Bactridine

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Tityus discrepans
Bactridine-1
other names

P-Arthr-Antm-beta * NaTx2.6

Mass / length primary structure 61 amino acids , 6,928 Da
Identifier
External IDs

Bactridine-2
other names

P-Mice-Antm-beta * NaTx14.8

Mass / length primary structure 64 amino acids , 7,374 Da
Identifier
External IDs

Bactridines are a group of toxins in the venom of the thick-tailed scorpion Tityus discrepans .

properties

Bactridines comprise six peptides . They bind to voltage-gated sodium channels , unusually those of both bacteria and eukaryotes . An antibacterial effect is achieved in bacteria, while the bactridines in eukaryotes serve to poison the prey and to ward off predators. In humans, bactridines produce edema in the lungs .

Bactridine are one of the longer scorpion toxins with four disulfide bridges . They (Bactridine 1-6) have the molecular weights 6916, 7362, 7226, 7011, 7101 and 7173 Da . There is an antitoxin , which consists of polyclonal antibodies against the Bactridine.

Individual evidence

  1. ^ A b P. Díaz, G. D'Suze, V. Salazar, C. Sevcik, JD Shannon, NE Sherman, JW Fox: Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na + permeability changes. In: Toxicon: official journal of the International Society on Toxinology. Volume 54, Number 6, November 2009, pp. 802-817, doi : 10.1016 / j.toxicon.2009.06.014 , PMID 19540868 .
  2. ↑ P. Forsyth, C. Sevcik, R. Martínez, C. Castillo, G. D'Suze: Bactridine's effects on DUM cricket neurons under voltage clamp conditions. In: Journal of insect physiology. Volume 58, Number 12, December 2012, pp. 1676–1685, doi : 10.1016 / j.jinsphys.2012.10.009 , PMID 23085555 .
  3. Jump up ↑ J. Brazón, CE Hughes, J. Mori, C. Sevcik, G. D'suze, SP Watson: Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway. In: Platelets. Volume 22, number 3, 2011, pp. 165-172, doi : 10.3109 / 09537104.2010.544343 , PMID 21322750 .
  4. ↑ Steve Peigneur, Carlos Sevcik u. a .: Subtype specificity interaction of bactridines with mammalian, insect and bacterial sodium channels under voltage clamp conditions. In: FEBS Journal. 279, 2012, pp. 4025-4038, doi : 10.1111 / j.1742-4658.2012.08808.x .
  5. ^ A. Borges, RG Tsushima, PH Backx: Antibodies against Tityus discrepans venom do not abolish the effect of Tityus serrulatus venom on the rat sodium and potassium channels. In: Toxicon: official journal of the International Society on Toxinology. Volume 37, Number 6, June 1999, pp. 867-881, doi : 10.1016 / S0041-0101 (98) 00201-3 , PMID 10340827 .
  6. ↑ P. Díaz, G. D'Suze, C. Sevcik: Ability of horse anti-Tityus discrepans F (ab ') 2 ELISA assay to recognize Tityus discrepans venom toxins. In: Toxicon: official journal of the International Society on Toxinology. Volume 88, September 2014, pp. 88-92, doi : 10.1016 / j.toxicon.2014.06.003 , PMID 24932739 .