ ^a ^b Hans-Joachim Schäfers u. a .: Pulmonary hypertension . Blackwell Wiss.-Verl., 2001, ISBN 3894124830 .
↑ Information refused , Spiegel, issue 49 of November 30, 1970.
↑ Appendix II (to Section 1, Paragraph 1) marketable but not prescription drugs .

[Sigma-1] Datasheet Aminorex, solid at Sigma-Aldrich , accessed on February 18, 2013 ( PDF ).

[CRC90_3_178-2] David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-178.

[3] As in Zuckerl , Spiegel, issue 52 of December 23, 1968.

[Schäfers-4] Hans-Joachim Schäfers u. a .: Pulmonary hypertension . Blackwell Wiss.-Verl., 2001, ISBN 3894124830 .

[5] Information refused , Spiegel, issue 49 of November 30, 1970.

[6] Appendix II (to Section 1, Paragraph 1) marketable but not prescription drugs .